Risk Factors for Urgency Incontinence in Women Undergoing Stress Urinary Incontinence Surgery
Table 1
Descriptive statistics by UUI status and results of separate bivariate logistic regression models with outcome of those having UUI. Results reported separately for the SISTEr and TOMUS trials.
Covariate
SISTEr ()
TOMUS ()
Yes ()
No ()
value
OR (95% CI)
Yes ()
No ()
value
OR (95% CI)
Menopausal status/hormone replacement therapy
0.002
0.01
No HRT, Postmenopausal
178 (39%)
53 (27%)
1
169 (42%)
74 (39%)
1
Yes HRT, Postmenopausal
156 (34%)
67 (34%)
0.69 (0.46–1.05)
126 (31%)
44 (23%)
1.25 (0.81–1.94)
Premenopausal
120 (26%)
76 (39%)
0.47 (0.31–0.72)
106 (26%)
72 (38%)
0.64 (0.43–0.97)
Prior to UI surgery and/or treatment
0.01
0.19
No
206 (45%)
110 (56%)
165 (41%)
89 (47%)
Yes
249 (55%)
86 (44%)
1.55 (1.10–2.17)
236 (59%)
101 (53%)
1.26 (0.89–1.78)
Prior to hysterectomy
0.09
0.03
No
306 (67%)
145 (74%)
276 (69%)
147 (77%)
Yes
149 (33%)
51 (26%)
1.38 (0.95–2.01)
125 (31%)
43 (23%)
1.55 (1.04–2.31)
Race/ethnicity
0.16
0.06
Hispanic
56 (12%)
15 (8%)
1.79 (0.98–3.27)
53 (13%)
17 (9%)
1.66 (0.93–2.95)
Non-Hispanic white
323 (71%)
155 (79%)
1
307 (76%)
163 (86%)
1
Non-Hispanic black
34 (7%)
10 (5%)
1.63 (0.79–3.39)
14 (3%)
3 (2%)
2.48 (0.70–8.75)
Non-Hispanic other
41 (9%)
16 (8%)
1.23 (0.67–2.26)
29 (7%)
7 (4%)
2.20 (0.94–5.13)
Parity
0.68
0.48
No pregnancies
16 (5%)
6 (4%)
1
17 (6%)
8 (5%)
1
One pregnancy
25 (7%)
14 (10%)
0.67 (0.21–2.10)
37 (12%)
27 (18%)
0.64 (0.24–1.71)
Two pregnancies
112 (33%)
49 (36%)
0.86 (0.32–2.32)
111 (37%)
51 (34%)
1.02 (0.42–2.53)
Three or more pregnancies
185 (55%)
69 (50%)
1.01 (0.38–2.67)
133 (45%)
65 (43%)
0.96 (0.39–2.35)
Education
0.002
<.0001
48 (11%)
6 (3%)
1
25 (6%)
8 (4%)
1
High school/GED
115 (25%)
56 (29%)
0.26 (0.10–0.64)
109 (27%)
39 (21%)
0.89 (0.37–2.15)
188 (41%)
70 (36%)
0.34 (0.14–0.82)
160 (40%)
57 (30%)
0.90 (0.38–2.11)
BA/BS
56 (12%)
42 (21%)
0.17 (0.07–0.43)
49 (12%)
52 (27%)
0.30 (0.12–0.73)
Grad/Prof
48 (11%)
22 (11%)
0.27 (0.10–0.73)
60 (15%)
34 (18%)
0.56 (0.23–1.39)
Prolapse stage
1
0.34
Stage 0 or 1
110 (24%)
48 (24%)
1
189 (47%)
77 (41%)
1
Stage 2
271 (60%)
116 (59%)
1.02 (0.68–1.53)
183 (45%)
96 (51%)
0.78 (0.54–1.12)
Stage 3+
74 (16%)
32 (16%)
1.01 (0.59–1.72)
31 (8%)
17 (9%)
0.74 (0.39–1.42)
UI Severity (PGI-S)*
N/A
0.001
Normal
38 (9%)
23 (12%)
1
Mild
30 (7%)
30 (16%)
0.61 (0.29–1.25)
Moderate
202 (50%)
97 (51%)
1.26 (0.71–2.23)
Severe
132 (33%)
39 (21%)
2.05 (1.09–3.84)
Depression (PHQ-9)*
N/A
0.0001
<10
293 (74%)
165 (88%)
1
10+ (defined as depression)
103 (26%)
22 (12%)
2.64 (1.60–4.34)
Charlson Comorbidity Index (CCI)*
N/A
0.03
0
287 (71%)
153 (81%)
1
1
69 (17%)
27 (14%)
1.36 (0.84–2.22)
2+
47 (12%)
10 (5%)
2.51 (1.23–5.10)
Mean (SD)
Mean (SD)
Mean (SD)
Mean (SD)
UDI stress score (UDI-S)
79.8 (20.2)
73.8 (25.0)
0.002
1.13 (1.05–1.22)
75.4 (20.6)
72.5 (23.1)
0.13
1.06 (0.98–1.15)
MESA stress score
20.2 (4.1)
17.2 (5.0)
<0.0001
1.15 (1.11–1.20)
20.0 (4.2)
17.9 (5.0)
<.0001
1.11 (1.06–1.15)
Age (years)
52.2 (10.1)
51.4 (10.8)
0.37
1.08 (0.92–1.27)
53.6 (10.9)
51.3 (10.9)
0.02
1.21 (1.03–1.43)
Body mass index
30.4 (6.3)
28.9 (5.4)
0.003
1.05 (1.02–1.08)
30.7 (7.0)
29.5 (6.2)
0.03
1.03 (1.00–1.06)
IIQ total
190.7 (100.7)
126.3 (87.7)
<0.0001
1.07 (1.05–1.09)
169.4 (98.2)
113.4 (83.4)
<.0001
1.07 (1.05–1.09)
Pad weight (g)
48.6 (87.6)
31.3 (54.1)
0.01
1.04 (1.01–1.08)
38.1 (66.9)
31.5 (66.6)
0.27
1.02 (0.99–1.05)
UI severity, depression, and number of comorbidities were not collected in the SISTEr trial.
