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Advances in Urology
Volume 2013 (2013), Article ID 752382, 6 pages
Clinical Study

Randomized Controlled Trial to Compare the Safety and Efficacy of Tamsulosin, Solifenacin, and Combination of Both in Treatment of Double-J Stent-Related Lower Urinary Symptoms

1Department of Urology, Suez Canal University, P.O. Box 224, Ismailia 41522, Egypt
2Department of Urology, King Khalid Hospital, P.O. Box 1985, Al-Kharj 11942, Saudi Arabia
3Department of Urology, Al-Azhar University, Nasr City, Cairo 11884, Egypt
4Department of Urology, Salman Bin Abdul-Aziz University, P.O. Box 173, Al-Kharj 11942, Saudi Arabia
5Department of Urology, Faculty of Medicine, Zagazig University, P.O. Box 203, Zagazig 44519, Egypt
6Department of Urology, King Abdallah Hospital, P.O. Box 60, Bisha 61922, Saudi Arabia
7Department of Urology, Insurance Hospital, Ismailia 41528, Egypt

Received 2 June 2013; Accepted 7 September 2013

Academic Editor: James A. Brown

Copyright © 2013 Essam Shalaby et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. We evaluated the effectiveness and safety of tamsulosin, solifenacin, and combination of both in reducing double-J stent-related lower urinary symptoms. Materials and Methods. A total of 338 patients with double-J ureteral stenting were randomly divided, postoperatively, into 4 groups. In group I ( ), no treatment was given (control group), group II ( ) received tamsulosin 0.4 mg daily, group III ( ) received solifenacin 10 mg daily, and group IV ( ) received a combination of both medications. Before insertion and 2 weeks after, all patients completed the International Prostate Symptom Score (IPSS), quality of life component of the IPSS (IPSS/Qol), Overactive Bladder Questionnaire (OAB-q), and Visual Analogue Pain Scale (VAPS) questionnaire. Results. The demographics and preoperative questionnaires scores of all groups were comparable. There were statistically significant differences in all scores in favour of groups II, III, and IV as compared to control group ( value < 0.005). Group IV showed statistically significant differences in total IPSS, QoL score, and OAB-q score as compared to groups II and III ( value < 0.001). Conclusions. Combined therapy of tamsulosin and solifenacin significantly alleviated lower urinary symptoms associated with double-J stents as compared to either medication alone.