Clinical Study
US Pilot Study of Lumbar to Sacral Nerve Rerouting to Restore Voiding and Bowel Function in Spina Bifida: 3-Year Experience
Table 1
Summary of changes over time.
| |
Baseline |
One year |
Two years |
Three years | | (%) | | (%) | | (%) |
| | NDO | 13 | 8 (61.5) | 13 | 2 (15.4) | 13 | 5 (38.5) | 10 | 2 (20) | | Able to void | 13 | 4 (30.8) | 13 | 9 (69.2) | 13 | 10 (76.9) | 10 | 8 (80) | | On CIC | 13 | 13 (100) | 13 | 10 (76.9) | 13 | 10 (76.9) | 10 | 2 (20) | | UI | 13 | 13 (100) | 13 | 13 (100) | 13 | 12 (92.3) | 10 | 9 (90) | | Cutaneous bladder reflex present | 4 | 0 | 13 | 8 (61.5) | 13 | 6 (46.2) | 9 | 2 (22.2) | | Consider bowels normal | 13 | 4 (30.8) | 13 | 3 (23.1) | 13 | 5 (38.5) | 10 | 7 (70) | |
*Improved urinary function | | | 13 | 7 (53.9) | 13 | 9 (69.2) | 10 | 5 (50) | | Continent of stool | 13 | 2 (15.4) | 13 | 4 (30.8) | 13 | 6 (46.2) | 10 | 5 (50) | |
*Improved bowel function | | | 13 | 8 (61.5) | 13 | 7 (53.9) | 10 | 5 (50) |
| | | | Mean ± SD (median) | | Mean ± SD (median) | | Mean ± SD (median) | | Mean ± SD (median) |
| | MCC | 13 | 213.46 ± 84.68 (200) | 13 | 250.77 ± 91.29 (230) | 13 | 249.38 ± 60.87 (246) | 10 | 291.1 ± 94.04 (284) | | Voided volume | 13 | 22.62 ± 54.91 (0) | 13 | 118.92 ± 125.24 (70) | 13 | 137.31 ± 130.49 (100) | 10 | 211.9 ± 133.58 (242.5) | | PVR | 4 | 231.75 ± 154.56 (208.5) | 12 | 126.25 ± 120.94 (100) | 13 | 122.31 ± 108.10 (125) | 10 | 131.40 ± 97.05 (132.50) |
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NDO: neurogenic detrusor overactivity; CIC: clean intermittent catheterization >1x/day; UI: urinary incontinence; MCC: maximum cystometric capacity; PVR: post-void residual.
*Slightly, moderately, or markedly improved response on Global Response Assessments (GRA).
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