Clinical Study
US Pilot Study of Lumbar to Sacral Nerve Rerouting to Restore Voiding and Bowel Function in Spina Bifida: 3-Year Experience
Table 3
Individual patient data.
| | Pt. number |
Age
(Yrs) | On CIC |
Using antimuscarinics
| NDO | Voided volume† |
Voiding efficiency
(%) | MCC (cc) |
Consider bowels
normal |
Continent of
stool | Change in bowel function (GRA) | Treatment responder | | Baseline | 3 Yr. | Baseline | 3 Yr. | Baseline | 3 Yr. | Baseline | 3 Yr. | Baseline | 3 Yr. | Baseline | 3 Yr. | Baseline | 3 Yr. | Baseline | 3 Yr. | 3 Yr. | 3 Yr. |
| | 1 | 6 | Yes | No | No | No | No | No | 0 | 260 | * | 84 | 252 | 240 | No | Yes | No | No | Mildly worse | Yes | | 3 | 13 | Yes | No | Yes | No | Yes | No | 0 | 300 | * | 63 | 165 | 342 | No | No | No | Yes | Moderately improved | Yes | | 4 | 7 | Yes | No | No | No | Yes | No | 0 | 270 | * | 66 | 200 | 316 | No | Yes | No | Yes | Markedly improved | Yes | | 5 | 6 | Yes | No | Yes | No | No | No | 0 | 75 | * | 60 | 48 | 134 | Yes | Yes | No | No | Slightly improved | Yes | | 6 | 17 | Yes | No | No | No | No | No | 0 | 360 | * | 95 | 350 | 428 | Yes | Yes | Yes | Yes | No change | Yes | | 8 | 8 | Yes | No | Yes | No | Yes | No | 22.5 | 225 | * | 64 | 189 | 212 | Yes | Yes | No | Yes | Markedly improved | Yes | | 10 | 15 | Yes | No | Yes | No | Yes | No | 200 | 380 | 32 | 97 | 324 | 391 | No | Yes | Yes | Yes | No change | Yes | | 2 | 7 | Yes | * | Yes | * | Yes | * | 0 | * | * | * | 200 | * | No | * | No | * | * | No | | 7 | 8 | Yes | * | Yes | * | Yes | * | 0 | * | * | * | 226 | * | No | * | No | * | * | No | | 9 | 37 | Yes | Yes | No | Yes | Yes | Yes | 26.6 | 30 | * | 8 | 269 | 377 | No | Yes | No | No | Slightly improved | No | | 11 | 7 | Yes | Yes | Yes | No | No | No | 5 | 0 | 3 | 0 | 167 | 219 | No | No | No | No | No change | No | | 12 | 6 | Yes | * | No | * | No | * | 0 | * | 0 | * | 101 | * | Yes | * | No | * | * | No | | 11 | Yes | No | No | No | Yes | Yes | 40 | 219 | 13.5 | 47 | 284 | 252 | No | No | No | No | No change | No |
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MCC: maximum cystometric capacity; NDO: neurogenic detrusor overactivity; CIC: clean intermittent catheterization >1x/day; UI: urinary incontinence; PVR: post-void residual; GRA: Global Response Assessment.
†On voiding diary at baseline for subjects 1–9; on uroflow at 3 yr.
*Missing data.
‡Tethered cord at 3 yr. visit.
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