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Advances in Urology
Volume 2014, Article ID 984382, 4 pages
Clinical Study

Diethylstilbestrol 1 mg in the Treatment of Acute Urinary Retention due to Prostatic Obstruction in the Elderly: A Preliminary Study

1Faculty of Medicine, Pontifical Catholic University of Campinas (PUC-Campinas), 13060-904 Campinas, SP, Brazil
2Urology Division, Pontifical Catholic University of Campinas (PUC-Campinas), 13060-904 Campinas, SP, Brazil
3Faculty of Medicine and Urology Division, University of Campinas (Unicamp), 13083-887 Campinas, SP, Brazil

Received 31 July 2013; Revised 7 November 2013; Accepted 24 November 2013; Published 19 January 2014

Academic Editor: James A. Brown

Copyright © 2014 Leonardo Oliveira Reis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Patients who failed a catheter-free trial after acute urinary retention and one week of full dose alpha-blocker and 5-alpha-reductase inhibitor were offered Diethylstilbestrol 1 mg plus Aspirin 100 mg over 4 weeks. Prostate volume, age, serum creatinine, and initial retention drained urine volume were recorded. After excluding cardiovascular morbidity (), upper urinary tract dilation (), compromised renal function (), urinary tract infection (), neurological diagnosis (), or preferred immediate channel transurethral resection of prostate (), 48 of 69 consecutive patients ≥70 years were included. Mean age was 76.6 years (70–84), mean prostate volume 90 cm3 (42–128), and mean follow-up 204 days; 58% (28/48) were passing urine and 42% (20/48) were catheter dependent after 4 weeks Diethylstilbestrol trial. Mean age and drained urine volume of catheter dependent patients were 82.4 years and 850 mL compared with 74.6 years and 530 mL in catheter-free men, respectively. Age and drained urine volume were independent predictors of catheter-free trial (both ). Seventy-five percent (6/8) of patients 80 years and older were catheter dependent. Transient nipple/breast tenderness and gynecomastia were the only adverse effects reported by 21% (10/48) and 4% (2/48), respectively. No patient presented severe complications.