Advances in Urology / 2015 / Article / Tab 4

Review Article

A Narrative Review on the Pathophysiology and Management for Radiation Cystitis

Table 4

The proposed intravesical treatments for radiation cystitis and their levels of evidence.

Intravesical agentLevel of evidenceData

Botulinum toxin A4Increase in bladder capacity
Reduction in urinary frequency from 14 to 11 episodes
No side effects reported [19]

Hyaluronic acid1bSignificant reduction in voiding frequency
Significant reduction in pelvic pain
Reduction of haematuria equal to that of hyperbaric oxygen
Side effects: increased rate of UTIs at 6 months [20]

Chondroitin sulfate2bReduction in self-reported bladder symptoms
No side effects reported [21]

Formalin4Significant reduction in haematuria
High complication rate including mortality [2224]

Polydeoxyribonucleotides3Improvement in reported cystitis symptoms [25]

Early placental extract3BSymptomatic improvement in radiation cystitis
Cystoscopic improvement in radiation cystitis [26]

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