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Advances in Urology
Volume 2016 (2016), Article ID 3140372, 5 pages
http://dx.doi.org/10.1155/2016/3140372
Review Article

From Inflammation to Prostate Cancer: The Role of Inflammasomes

Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, SC 29208, USA

Received 23 March 2016; Revised 17 May 2016; Accepted 9 June 2016

Academic Editor: Mohammad H. Ather

Copyright © 2016 Dev Karan and Seema Dubey. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Inflammation-associated studies entice specific attention due to inflammation’s role in multiple stages of prostate cancer development. However, mechanistic regulation of inflammation inciting prostate cancer remains largely uncharacterized. A focused class of inflammatory regulators known as inflammasomes has recently gained attention in cancer development. Inflammasomes are a multiprotein complex that drives a cascade of proinflammatory cytokines regulating various cellular activities. Inflammasomes activation is linked with infection, stress, or danger signals, which are common events within the prostate gland. In this study, we review the potential of inflammasomes in understanding the role of inflammation in prostate cancer.