Distribution of Neuroendocrine Cells in the Transition Zone of the Prostate

Figure 1

(a) NE cells in the transition zone of a dorsal section obtained from a radical prostatectomy specimen were evaluated. TZ: transition zone, PZ: peripheral zone, U: lumen of urethra. (b–e) Group A. (f–i) Group B. (j–m) Group C. (b), (f), and (j) Gross anatomy and histology of a dorsal prostate section containing verumontanum (hematoxylin and eosin staining). (c), (g), and (k) Transition zone. (g) In group B, the TZ included 2 areas, intra-adenoma and extra-adenoma, which are divided by a dotted line. Intra-adenoma, extra-adenoma. (d), (h) and (l) Immunoreactivity against chromogranin A. (e), (i), and (m) Chromogranin A-positive cells in the transition zone were manually dotted. (n) High magnification of chromogranin A-positive NE cells in the intra-adenoma area of a group B patient. (o) High magnification of chromogranin A-positive NE cells in the extra-adenoma area of a group B patient. Scale bars: (b–m), 4 mm; (n) and (o), 200 μm.