Efficacy of Transdermal Oxybutynin in the Treatment of Overactive Bladder Syndrome: Does It Make Sense Using It in 2017?

Table 4

Changes 3D from baseline in the 3 DVD at 12 months of treatment with OXY-TDS (patients < 65 years and ≥65 years).

3 DVD	<65 years (); mean (SD)	≥65 years (); mean (SD)	Diff (95% CI)	value
DUF (episodes/day)	6.83 (1.5)	7.2 (1.9)	−0.3 (−1.3; 0.7)	0.615
NUF (episodes/night)	0.6 (0.7)	1.1 (0.9)	−0.3 (−1.3; 0.0)	0.053
UF/24 h (episodes/day)	7.4 (1.6)	8.4 (2.2)	−0.7 (−2.0; 0.3)	0.129
Maximum UV (ml)	373.5 (328.4)	284.0 (203.7)	40.0 (−26.7; 106.7)	0.221
Nocturnal UV (ml)	107.4 (109.2)	194.6 (194.4)	−87.2 (−188.3; 14.0)	0.089
Mean UV (ml)	205.5 (54.9)	191 (n/a)	—	—
Urgency (episodes/day)	1.5 (1.6)	1.5 (1.2)	−0.1 (−1.0; 0.9)	0.876
Urgency grade	2.3 (1.3)	2.3 (1.4)	0.0 (−0.7; 0.7)	0.805
UUI (episodes/day)	0.3 (0.5)	0.87 (1.4)	0.0 (−0.7; 0.0)	0.232
SUI (episodes/day)	0.1 (0.2)	0.3 (0.9)	0.0 (0.0; 0.0)	0.514
Pad/underwear changes (number/day)	0.4 (0.6)	1.5 (1.5)	−0.7 (−2.0; 0.0)	0.024
Liquid intake/24 h (ml)	1431.2 (522.3)	1508.2 (531.3)	−77.0 (−457.8; 303.7)	0.684
Urine output/24 h (ml)	1503.4 (377.6)	1506.8 (405.3)	−3.4 (−274.9; 268.1)	0.980
Nocturnal urine output (ml)	127.0 (132.7)	309.2 (282.4)	−182.3 (−317.7; 46.8)	0.063

3 DVD: 3-day voiding diary; DUF: daytime urinary frequency; NUF: night-time urinary frequency; SD: standard deviation; SUI: stress urinary incontinence; UF/24 h: 24-hour urinary frequency (total number of episodes/24 hours); UV: urinary volume; UUI: urge urinary incontinence. values: Student’s t-test or Wilcoxon signed rank test. Change: mean difference or Hodges-Lehman estimator of location shift.