Conventional-Dose versus High-Dose Chemotherapy for Relapsed Germ Cell Tumors

Figure 1

Study design of the TIGER trial (Alliance 0311012; EORTC 1407). POD, progression of disease; HDCT/ASCT, high-dose chemotherapy with autologous stem cell transplant; TIP, paclitaxel, ifosfamide, and cisplatin; TI-CE, paclitaxel and ifosfamide followed by high-dose carboplatin and etoposide; IPFSG, International Prognostic Factors Study Group; PFS, progression-free survival; response rate; CR, complete response; PR-m, partial response with normal tumor markers; TRM, treatment-related mortality; QOL, quality of life.