The T-Cell Immune Response against Kaposi's Sarcoma-Associated Herpesvirus

Table 1

Known immunogenic KSHV open reading frames (ORFs) and CD4 and CD8 epitopes.

T-cell subtype	Expression	KSHV ORF	Epitope position	Epitope sequence	HLA restriction	Other responsive HLA types	Reference
Not determined	Latent(?) and lytic	K10.5	Not determined	Not determined	N/A	N/A	[20]
CD4	Latent and induced in lytic cycle	K12	aa46–60	RGPVAFRTRVATGAH	Not determined	N/A	[22]
		K15	aa171–185	GNIKLVSSVSFICAG	Not determined	N/A	[22]
CD4	Late lytic	K8.1	Not determined	Not determined	N/A	N/A	[29]
CD8	Latent	ORF 73	aa71–79	FTSGLPAFV	A2	A26/A29	[22]
			aa140–148	PESSQRPPL	A*0201	None identified	[24]
			aa238–246	WATESPIYV	A2	A26/A29; A39/A69	[22]
			aa281–289	AMLVLLAEI	A*0201	None identified	[24]
			aa417–425	DGGDGNKTL	A*0201	None identified	[24]
			aa688–697	QQDEQQQQDE	A*0201	None identified	[24]
			aa920–928	PVVSTHEQI	A*0201	None identified	[24]
			aa1116–1124	QMARLAWEA	A2	A26/A29; A2/A69	[22]
CD8	Latent and induced in lytic cycle	K12	aa17–25	LLNGWRWRL	A*0201	None identified	[21]
			aa16–25	VLLNGWRWRL	A2	None identified	[25]
			aa23–32	WRLGAIPPLV	A*0201	None identified	[24]
			aa31–45	LVCLLAISVVPPSGQ	B7	B7/B53; B7/B14;	[22]
						B35/B49; B7/B51
		K15	aa123–131	ILFTSTFAV	A2	A2/A24	[22]
			aa155–163	FTLSLPFLY	B44	B44/B49	[22]
			aa166–175	ATVKTGNIKL	B7	None identified	[30]
CD8	Immediate-early lytic	K5	aa154–163	ALYAANNTRV	A2	None identified	[26]
		ORF 6	aa1050–1058	VLGDEVLSL	A*0201	None identified	[23]
		ORF 57	aa212–220	ISARGQELF	B57	B58?	[20]
CD8	Early lytic	K3	aa72–81	LPRLTYQEGL	B7	None identified	[26]
			aa96–105	GLAAATWVWL	A2	None identified	[26]
			aa127–137	FVFYQLFVV	A2	None identified	[26]
		ORF 8	aa159–168	SSMKVNVNGV	A*0201	None identified	[24]
			aa492–500	LMWYELSKI	A2	None identified	[27]
			aa736–745	MLMIIIVIAI	A*0201	None identified	[24]
		ORF 61	aa505–513	GLADVFAEL	A*0201	None identified	[23]
		ORF 65	aa35–43	NMSQAEYLV	A*0201	None identified	[23]
		ORF 70	aa108–116	VVQELLWFL	A2	None identified	[26]
			aa255–264	SLLTYMLAHV	A2	None identified	[26]
			aa259–267	YMLAHVTGL	A2	None identified	[26]
			aa236–245	LYQRSGDMGL	A24	None identified	[26]
			aa253–261	SYSLLTYML	A24	None identified	[26]
			aa296–305	TPRPFPRLEI	B7	None identified	[26]
CD8	Late lytic	K1	aa58–66	FRLTERTLF	Cw3	None identified	[19]
			aa82–90	HRQSIWITW	B*2702	None identified	[19]
			aa91–99	YPQPVLQTL	B51	None identified	[19]
			aa93–101	QPVLQTLCA	B55	None identified	[19]
		K8.1	aa73–81	RLAAGSPSS	A*0201	None identified	[24]
			aa131–145	ELTDALISAFSGSYS	A24	None identified	[28]
			aa135–143	ALISAFSGS	A*0201	None identified	[24]
			aa211–225	LILYLCVPRCRRKKP	Not determined	N/A	[28]
			aa209–217	LVLILYLCV	A2	None identified	[11]
		ORF 22	aa59–68	FLNWQNLLNV	A2	None identified	[25]
		ORF 25	Not determined	Not determined	N/A	N/A	[18]
		ORF 26	aa103–111	FQWDSNTQL	A2	None identified	[26]
			aa125–134	IVLESNGFDL	A2	None identified	[26]
			aa203–211	VLDDLSMYL	A2	None identified	[26]