Review Article
The T-Cell Immune Response against Kaposi's Sarcoma-Associated Herpesvirus
Table 1
Known immunogenic KSHV open reading frames (ORFs) and CD4 and CD8 epitopes.
| T-cell subtype | Expression | KSHV ORF | Epitope position | Epitope sequence | HLA restriction | Other responsive HLA types | Reference |
| Not determined | Latent(?) and lytic | K10.5 | Not determined | Not determined | N/A | N/A | [20] |
| CD4 | Latent and induced in lytic cycle | K12 | aa46–60 | RGPVAFRTRVATGAH | Not determined | N/A | [22] | | | K15 | aa171–185 | GNIKLVSSVSFICAG | Not determined | N/A | [22] |
| CD4 | Late lytic | K8.1 | Not determined | Not determined | N/A | N/A | [29] |
| CD8 | Latent | ORF 73 | aa71–79 | FTSGLPAFV | A2 | A26/A29 | [22] | | | | aa140–148 | PESSQRPPL | A*0201 | None identified | [24] | | | | aa238–246 | WATESPIYV | A2 | A26/A29; A39/A69 | [22] | | | | aa281–289 | AMLVLLAEI | A*0201 | None identified | [24] | | | | aa417–425 | DGGDGNKTL | A*0201 | None identified | [24] | | | | aa688–697 | QQDEQQQQDE | A*0201 | None identified | [24] | | | | aa920–928 | PVVSTHEQI | A*0201 | None identified | [24] | | | | aa1116–1124 | QMARLAWEA | A2 | A26/A29; A2/A69 | [22] |
| CD8 | Latent and induced in lytic cycle | K12 | aa17–25 | LLNGWRWRL | A*0201 | None identified | [21] | | | | aa16–25 | VLLNGWRWRL | A2 | None identified | [25] | | | | aa23–32 | WRLGAIPPLV | A*0201 | None identified | [24] | | | | aa31–45 | LVCLLAISVVPPSGQ | B7 | B7/B53; B7/B14; | [22] | | | | | | | B35/B49; B7/B51 | | | | K15 | aa123–131 | ILFTSTFAV | A2 | A2/A24 | [22] | | | | aa155–163 | FTLSLPFLY | B44 | B44/B49 | [22] | | | | aa166–175 | ATVKTGNIKL | B7 | None identified | [30] |
| CD8 | Immediate-early lytic | K5 | aa154–163 | ALYAANNTRV | A2 | None identified | [26] | | | ORF 6 | aa1050–1058 | VLGDEVLSL | A*0201 | None identified | [23] | | | ORF 57 | aa212–220 | ISARGQELF | B57 | B58? | [20] |
| CD8 | Early lytic | K3 | aa72–81 | LPRLTYQEGL | B7 | None identified | [26] | | | | aa96–105 | GLAAATWVWL | A2 | None identified | [26] | | | | aa127–137 | FVFYQLFVV | A2 | None identified | [26] | | | ORF 8 | aa159–168 | SSMKVNVNGV | A*0201 | None identified | [24] | | | | aa492–500 | LMWYELSKI | A2 | None identified | [27] | | | | aa736–745 | MLMIIIVIAI | A*0201 | None identified | [24] | | | ORF 61 | aa505–513 | GLADVFAEL | A*0201 | None identified | [23] | | | ORF 65 | aa35–43 | NMSQAEYLV | A*0201 | None identified | [23] | | | ORF 70 | aa108–116 | VVQELLWFL | A2 | None identified | [26] | | | | aa255–264 | SLLTYMLAHV | A2 | None identified | [26] | | | | aa259–267 | YMLAHVTGL | A2 | None identified | [26] | | | | aa236–245 | LYQRSGDMGL | A24 | None identified | [26] | | | | aa253–261 | SYSLLTYML | A24 | None identified | [26] | | | | aa296–305 | TPRPFPRLEI | B7 | None identified | [26] | CD8 | Late lytic | K1 | aa58–66 | FRLTERTLF | Cw3 | None identified | [19] | | | | aa82–90 | HRQSIWITW | B*2702 | None identified | [19] | | | | aa91–99 | YPQPVLQTL | B51 | None identified | [19] | | | | aa93–101 | QPVLQTLCA | B55 | None identified | [19] | | | K8.1 | aa73–81 | RLAAGSPSS | A*0201 | None identified | [24] | | | | aa131–145 | ELTDALISAFSGSYS | A24 | None identified | [28] | | | | aa135–143 | ALISAFSGS | A*0201 | None identified | [24] | | | | aa211–225 | LILYLCVPRCRRKKP | Not determined | N/A | [28] | | | | aa209–217 | LVLILYLCV | A2 | None identified | [11] | | | ORF 22 | aa59–68 | FLNWQNLLNV | A2 | None identified | [25] | | | ORF 25 | Not determined | Not determined | N/A | N/A | [18] | | | ORF 26 | aa103–111 | FQWDSNTQL | A2 | None identified | [26] | | | | aa125–134 | IVLESNGFDL | A2 | None identified | [26] | | | | aa203–211 | VLDDLSMYL | A2 | None identified | [26] |
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