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Advances in Virology
Volume 2010, Article ID 368068, 9 pages
Review Article

Novel Roles of the Picornaviral 3D Polymerase in Viral Pathogenesis

1Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
2Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA

Received 25 March 2010; Accepted 26 May 2010

Academic Editor: George N. Pavlakis

Copyright © 2010 Jason Kerkvliet et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The RNA-dependent RNA-polymerase, , is an essential component in the picornavirus genome for the replication of single stranded RNA. However, transgenic expression of in mice has antiviral effects. Here, we discuss the structure and function of during picornavirus replication, we review the evidence and consequence of a host immune response to epitopes in after picornavirus infection, highlight data showing the antiviral effects of transgenic from Theiler's murine encephalomyelitis virus (TMEV), and discuss potential mechanisms by which is causing this antiviral effect in mice.