Novel Roles of the Picornaviral 3D Polymerase in Viral Pathogenesis

Figure 1

Genomic organization of picornaviruses with the covalently linked VPg peptide as it is packaged in the virion. The regions of the P1 (pink), P2 (blue), and P3 (brown) are shown along with the viral proteins encoded within each domain. P1 encodes capsid proteins and the P2 and P3 domains encode noncapsid proteins used for protein processing and replication. The plus-sense single stranded RNA genome is translated into a single polyprotein and then cleaved by cis and transacting viral proteases.