HIV Drug Resistance-Associated Mutations in Antiretroviral Naïve HIV-1-Infected Latin American Children
Table 1
Characteristics of study population overall and according to whether or not DRMs were detected.
Characteristic
Overall
DRMs detected
No DRMs detected
P value*
Number of subjects
69
6 (8.7%)
63
Country of origin:
Argentina
5 (7.2%)
0 (0.0%)
5
0.74
Brazil
55 (79.7%)
6 (10.9%)
49
Mexico
9 (13.0%)
0 (0.0%)
9
Age at enrollment (years):
Mean (SD)
7.3 (6.0)
5.2 (0.8)
7.5 (6.2)
0.64
Median
6.0
5.0
6.0
Gender:
Female
40 (58.0%)
3 (7.5%)
37
0.69
Male
29 (42.0%)
3 (10.3%)
26
Subject’s risk for HIV infection:
Blood product transfusion
1 (1.5%)
0 (0.0%)
1
1.00
Consensual sexual contact
8 (11.6%)
0 (0.0%)
8
Perinatal exposure
56 (81.2%)
6 (10.7%)
50
Unknown
4 (5.8%)
0 (0.0%)
4
Among perinatally infected, did mother take ARVs during pregnancy or at labor and delivery?
Yes
7 (12.5%)
0 (0.0%)
7
0.55
No
44 (78.6%)
5 (11.4%)
39
Unknown
5 (8.9%)
1 (1.8%)
4
CD4 percent at or nearest to the time when the resistance testing specimen was collected:
Mean (SD)
24.2 (10.9)
25.2 (8.6)
24.1 (11.2)
0.42
Median
24.0
28.0
23.0
15%
11 (17.5%)
1 (9.1%)
10
0.64
15–24.9%
23 (36.5%)
1 (4.3%)
22
25%
29 (46.0%)
4 (13.8%)
25
Missing
6
0
6
CD4 absolute count (cells/mm3) at or nearest to the time when the resistance testing specimen was collected:
Mean (SD)
779 (615)
769 (354)
780 (637)
0.65
Median
668
678
668
<200 cells/mm3
9 (13.2%)
0 (0.0%)
9
0.84
200–500
16 (23.5%)
1 (6.3%)
15
>500
43 (63.2%)
5 (11.6%)
38
Missing
1
0
1
CDC clinical classification:
Category N
18 (26.5%)
4 (22.2%)
14
0.09
Category A
9 (13.2%)
1 (11.1%)
8
Category B
4 (5.9%)
0 (0.0%)
4
Category C
37 (54.4%)
1 (2.7%)
36
Missing
1
0
1
HIV-1 viral load (copies/mL) at or nearest to the time when the resistance testing specimen was collected:
Mean
214,448
34,062
232,191
0.25
SD
522,665
31,248
544,831
Median
40,100
25,521
44,000
Vital status of study subject:
Dead
1 (1.4%)
0 (0.0%)
1
1.00
Alive
68 (98.6%)
6 (8.8%)
62
*The significance of associations of categorical characteristics with DRMs was determined based on Fisher’s Exact test, while the association with continuous scaled characteristics was based on the Student’s t-test (log10-transformed viral load) or nonparametric testing (Wilcoxon test).
