Towards Inhibition of Vif-APOBEC3G Interaction: Which Protein to Target?
Figure 1
Schematic representation of Vif and A3G domains involved in the interaction of both proteins. (a) Vif binds A3G through specific residues located in the N-terminal region. Amino acids in Vif that are involved in the interaction with A3G are shown in pink. C-terminal Vif domains involved in targeting A3G for proteasomal degradation are shown in orange (zinc binding HCCH domain), and light blue (SLQXLA). The multimerization domain is purple. (b) The catalytic domains (CD1 and CD2) and Vif-binding regions of A3G protein are represented. Amino acids 126–132 are involved in A3G encapsidation and interaction with Vif and are represented in green and red.
