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Advances in Virology
Volume 2011, Article ID 109849, 8 pages
Review Article

The Paradox of Feline Coronavirus Pathogenesis: A Review

1Laboratório de Infectologia Molecular Animal (LIMA), Universidade Federal de Viçosa, Avenida Peter Henry Rolfs, s/n Campus Universitário, 36570-000 Vicosa, MG, Brazil
2Laboratório de Doença das Aves, Universidade Federal de Minas Gerais, Avenida Antônio Carlos, 6627—Pampulha, 31270-901, Belo Horizonte, MG, Brazil

Received 1 December 2010; Revised 1 June 2011; Accepted 1 June 2011

Academic Editor: Michael Bukrinsky

Copyright © 2011 Luciana Wanderley Myrrha et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Feline coronavirus (FCoV) is an enveloped single-stranded RNA virus, of the family Coronaviridae and the order Nidovirales. FCoV is an important pathogen of wild and domestic cats and can cause a mild or apparently symptomless enteric infection, especially in kittens. FCoV is also associated with a lethal, systemic disease known as feline infectious peritonitis (FIP). Although the precise cause of FIP pathogenesis remains unclear, some hypotheses have been suggested. In this review we present results from different FCoV studies and attempt to elucidate existing theories on the pathogenesis of FCoV infection.