Arenavirus Budding

Table 1

Summary of different matrix (M) protein L domain motifs and cellular-interacting partners. Characterized viral M proteins, accessory proteins, and their L domains are shown. *1: Alix/AIP1 has been shown to connect Z and NP [45, 46]. *2: there is a discrepancy between the groups for Alix/AIP1 and Vps4 necessity for the budding [34, 35, 47].

Virus	M protein	Accessary protein	L domain	Nedd4-like Ubiquitin ligase	Tsg101	Alix/AIP1	Vps4
HIV-1	Gag		PTAP	○	○		○
			YPXnL			○
RSV	Gag		PPPY	○			○
			YPXnL
VSV	M		PTAP		x		x
			PPPY	○
Ebola virus	VP40		PTAP		○		○
			PPPY	○
Marburg virus	VP40		PPPY	○	○		○
		NP	PSAP		○
Lassa virus	Z		PTAP		○		○
			PPPY
LCMV	Z		PPPY		○		○
Tacaribe virus	Z		ASAP		x		○
Mopeia virus	Z		PTAP			○*1
			PPPY
		NP
Sendai virus	M		YLDL			○*2	○*2
		C				○*2
Influenza virus							x