A Systemic Network Triggered by Human Cytomegalovirus Entry
Figure 1
A comprehensive regulatory network linked to HCMV entry. The network was constructed by using protein-protein binding database and protein functional database (see text and Section 4 for details). The insert shows a zoomed portion of entire network. The colors of nodes (proteins) and edges (interactions) represent gene expression levels (red color-upregulation, green color-downregulation compared with mock-control) and edge sources, respectively. The same color strategy for nodes and edges will be used for all figures in this study unless otherwise specified. Also shown are entire network properties, including node degree distribution that approximates a power law, ( in our network), and distribution, average clustering coefficient that measures the tendency of nodes to form clusters, which decreases with the number of neighbors.
