Association of Influenza Virus Proteins with Membrane Rafts
Figure 2
Schematic representation of influenza virus budding. (a) Formation of the budozone, a coalesced raft domain, in the plasma membrane. HA (blue) and NA (not shown) are targeted to rafts; M2 (purple) might be positioned at the edge of the budozone. M1 (red) binds to membranes and all the viral proteins including the viral RNPs (not shown) and clusters the viral components. The cytoskeleton (cyan) is involved in establishment of the budozone. (b) Formation of curvature for budding. Interactions involved: M1 acts as a scaffold from beneath, the cytoskeleton provides outward pushing, the line tension at the domain boundary leads to bending, and the amphiphilic helix of M2 acts as a wedge. See text for details.
