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Advances in Virology
Volume 2011, Article ID 609465, 11 pages
Review Article

Feline and Canine Coronaviruses: Common Genetic and Pathobiological Features

UMR 1161 INRA-ENVA-ANSES, 7 avenue Général de Gaulle, 94704 Maisons-Alfort, France

Received 12 December 2010; Revised 3 March 2011; Accepted 18 May 2011

Academic Editor: Peter J. M. Rottier

Copyright © 2011 Sophie Le Poder. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A new human coronavirus responsible for severe acute respiratory syndrome (SARS) was identified in 2003, which raised concern about coronaviruses as agents of serious infectious disease. Nevertheless, coronaviruses have been known for about 50 years to be major agents of respiratory, enteric, or systemic infections of domestic and companion animals. Feline and canine coronaviruses are widespread among dog and cat populations, sometimes leading to the fatal diseases known as feline infectious peritonitis (FIP) and pantropic canine coronavirus infection in cats and dogs, respectively. In this paper, different aspects of the genetics, host cell tropism, and pathogenesis of the feline and canine coronaviruses (FCoV and CCoV) will be discussed, with a view to illustrating how study of FCoVs and CCoVs can improve our general understanding of the pathobiology of coronaviruses.