Endogenous Murine Leukemia Viruses: Relationship to XMRV and Related Sequences Detected in Human DNA Samples

Figure 4

Recombination between PreXMRV-1 and -2 leads to XMRV. The sequences of the two proviruses identified by Paprotka et al. are shown schematically, with a vertical line indicating each position that differs from the XMRV consensus. The red line shows the positions of the 6 crossover events (common during retrovirus replication) that are inferred to have given rise to a virus differing from XMRV at only the 4 positions shown. Modified from Paprotka et al. [19].