Naturally Occurring Polymorphisms of the Mouse Gammaretrovirus Receptors CAT-1 and XPR1 Alter Virus Tropism and Pathogenicity

Table 1

Functional variants of the XPR1 receptor in Mus.

	Infectivity^a				Distribution^b
	X-MLV	P-MLV	CasE#1	Cz524	Common laboratory strains	Mus Species
Xpr1^n	−	+++	−	−	Most	None
Xpr1^sxv	+++	+++	+++	+++	F/St, LT, LP, SWR, SJL, SIM.R, SOD1	Most
Xpr1^p	+++	−	+++	−	None	M. pahari
Xpr1^c	++	−	−	+	None	M. castaneus
Xpr1^m	++	−	−	−	None	M. musculus,; M. molossinus

^aMeasured as log₁₀ titer of FFU/100 𝜇L of viral Env pseudotypes carrying the LacZ reporter. Log₁₀ titer: +++, >3; ++, 2-3; +, 1-2; −, 0-1.
^bDetermined for ~50 of the common strains of laboratory mice and ~20 of the 40 species of Mus [17, 95].