Advances in Virology / 2012 / Article / Fig 1

Review Article

Immunopathogenic and Neurological Mechanisms of Canine Distemper Virus

Figure 1

Schematic representation of the possible mechanisms involved in the demyelination process in the course of acute canine distemper disease. (a) Primary demyelination: direct action of CDV on oligodendrocytes. (b) Secondary demyelination: indirect action of CDV on oligodendrocytes and myelin sheath. CDV: canine distemper virus; PBM: myelin basic protein; ROS: reactive oxygen species (free radicals).
163860.fig.001a
(a)
163860.fig.001b
(b)

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