Advances in Virology / 2012 / Article / Fig 1

Review Article

Immunopathogenic and Neurological Mechanisms of Canine Distemper Virus

Figure 1

Schematic representation of the possible mechanisms involved in the demyelination process in the course of acute canine distemper disease. (a) Primary demyelination: direct action of CDV on oligodendrocytes. (b) Secondary demyelination: indirect action of CDV on oligodendrocytes and myelin sheath. CDV: canine distemper virus; PBM: myelin basic protein; ROS: reactive oxygen species (free radicals).

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.