Immunopathogenic and Neurological Mechanisms of Canine Distemper Virus
Schematic representation of the possible mechanisms involved in the demyelination process in the course of acute canine distemper disease. (a) Primary demyelination: direct action of CDV on oligodendrocytes. (b) Secondary demyelination: indirect action of CDV on oligodendrocytes and myelin sheath. CDV: canine distemper virus; PBM: myelin basic protein; ROS: reactive oxygen species (free radicals).
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