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Advances in Virology
Volume 2012 (2012), Article ID 384069, 6 pages
Features of Human Herpesvirus-6A and -6B Entry
1Division of Clinical Virology, Kobe University Graduate School of Medicine, Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
2Laboratory of Virology and Vaccinology, Division of Biomedical Research, National Institute of Biomedical Innovation, 7-6-8 Saito-Asagi, Ibaraki, Osaka 567-0085, Japan
Received 1 August 2012; Accepted 25 September 2012
Academic Editor: Anthony V. Nicola
Copyright © 2012 Takahiro Maeki and Yasuko Mori. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- S. A. Connolly, J. O. Jackson, T. S. Jardetzky, and R. Longnecker, “Fusing structure and function: a structural view of the herpesvirus entry machinery,” Nature Reviews Microbiology, vol. 9, no. 5, pp. 369–381, 2011.
- S. Z. Salahuddin, D. V. Ablashi, and P. D. Markham, “Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders,” Science, vol. 234, no. 4776, pp. 596–601, 1986.
- D. V. Ablashi, N. Balachandran, S. F. Josephs et al., “Genomic polymorphism, growth properties, and immunologic variations in human herpesvirus-6 isolates,” Virology, vol. 184, no. 2, pp. 545–552, 1991.
- J. T. Aubin, H. Collandre, D. Candotti et al., “Several groups among human herpesvirus 6 strains can be distinguished by Southern blotting and polymerase chain reaction,” Journal of Clinical Microbiology, vol. 29, no. 2, pp. 367–372, 1991.
- B. Chandran, S. Tirawatnapong, B. Pfeiffer, and D. V. Ablashi, “Antigenic relationships among human herpesvirus-6 isolates,” Journal of Medical Virology, vol. 37, no. 4, pp. 247–254, 1992.
- Y. Isegawa, T. Mukai, K. Nakano et al., “Comparison of the complete DNA sequences of human herpesvirus 6 variants A and B,” Journal of Virology, vol. 73, no. 10, pp. 8053–8063, 1999.
- U. A. Gompels, J. Nicholas, G. Lawrence et al., “The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution,” Virology, vol. 209, no. 1, pp. 29–51, 1995.
- G. Dominguez, T. R. Dambaugh, F. R. Stamey, S. Dewhurst, N. Inoue, and P. E. Pellett, “Human herpesvirus 6B genome sequence: coding content and comparison with human herpesvirus 6A,” Journal of Virology, vol. 73, no. 10, pp. 8040–8052, 1999.
- K. Yamanishi, T. Okuno, K. Shiraki et al., “Identification of human herpesvirus-6 as a causal agent for exanthem subitum,” Lancet, vol. 1, no. 8594, pp. 1065–1067, 1988.
- M. Portolani, M. Pecorari, M. G. Tamassia, W. Gennari, F. Beretti, and G. Guaraldi, “Case of fatal encephalitis by HHV-6 variant A,” Journal of Medical Virology, vol. 65, no. 1, pp. 133–137, 2001.
- L. Potenza, M. Luppi, P. Barozzi et al., “HHV-6A in syncytial giant-cell hepatitis,” New England Journal of Medicine, vol. 359, no. 6, pp. 593–602, 2008.
- J. Chi, B. Gu, and C. Zhang, “Human herpesvirus 6 latent infection in patients with glioma,” Journal of Infectious Diseases, vol. 206, no. 9, pp. 1394–1398, 2012.
- N. Akhyani, R. Berti, M. B. Brennan et al., “Tissue distribution and variant characterization of human herpesvirus (HHV)-6: increased prevalence of HHV-6A in patients with multiple sclerosis,” Journal of Infectious Diseases, vol. 182, no. 5, pp. 1321–1325, 2000.
- F. Santoro, P. E. Kennedy, G. Locatelli, M. S. Malnati, E. A. Berger, and P. Lusso, “CD46 is a cellular receptor for human herpesvirus 6,” Cell, vol. 99, no. 7, pp. 817–827, 1999.
- P. Akkapaiboon, Y. Mori, T. Sadaoka, S. Yonemoto, and K. Yamanishi, “Intracellular processing of human herpesvirus 6 glycoproteins Q1 and Q2 into tetrameric complexes expressed on the viral envelope,” Journal of Virology, vol. 78, no. 15, pp. 7969–7983, 2004.
- Y. Mori, “Recent topics related to human herpesvirus 6 cell tropism,” Cellular Microbiology, vol. 11, no. 7, pp. 1001–1006, 2009.
- H. Tang, M. Hayashi, T. Maeki, K. Yamanishi, and Y. Mori, “Human herpesvirus 6 glycoprotein complex formation is required for folding and trafficking of the gH/gL/gQ1/gQ2 complex and its cellular receptor binding,” Journal of Virology, vol. 85, no. 21, pp. 11121–11130, 2011.
- Y. Mori, X. Yang, P. Akkapaiboon, T. Okuno, and K. Yamanishi, “Human herpesvirus 6 variant A glycoprotein H-glycoprotein L-glycoprotein Q complex associates with human CD46,” Journal of Virology, vol. 77, no. 8, pp. 4992–4999, 2003.
- Y. Mori, P. Akkapaiboon, S. Yonemoto et al., “Discovery of a second form of tripartite complex containing gH-gL of human herpesvirus 6 and observations on CD46,” Journal of Virology, vol. 78, no. 9, pp. 4609–4616, 2004.
- F. Santoro, H. L. Greenstone, A. Insinga et al., “Interaction of glycoprotein H of human herpesvirus 6 with the cellular receptor CD46,” Journal of Biological Chemistry, vol. 278, no. 28, pp. 25964–25969, 2003.
- T. Seya, A. Hirano, M. Matsumoto, M. Nomura, and S. Ueda, “Human membrane cofactor protein (MCP, CD46): multiple isoforms and functions,” International Journal of Biochemistry and Cell Biology, vol. 31, no. 11, pp. 1255–1260, 1999.
- S. Thulke, A. Radonić, A. Nitsche, and W. Siegert, “Quantitative expression analysis of HHV-6 cell receptor CD46 on cells of human cord blood, peripheral blood and G-CSF mobilised leukapheresis cells,” Virology Journal, vol. 3, article 77, 2006.
- J. Cardone, G. Le Friec, and C. Kemper, “CD46 in innate and adaptive immunity: an update,” Clinical and Experimental Immunology, vol. 164, no. 3, pp. 301–311, 2011.
- B. D. Persson, N. B. Schmitz, C. Santiago et al., “Structure of the extracellular portion of CD46 provides insights into its interactions with complement proteins and pathogens,” PLoS Pathogens, vol. 6, no. 9, Article ID e01122, 2010.
- P. E. Joubert, G. Meiffren, I. P. Grégoire et al., “Autophagy induction by the pathogen receptor CD46,” Cell Host and Microbe, vol. 6, no. 4, pp. 354–366, 2009.
- Y. Mori, T. Seya, H. L. Huang, P. Akkapaiboon, P. Dhepakson, and K. Yamanishi, “Human herpesvirus 6 variant A but not variant B induces fusion from without in a variety of human cells through a human herpesvirus 6 entry receptor, CD46,” Journal of Virology, vol. 76, no. 13, pp. 6750–6761, 2002.
- H. L. Greenstone, F. Santoro, P. Lusso, and E. A. Berger, “Human herpesvirus 6 and measles virus employ distinct CD46 domains for receptor function,” Journal of Biological Chemistry, vol. 277, no. 42, pp. 39112–39118, 2002.
- H. Tang, A. Kawabata, M. Yoshida et al., “Human herpesvirus 6 encoded glycoprotein Q1 gene is essential for virus growth,” Virology, vol. 407, no. 2, pp. 360–367, 2010.
- M. G. Revello and G. Gerna, “Human cytomegalovirus tropism for endothelial/epithelial cells: scientific background and clinical implications,” Reviews in Medical Virology, vol. 20, no. 3, pp. 136–155, 2010.
- L. M. Hutt-Fletcher, “Epstein-Barr virus entry,” Journal of Virology, vol. 81, no. 15, pp. 7825–7832, 2007.
- D. Wang and T. Shenk, “Human cytomegalovirus virion protein complex required for epithelial and endothelial cell tropism,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 50, pp. 18153–18158, 2005.
- S. M. Pedersen, B. Øster, B. Bundgaard, and P. Höllsberg, “Induction of cell-cell fusion from without by human herpesvirus 6B,” Journal of Virology, vol. 80, no. 19, pp. 9916–9920, 2006.
- S. M. Pedersen and P. Höllsberg, “Complexities in human herpesvirus-6A and -6B binding to host cells,” Virology, vol. 356, no. 1-2, pp. 1–3, 2006.
- A. Kawabata, H. Oyaizu, T. Maeki, H. Tang, K. Yamanishi, and Y. Mori, “Analysis of a neutralizing antibody for human herpesvirus 6B reveals a role for glycoprotein Q1 in viral entry,” Journal of Virology, vol. 85, no. 24, pp. 12962–12971, 2011.
- M. Cirone, C. Zompetta, A. Angeloni et al., “Infection by human herpesvirus 6 (HHV-6) of human lymphoid T cells occurs through an endocytic pathway,” AIDS Research and Human Retroviruses, vol. 8, no. 12, pp. 2031–2037, 1992.
- M. R. Torrisi, M. Gentile, G. Cardinali et al., “Intracellular transport and maturation pathway of human herpesvirus 6,” Virology, vol. 257, no. 2, pp. 460–471, 1999.
- J. Ahlqvist, D. Donati, E. Martinelli et al., “Complete replication cycle and acquisition of tegument in nucleus of human herpesvirus 6A in astrocytes and in T-cells,” Journal of Medical Virology, vol. 78, no. 12, pp. 1542–1553, 2006.
- E. Roffman, J. P. Albert, J. P. Goff, and N. Frenkel, “Putative site for the acquisition of human herpesvirus 6 virion tegument,” Journal of Virology, vol. 64, no. 12, pp. 6308–6313, 1990.
- M. Cirone, G. Campadelli-Fiume, L. Foa-Tomasi, M. R. Torrisi, and A. Faggioni, “Human herpesvirus 6 envelope glycoproteins B and H-L complex are undetectable on the plasma membrane of infected lymphocytes,” AIDS Research and Human Retroviruses, vol. 10, no. 2, pp. 175–179, 1994.
- P. Biberfeld, B. Kramarsky, S. Z. Salahuddin, and R. C. Gallo, “Ultrastructural characterization of a new human B lymphotropic DNA virus (human herpesvirus 6) isolated from patients with lymphoproliferative disease,” Journal of the National Cancer Institute, vol. 79, no. 5, pp. 933–941, 1987.
- G. Cardinali, M. Gentile, M. Cirone et al., “Viral glycoproteins accumulate in newly formed annulate lamellae following infection of lymphoid cells by human herpesvirus 6,” Journal of Virology, vol. 72, no. 12, pp. 9738–9746, 1998.
- Y. Mori, M. Koike, E. Moriishi et al., “Human herpesvirus-6 induces MVB formation, and virus egress occurs by an exosomal release pathway,” Traffic, vol. 9, no. 10, pp. 1728–1742, 2008.
- L. De Bolle, L. Naesens, and E. De Clercq, “Update on human herpesvirus 6 biology, clinical features, and therapy,” Clinical Microbiology Reviews, vol. 18, no. 1, pp. 217–245, 2005.
- S. Nii, M. Yoshida, F. Uno, T. Kurata, K. Ikuta, and K. Yamanishi, “Replication of human herpesvirus 6 (HHV-6): morphological aspects,” Advances in Experimental Medicine and Biology, vol. 278, pp. 19–28, 1990.
- H. Huang, Y. Li, T. Sadaoka et al., “Human herpesvirus 6 envelope cholesterol is required for virus entry,” Journal of General Virology, vol. 87, no. 2, pp. 277–285, 2006.
- H. Tang, A. Kawabata, M. Takemoto, K. Yamanishi, and Y. Mori, “Human herpesvirus-6 infection induces the reorganization of membrane microdomains in target cells, which are required for virus entry,” Virology, vol. 378, no. 2, pp. 265–271, 2008.
- A. Kawabata, H. Tang, H. Huang, K. Yamanishi, and Y. Mori, “Y Human herpesvirus 6 envelope components enriched in lipid rafts: evidence for virion-associated lipid rafts,” Virology Journal, vol. 6, article 127, 2009.
- P. G. Spear and R. Longnecker, “Herpesvirus entry: an update,” Journal of Virology, vol. 77, no. 19, pp. 10179–10185, 2003.
- K. Takeda, T. Okuno, Y. Isegawa, and K. Yamanishi, “Identification of a variant A-specific neutralizing epitope on glycoprotein B (gB) of human herpesvirus-6 (HHV-6),” Virology, vol. 222, no. 1, pp. 176–183, 1996.
- K. Takeda, M. Haque, T. Sunagawa, T. Okuno, Y. Isegawa, and K. Yamanishi, “Identification of a variant B-specific neutralizing epitope on glycoprotein H of human herpesvirus-6,” Journal of General Virology, vol. 78, no. 9, pp. 2171–2178, 1997.
- R. J. Eisenberg, D. Atanasiu, T. M. Cairns, J. R. Gallagher, C. Krummenacher, and G. H. Cohen, “Herpes virus fusion and entry: a story with many characters,” Viruses, no. 5, pp. 800–832, 20124.
- D. Atanasiu, W. T. Saw, G. H. Cohen, and R. J. Eisenberg, “Cascade of events governing cell-cell fusion induced by herpes simplex virus glycoproteins gD, gH/gL, and gB,” Journal of Virology, vol. 84, no. 23, pp. 12292–12299, 2010.
- G. Campadelli-Fiume, M. Amasio, E. Avitabile et al., “The multipartite system that mediates entry of herpes simplex virus into the cell,” Reviews in Medical Virology, vol. 17, no. 5, pp. 313–326, 2007.
- T. K. Chowdary, T. M. Cairns, D. Atanasiu, G. H. Cohen, R. J. Eisenberg, and E. E. Heldwein, “Crystal structure of the conserved herpesvirus fusion regulator complex gH-gL,” Nature Structural and Molecular Biology, vol. 17, no. 7, pp. 882–888, 2010.
- E. E. Heldwein, H. Lou, F. C. Bender, G. H. Cohen, R. J. Eisenberg, and S. C. Harrison, “Crystal structure of glycoprotein B from herpes simplex virus 1,” Science, vol. 313, no. 5784, pp. 217–220, 2006.
- H. Matsuura, A. N. Kirschner, R. Longnecker, and T. S. Jardetzky, “Crystal structure of the Epstein-Barr virus (EBV) glycoprotein H/glycoprotein L (gH/gL) complex,” Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 52, pp. 22641–22646, 2010.
- C. M. Borza and L. M. Hutt-Fletcher, “Alternate replication in B cells and epithelial cells switches tropism of Epstein-Barr virus,” Nature Medicine, vol. 8, no. 6, pp. 594–599, 2002.