Orthopoxvirus Genes That Mediate Disease Virulence and Host Tropism

Table 1

Orthopoxviral Bcl-2-like proteins.

Protein function	VACV-COP		CPXV-GRI		MPXV-ZAI		VARV-IND
	ORF	Size, aa	ORF	Size, aa	ORF	Size, aa	ORF	Size, aa
Inhibition of NF-𝜅B and IRF3 activation by interacting with MyD88, TIRAP and TRIF, and TRAM	A46R	214	A49R	240	A47R	240	A52R	240
Inhibition of NF-𝜅B activation by interacting with IRAK2 and TRAF6	A52R	190	A55R	190	—	—	J6R	71
Inhibition of NF-𝜅B activation by interacting with IKK complex	B15R	149	B13R	149	B13R	149	B14R	149
Inhibition of NF-𝜅B and IRF3 activation by interacting with IKK complex and TBK1, apoptosis inhibitor	N1L	117	Q1L	117	P1L	117	P1L	117
Inhibition of NF-𝜅B and IRF3 activation by interacting with IRAK2, TRAF6, and DDX3	K7R	149	M6R	149	C6R	149	C4R	149
Inhibition of IRF3 and IRF7 activation by interacting with TANK, NAP1, and SINTBAD	C6L	151	C14L	156	D11L	153	D9L	156
Unknown	C1L	224	C19L	231	D19L	214	D14L	214
Unknown	C16L	181	D5L	153	—	—	D1L	153
Unknown	N2L	175	Q2L	175	P2L	177	P2L	177

VARV-IND: VARV strain India,1967, MPXV-ZAI: MPXV strain Zaire-I-96, CPXV-GRI: CPXV strain GRI-90, VAC-COP: VACV strain Copenhagen. ORF: open reading frame; aa: protein size in number of amino acid residues.