Table of Contents Author Guidelines Submit a Manuscript
Advances in Virology
Volume 2012, Article ID 532723, 10 pages
Review Article

Budding of Enveloped Viruses: Interferon-Induced ISG15—Antivirus Mechanisms Targeting the Release Process

Department of Microbiology and Immunology, Northwestern University Feinberg School of Medicine, Ward 4-065, 303 E. Chicago Avenue, Chicago, IL 60611, USA

Received 23 January 2012; Accepted 12 March 2012

Academic Editor: Trudy Morrison

Copyright © 2012 Eun Joo Seo and Jonathan Leis. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Pathogenic strains of viruses that infect humans are encapsulated in membranes derived from the host cell in which they infect. After replication, these viruses are released by a budding process that requires cell/viral membrane scission. As such, this represents a natural target for innate immunity mechanisms to interdict enveloped virus spread and recent advances in this field will be the subject of this paper.