In Silico and In Vitro Comparison of HIV-1 Subtypes B and CRF02_AG Integrases Susceptibility to Integrase Strand Transfer Inhibitors

Figure 2

Purification of recombinant HIV-1 INs from B and CRF02_AG subtypes and comparison of their activities. (a) Purification products N₁, N₂, N₃ and N₄ of recombinant HIV-1 INs from B and CRF02_AG subtypes. (b)–(d) Comparison of DNA binding, 3′-processing and strand transfer activities, respectively, of the HIV-1 IN from B and CRF02_AG as a function of IN concentration.

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