Structural Differences Observed in Arboviruses of the Alphavirus and Flavivirus Genera
Figure 10
Conformational changes in Sindbis virus after exposure to various pH conditions. The three-dimensional structures of Sindbis virus surface at 28 Å resolution viewed along icosahedral threefold axes ((a)–(c)). Central cross section of Sindbis virus ((d)–(f)). Three-dimensional structure of the Sindbis virus capsid (inside the membrane bilayer) viewed along the icosahedral threefold axes ((g)–(i)). The reconstructions are colored according to a range of radii (key displayed) at different pH conditions ((a), (d), and (g)). Sindbis virus at pH 7.2. ((b), (e), and (h)) Sindbis virus at pH 5.3. ((c), (f), and (i)) Sindbis virus exposed to pH 5.3 (5 min) and returned to pH 7.2. Arrows: (b) protrusion at the fivefold axis; (c) fissure at twofold axis; ((d), (e), and (f)) fivefold axis; (g) region of cross-section occupied by the membrane bilayer. Paredes et al. 2004 [122].
