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Advances in Virology
Volume 2016, Article ID 1016840, 14 pages
http://dx.doi.org/10.1155/2016/1016840
Review Article

Vitamin D-Regulated MicroRNAs: Are They Protective Factors against Dengue Virus Infection?

Grupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia (UdeA), Calle 70 No. 52-51, Medellín, Colombia

Received 22 December 2015; Revised 7 April 2016; Accepted 20 April 2016

Academic Editor: Subhash C. Verma

Copyright © 2016 John F. Arboleda and Silvio Urcuqui-Inchima. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. B. A. Beutler, “TLRs and innate immunity,” Blood, vol. 113, no. 7, pp. 1399–1407, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. A. Dalpke, K. Heeg, H. Bartz, and A. Baetz, “Regulation of innate immunity by suppressor of cytokine signaling (SOCS) proteins,” Immunobiology, vol. 213, no. 3-4, pp. 225–235, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. B. E. E. Martina, “Dengue pathogenesis: a disease driven by the host response,” Science Progress, vol. 97, part 3, pp. 197–214, 2014. View at Google Scholar
  4. T. Pang, M. J. Cardosa, and M. G. Guzman, “Of cascades and perfect storms: the immunopathogenesis of dengue haemorrhagic fever-dengue shock syndrome (DHF/DSS),” Immunology and Cell Biology, vol. 85, no. 1, pp. 43–45, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. E. van Etten, K. Stoffels, C. Gysemans, C. Mathieu, and L. Overbergh, “Regulation of vitamin D homeostasis: implications for the immune system,” Nutrition Reviews, vol. 66, no. 2, pp. S125–S134, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. X. Guillot, L. Semerano, N. Saidenberg-Kermanac'h, G. Falgarone, and M.-C. Boissier, “Vitamin D and inflammation,” Joint Bone Spine, vol. 77, no. 6, pp. 552–557, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. V. V. Costa, C. T. Fagundes, D. G. Souza, and D. M. M. Teixeira, “Inflammatory and innate immune responses in dengue infection: protection versus disease induction,” The American Journal of Pathology, vol. 182, no. 6, pp. 1950–1961, 2013. View at Publisher · View at Google Scholar
  8. Z. R. Brenner, A. B. Miller, L. C. Ayers, and A. Roberts, “The role of vitamin D in critical illness,” Critical Care Nursing Clinics of North America, vol. 24, no. 4, pp. 527–540, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Ahmed, J. L. Finkelstein, A. M. Stewart et al., “Micronutrients and dengue,” The American Journal of Tropical Medicine and Hygiene, vol. 91, no. 5, pp. 1049–1056, 2014. View at Publisher · View at Google Scholar · View at Scopus
  10. K. Alagarasu, T. Honap, A. P. Mulay, R. V. Bachal, P. S. Shah, and D. Cecilia, “Association of vitamin D receptor gene polymorphisms with clinical outcomes of dengue virus infection,” Human Immunology, vol. 73, no. 11, pp. 1194–1199, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. E. Sánchez-Valdéz, M. Delgado-Aradillas, J. A. Torres-Martínez, and J. M. Torres-Benítez, “Clinical response in patients with dengue fever to oral calcium plus vitamin D administration: study of 5 cases,” Proceedings of the Western Pharmacology Society, vol. 52, pp. 14–17, 2009. View at Google Scholar · View at Scopus
  12. H. Loke, D. Bethell, C. X. T. Phuong et al., “Susceptibility to dengue hemorrhagic fever in vietnam: evidence of an association with variation in the vitamin D receptor and FCγ receptor IIA genes,” The American Journal of Tropical Medicine and Hygiene, vol. 67, no. 1, pp. 102–106, 2002. View at Google Scholar · View at Scopus
  13. J. A. Beard, A. Bearden, and R. Striker, “Vitamin D and the anti-viral state,” Journal of Clinical Virology, vol. 50, no. 3, pp. 194–200, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. E. Borella, G. Nesher, E. Israeli, and Y. Shoenfeld, “Vitamin D: a new anti-infective agent?” Annals of the New York Academy of Sciences, vol. 1317, no. 1, pp. 76–83, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. A. A. Giangreco and L. Nonn, “The sum of many small changes: microRNAs are specifically and potentially globally altered by vitamin D3 metabolites,” The Journal of Steroid Biochemistry and Molecular Biology, vol. 136, no. 1, pp. 86–93, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. L. He and G. J. Hannon, “MicroRNAs: small RNAs with a big role in gene regulation,” Nature Reviews. Genetics, vol. 5, no. 7, pp. 522–531, 2004. View at Publisher · View at Google Scholar
  17. J. Han, Y. Lee, K.-H. Yeom, Y.-K. Kim, H. Jin, and V. N. Kim, “The Drosha-DGCR8 complex in primary microRNA processing,” Genes & Development, vol. 18, no. 24, pp. 3016–3027, 2004. View at Publisher · View at Google Scholar · View at Scopus
  18. L.-A. MacFarlane and P. R. Murphy, “MicroRNA: biogenesis, function and role in cancer,” Current Genomics, vol. 11, no. 7, pp. 537–561, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. Y. Zhang, D. Y. M. Leung, B. N. Richers et al., “Vitamin D inhibits monocyte/macrophage proinflammatory cytokine production by targeting MAPK phosphatase-1,” The Journal of Immunology, vol. 188, no. 5, pp. 2127–2135, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. Y. Chen, W. Liu, T. Sun et al., “1,25-dihydroxyvitamin D promotes negative feedback regulation of TLR signaling via targeting microRNA-155-SOCS1 in macrophages,” The Journal of Immunology, vol. 190, no. 7, pp. 3687–3695, 2013. View at Publisher · View at Google Scholar · View at Scopus
  21. E. Sonkoly, M. Ståhle, and A. Pivarcsi, “MicroRNAs and immunity: novel players in the regulation of normal immune function and inflammation,” Seminars in Cancer Biology, vol. 18, no. 2, pp. 131–140, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. S. R. S. Hadinegoro, “The revised WHO dengue case classification: does the system need to be modified?” Paediatrics and International Child Health, vol. 32, supplement 1, pp. 33–38, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. M. S. Mustafa, V. Rasotgi, S. Jain, and V. Gupta, “Discovery of fifth serotype of dengue virus (DENV-5): a new public health dilemma in dengue control,” Medical Journal Armed Forces India, vol. 71, no. 1, pp. 67–70, 2015. View at Publisher · View at Google Scholar · View at Scopus
  24. B.-A. Coller, A. D. T. Barrett, S. J. Thomas, J. Whitehorn, and C. P. Simmons, “The pathogenesis of dengue,” Vaccine, vol. 29, no. 42, pp. 7221–7228, 2011. View at Publisher · View at Google Scholar
  25. A. Wilder-Smith, E.-E. Ooi, S. G. Vasudevan, and D. J. Gubler, “Update on dengue: epidemiology, virus evolution, antiviral drugs, and vaccine development,” Current Infectious Disease Reports, vol. 12, no. 3, pp. 157–164, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. M. E. Wilson and L. H. Chen, “Dengue: update on epidemiology,” Current Infectious Disease Reports, vol. 17, no. 1, p. 457, 2015. View at Publisher · View at Google Scholar
  27. S. Bhatt, P. W. Gething, O. J. Brady et al., “The global distribution and burden of dengue,” Nature, vol. 496, no. 7446, pp. 504–507, 2013. View at Publisher · View at Google Scholar · View at Scopus
  28. O. J. Brady, P. W. Gething, S. Bhatt et al., “Refining the global spatial limits of dengue virus transmission by evidence-based consensus,” PLoS Neglected Tropical Diseases, vol. 6, no. 8, Article ID e1760, 2012. View at Publisher · View at Google Scholar · View at Scopus
  29. S. B. Halstead, “Controversies in dengue pathogenesis,” Paediatrics and International Child Health, vol. 32, no. 1, pp. 5–9, 2012. View at Publisher · View at Google Scholar · View at Scopus
  30. S. Yacoub, J. Mongkolsapaya, and G. Screaton, “The pathogenesis of dengue,” Current Opinion in Infectious Diseases, vol. 26, no. 3, pp. 284–289, 2013. View at Publisher · View at Google Scholar
  31. B. E. E. Martina, P. Koraka, and A. D. M. E. Osterhaus, “Dengue virus pathogenesis: an integrated view,” Clinical Microbiology Reviews, vol. 22, no. 4, pp. 564–581, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. J. Flipse, J. Wilschut, and J. M. Smit, “Molecular mechanisms involved in antibody-dependent enhancement of dengue virus infection in humans,” Traffic, vol. 14, no. 1, pp. 25–35, 2013. View at Publisher · View at Google Scholar · View at Scopus
  33. T. Kawai and S. Akira, “The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors,” Nature Immunology, vol. 11, no. 5, pp. 373–384, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. S.-J. L. Wu, G. Grouard-Vogel, W. Sun et al., “Human skin Langerhans cells are targets of dengue virus infection,” Nature Medicine, vol. 6, no. 7, pp. 816–820, 2000. View at Publisher · View at Google Scholar · View at Scopus
  35. Z. Kou, M. Quinn, H. Chen et al., “Monocytes, but not T or B cells, are the principal target cells for dengue virus (DV) infection among human peripheral blood mononuclear cells,” Journal of Medical Virology, vol. 80, no. 1, pp. 134–146, 2008. View at Publisher · View at Google Scholar · View at Scopus
  36. E. G. Acosta, A. Kumar, and R. Bartenschlager, “Revisiting dengue virus-host cell interaction: new insights into molecular and cellular virology,” Advances in Virus Research, vol. 88, pp. 1–109, 2014. View at Publisher · View at Google Scholar · View at Scopus
  37. S. Urcuqui-Inchima, C. Patiño, S. Torres, A.-L. Haenni, and F. J. Díaz, “Recent developments in understanding dengue virus replication,” Advances in Virus Research, vol. 77, pp. 1–39, 2010. View at Publisher · View at Google Scholar · View at Scopus
  38. D. G. Nielsen, “The relationship of interacting immunological components in dengue pathogenesis,” Virology Journal, vol. 6, article 211, 2009. View at Publisher · View at Google Scholar · View at Scopus
  39. Z. Liang, S. Wu, Y. Li et al., “Activation of toll-like receptor 3 impairs the dengue virus serotype 2 replication through induction of IFN-β in cultured hepatoma cells,” PLoS ONE, vol. 6, no. 8, Article ID e23346, 2011. View at Publisher · View at Google Scholar · View at Scopus
  40. A. M. A. Nasirudeen, H. H. Wong, P. Thien, S. Xu, K.-P. Lam, and D. X. Liu, “RIG-I, MDA5 and TLR3 synergistically play an important role in restriction of dengue virus infection,” PLoS Neglected Tropical Diseases, vol. 5, no. 1, article e926, 2011. View at Publisher · View at Google Scholar · View at Scopus
  41. S. Jensen and A. R. Thomsen, “Sensing of rna viruses: a review of innate immune receptors involved in recognizing RNA virus invasion,” Journal of Virology, vol. 86, no. 6, pp. 2900–2910, 2012. View at Publisher · View at Google Scholar · View at Scopus
  42. J. Morrison, S. Aguirre, and A. Fernandez-Sesma, “Innate immunity evasion by dengue virus,” Viruses, vol. 4, no. 3, pp. 397–413, 2012. View at Publisher · View at Google Scholar · View at Scopus
  43. A. Huerta-Zepeda, C. Cabello-Gutiérrez, J. Cime-Castillo et al., “Crosstalk between coagulation and inflammation during Dengue virus infection,” Thrombosis and Haemostasis, vol. 99, no. 5, pp. 936–943, 2008. View at Publisher · View at Google Scholar · View at Scopus
  44. M. Yu and S. J. Levine, “Toll-like receptor 3, RIG-I-like receptors and the NLRP3 inflammasome: key modulators of innate immune responses to double-stranded RNA viruses,” Cytokine & Growth Factor Reviews, vol. 22, no. 2, pp. 63–72, 2011. View at Publisher · View at Google Scholar · View at Scopus
  45. M. Yoneyama, M. Kikuchi, K. Matsumoto et al., “Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity,” Journal of Immunology, vol. 175, no. 5, pp. 2851–2858, 2005. View at Publisher · View at Google Scholar · View at Scopus
  46. B. E. E. B. Martina, P. Koraka, and A. D. M. E. Osterhaus, “Dengue virus pathogenesis: an integrated view,” Clinical Microbiology Reviews, vol. 22, no. 4, pp. 564–581, 2009. View at Publisher · View at Google Scholar · View at Scopus
  47. S. M. Stamatovic, R. F. Keep, S. L. Kunkel, and A. V. Andjelkovic, “Potential role of MCP-1 in endothelial cell tight junction ‘opening’: signaling via Rho and Rho kinase,” Journal of Cell Science, vol. 116, no. 22, pp. 4615–4628, 2003. View at Publisher · View at Google Scholar · View at Scopus
  48. Y.-R. Lee, M.-T. Liu, H.-Y. Lei et al., “MCP1, a highly expressed chemokine in dengue haemorrhagic fever/dengue shock syndrome patients, may cause permeability change, possibly through reduced tight junctions of vascular endothelium cells,” The Journal of General Virology, vol. 87, no. 12, pp. 3623–3630, 2006. View at Publisher · View at Google Scholar · View at Scopus
  49. J. F. Kelley, P. H. Kaufusi, and V. R. Nerurkar, “Dengue hemorrhagic fever-associated immunomediators induced via maturation of dengue virus nonstructural 4B protein in monocytes modulate endothelial cell adhesion molecules and human microvascular endothelial cells permeability,” Virology, vol. 422, no. 2, pp. 326–337, 2012. View at Publisher · View at Google Scholar · View at Scopus
  50. Y. Huang, H. Lei, H. Liu, Y. Lin, C. Liu, and T. Yeh, “Dengue virus infects human endothelial cells and induces IL-6 and IL-8 production,” The American Journal of Tropical Medicine and Hygiene, vol. 63, no. 1, pp. 71–75, 2000. View at Google Scholar
  51. H. Puerta-Guardo, A. Raya-Sandino, L. González-Mariscal et al., “The cytokine response of U937-derived macrophages infected through antibody-dependent enhancement of dengue virus disrupts cell apical-junction complexes and increases vascular permeability,” Journal of Virology, vol. 87, no. 13, pp. 7486–7501, 2013. View at Publisher · View at Google Scholar · View at Scopus
  52. D. Talavera, A. M. Castillo, M. C. Dominguez, A. Escobar Gutierrez, and I. Meza, “IL8 release, tight junction and cytoskeleton dynamic reorganization conducive to permeability increase are induced by dengue virus infection of microvascular endothelial monolayers,” The Journal of General Virology, vol. 85, no. 7, pp. 1801–1813, 2004. View at Publisher · View at Google Scholar · View at Scopus
  53. T.-T. Tsai, Y.-J. Chuang, Y.-S. Lin, S.-W. Wan, C.-L. Chen, and C.-F. Lin, “An emerging role for the anti-inflammatory cytokine interleukin-10 in dengue virus infection,” Journal of Biomedical Science, vol. 20, no. 1, article 40, 2013. View at Publisher · View at Google Scholar · View at Scopus
  54. P. Liu, M. Woda, F. A. Ennis, and D. H. Libraty, “Dengue virus infection differentially regulates endothelial barrier function over time through type I interferon effects,” Journal of Infectious Diseases, vol. 200, no. 2, pp. 191–201, 2009. View at Publisher · View at Google Scholar · View at Scopus
  55. C. Lee, O. Buznyk, L. Kuffova et al., “Cathelicidin LL-37 and HSV-1 corneal infection: peptide versus gene therapy,” Translational Vision Science & Technology, vol. 3, no. 3, article 4, 2014. View at Publisher · View at Google Scholar
  56. S. Tripathi, G. Wang, M. White, L. Qi, J. Taubenberger, and K. L. Hartshorn, “Antiviral activity of the human cathelicidin, LL-37, and derived peptides on seasonal and pandemic influenza A viruses,” PLoS ONE, vol. 10, no. 4, Article ID e0124706, 2015. View at Publisher · View at Google Scholar · View at Scopus
  57. P. Bergman, L. Walter-Jallow, K. Broliden, B. Agerberth, and J. Söderlund, “The antimicrobial peptide LL-37 inhibits HIV-1 replication,” Current HIV Research, vol. 5, no. 4, pp. 410–415, 2007. View at Publisher · View at Google Scholar · View at Scopus
  58. V. Tangpricha, S. E. Judd, T. R. Ziegler et al., “LL-37 concentrations and the relationship to vitamin D, immune status, and inflammation in HIV-infected children and young adults,” AIDS Research and Human Retroviruses, vol. 30, no. 7, pp. 670–676, 2014. View at Publisher · View at Google Scholar · View at Scopus
  59. A. Schögler, R. J. Muster, E. Kieninger et al., “Vitamin D represses rhinovirus replication in cystic fibrosis cells by inducing LL-37,” The European Respiratory Journal, vol. 47, no. 2, pp. 520–530, 2016. View at Publisher · View at Google Scholar
  60. W. Aguilar-Jiménez, W. Zapata, A. Caruz, and M. T. Rugeles, “High transcript levels of vitamin D receptor are correlated with higher mRNA expression of human beta defensins and IL-10 in mucosa of HIV-1-exposed seronegative individuals,” PLoS ONE, vol. 8, no. 12, Article ID e82717, 2013. View at Publisher · View at Google Scholar · View at Scopus
  61. M. Gal-Tanamy, L. Bachmetov, A. Ravid et al., “Vitamin D: an innate antiviral agent suppressing hepatitis C virus in human hepatocytes,” Hepatology, vol. 54, no. 5, pp. 1570–1579, 2011. View at Publisher · View at Google Scholar · View at Scopus
  62. H. Farnik, J. Bojunga, A. Berger et al., “Low vitamin D serum concentration is associated with high levels of hepatitis B virus replication in chronically infected patients,” Hepatology, vol. 58, no. 4, pp. 1270–1276, 2013. View at Publisher · View at Google Scholar · View at Scopus
  63. S. Yokoyama, S. Takahashi, Y. Kawakami et al., “Effect of vitamin D supplementation on pegylated interferon/ribavirin therapy for chronic hepatitis C genotype 1b: a randomized controlled trial,” Journal of Viral Hepatitis, vol. 21, no. 5, pp. 348–356, 2014. View at Publisher · View at Google Scholar · View at Scopus
  64. B. Terrier, F. Carrat, G. Geri et al., “Low 25-OH vitamin D serum levels correlate with severe fibrosis in HIV-HCV co-infected patients with chronic hepatitis,” Journal of Hepatology, vol. 55, no. 4, pp. 756–761, 2011. View at Publisher · View at Google Scholar · View at Scopus
  65. G. R. Campbell and S. A. Spector, “Autophagy induction by vitamin D inhibits both Mycobacterium tuberculosis and human immunodeficiency virus type 1,” Autophagy, vol. 8, no. 10, pp. 1523–1525, 2012. View at Publisher · View at Google Scholar · View at Scopus
  66. G. R. Campbell and S. A. Spector, “Hormonally active vitamin D3 (1α,25-dihydroxycholecalciferol) triggers autophagy in human macrophages that inhibits HIV-1 infection,” The Journal of Biological Chemistry, vol. 286, no. 21, pp. 18890–18902, 2011. View at Publisher · View at Google Scholar · View at Scopus
  67. H. Guan, C. Liu, Z. Chen et al., “1,25-dihydroxyvitamin D3 up-regulates expression of hsa-let-7a-2 through the interaction of VDR/VDRE in human lung cancer A549 cells,” Gene, vol. 522, no. 2, pp. 142–146, 2013. View at Publisher · View at Google Scholar · View at Scopus
  68. M. Escalera-Cueto, I. Medina-Martínez, R. M. Del Angel, J. Berumen-Campos, A. L. Gutiérrez-Escolano, and M. Yocupicio-Monroy, “Let-7c overexpression inhibits dengue virus replication in human hepatoma Huh-7 cells,” Virus Research, vol. 196, pp. 105–112, 2015. View at Publisher · View at Google Scholar · View at Scopus
  69. N. Fitch, A. B. Becker, and K. T. HayGlass, “Vitamin D [1,25(OH)2D3] differentially regulates human innate cytokine responses to bacterial versus viral pattern recognition receptor stimuli,” The Journal of Immunology, vol. 196, no. 7, pp. 2965–2972, 2016. View at Publisher · View at Google Scholar
  70. E.-A. Ye and J. J. Steinle, “miR-146a attenuates inflammatory pathways mediated by TLR4/NF-κB and TNFα to protect primary human retinal microvascular endothelial cells grown in high glucose,” Mediators of Inflammation, vol. 2016, Article ID 3958453, 9 pages, 2016. View at Publisher · View at Google Scholar
  71. K. Sadeghi, B. Wessner, U. Laggner et al., “Vitamin D3 down-regulates monocyte TLR expression and triggers hyporesponsiveness to pathogen-associated molecular patterns,” European Journal of Immunology, vol. 36, no. 2, pp. 361–370, 2006. View at Publisher · View at Google Scholar · View at Scopus
  72. H. Puerta-Guardo, F. Medina, S. I. De la Cruz Hernández, V. H. Rosales, J. E. Ludert, and R. M. del Angel, “The 1α,25-dihydroxy-vitamin D3 reduces dengue virus infection in human myelomonocyte (U937) and hepatic (Huh-7) cell lines and cytokine production in the infected monocytes,” Antiviral Research, vol. 94, no. 1, pp. 57–61, 2012. View at Publisher · View at Google Scholar
  73. Y. Qi, Y. Li, L. Zhang, and J. Huang, “MicroRNA expression profiling and bioinformatic analysis of dengue virus-infected peripheral blood mononuclear cells,” Molecular Medicine Reports, vol. 7, no. 3, pp. 791–798, 2013. View at Publisher · View at Google Scholar · View at Scopus
  74. V. Gonzalez-Pardo, N. D'Elia, A. Verstuyf, R. Boland, and A. Russo de Boland, “NFκB pathway is down-regulated by 1α,25(OH)2-vitamin D3 in endothelial cells transformed by Kaposi sarcoma-associated herpes virus G protein coupled receptor,” Steroids, vol. 77, no. 11, pp. 1025–1032, 2012. View at Publisher · View at Google Scholar · View at Scopus
  75. D. Bhaumik, G. K. Scott, S. Schokrpur, C. K. Patil, J. Campisi, and C. C. Benz, “Expression of microRNA-146 suppresses NF-κB activity with reduction of metastatic potential in breast cancer cells,” Oncogene, vol. 27, no. 42, pp. 5643–5647, 2008. View at Publisher · View at Google Scholar · View at Scopus
  76. Y. Chen, J. Zhang, X. Ge, J. Du, D. K. Deb, and Y. C. Li, “Vitamin D receptor inhibits nuclear factor κb activation by interacting with IκB kinase β protein,” The Journal of Biological Chemistry, vol. 288, no. 27, pp. 19450–19458, 2013. View at Publisher · View at Google Scholar · View at Scopus
  77. L. J. Dickie, L. D. Church, L. R. Coulthard, R. J. Mathews, P. Emery, and M. F. McDermott, “Vitamin D3 down-regulates intracellular Toll-like receptor 9 expression and Toll-like receptor 9-induced IL-6 production in human monocytes,” Rheumatology, vol. 49, no. 8, pp. 1466–1471, 2010. View at Publisher · View at Google Scholar
  78. H. Yan, Y. Zhou, Y. Liu, Y. Deng, S. Puthiyakunnon, and X. Chen, “miR-252 of the Asian tiger mosquito Aedes albopictus regulates dengue virus replication by suppressing the expression of the dengue virus envelope protein,” Journal of Medical Virology, vol. 86, no. 8, pp. 1428–1436, 2014. View at Publisher · View at Google Scholar · View at Scopus
  79. X. Zhu, Z. He, Y. Hu et al., “MicroRNA-30e suppresses dengue virus replication by promoting NF-κB-dependent IFN production,” PLoS Neglected Tropical Diseases, vol. 8, no. 8, p. e3088, 2014. View at Publisher · View at Google Scholar
  80. R.-F. Chen, K. D. Yang, I.-K. Lee et al., “Augmented miR-150 expression associated with depressed SOCS1 expression involved in dengue haemorrhagic fever,” The Journal of Infection, vol. 69, no. 4, pp. 366–374, 2014. View at Publisher · View at Google Scholar · View at Scopus
  81. T.-C. Lee, Y.-L. Lin, J.-T. Liao et al., “Utilizing liver-specific microRNA-122 to modulate replication of dengue virus replicon,” Biochemical and Biophysical Research Communications, vol. 396, no. 3, pp. 596–601, 2010. View at Publisher · View at Google Scholar · View at Scopus
  82. A. M. Pham, R. A. Langlois, and B. R. tenOever, “Replication in cells of hematopoietic origin is necessary for dengue virus dissemination,” PLoS Pathogens, vol. 8, no. 1, Article ID e1002465, 2012. View at Publisher · View at Google Scholar · View at Scopus
  83. P. L. Boutz, G. Chawla, P. Stoilov, and D. L. Black, “MicroRNAs regulate the expression of the alternative splicing factor nPTB during muscle development,” Genes & Development, vol. 21, no. 1, pp. 71–84, 2007. View at Publisher · View at Google Scholar · View at Scopus
  84. J. A. Castillo, J. C. Castrillón, M. Diosa-Toro et al., “Complex interaction between dengue virus replication and expression of miRNA-133a,” BMC Infectious Diseases, vol. 16, no. 1, article 29, 2015. View at Publisher · View at Google Scholar
  85. W. Wen, Z. He, Q. Jing et al., “Cellular microRNA-miR-548g-3p modulates the replication of dengue virus,” The Journal of Infection, vol. 70, no. 6, pp. 631–640, 2015. View at Publisher · View at Google Scholar
  86. N. Wu, N. Gao, D. Fan, J. Wei, J. Zhang, and J. An, “miR-223 inhibits dengue virus replication by negatively regulating the microtubule-destabilizing protein STMN1 in EAhy926 cells,” Microbes and Infection, vol. 16, no. 11, pp. 911–922, 2014. View at Publisher · View at Google Scholar
  87. A. K. I. Falconar, “The dengue virus nonstructural-1 protein (NS1) generates antibodies to common epitopes on human blood clotting, integrin/adhesin proteins and binds to human endothelial cells: Potential implications in haemorrhagic fever pathogenesis,” Archives of Virology, vol. 142, no. 5, pp. 897–916, 1997. View at Publisher · View at Google Scholar · View at Scopus
  88. A. L. Rothman, “Immunity to dengue virus: a tale of original antigenic sin and tropical cytokine storms,” Nature Reviews Immunology, vol. 11, no. 8, pp. 532–543, 2011. View at Publisher · View at Google Scholar · View at Scopus
  89. T.-M. Yeh, S.-H. Liu, K.-C. Lin et al., “Dengue virus enhances thrombomodulin and ICAM-1 expression through the macrophage migration inhibitory factor induction of the MAPK and PI3K signaling pathways,” PLoS ONE, vol. 8, no. 1, Article ID e55018, 2013. View at Publisher · View at Google Scholar · View at Scopus
  90. K. Ellencrona, A. Syed, and M. Johansson, “Flavivirus NS5 associates with host-cell proteins zonula occludens-1 (ZO-1) and regulating synaptic membrane exocytosis-2 (RIMS2) via an internal PDZ binding mechanism,” Biological Chemistry, vol. 390, no. 4, pp. 319–323, 2009. View at Publisher · View at Google Scholar · View at Scopus
  91. M. D. de Kruif, T. E. Setiati, A. T. A. Mairuhu et al., “Differential gene expression changes in children with severe dengue virus infections,” PLoS Neglected Tropical Diseases, vol. 2, no. 4, article e215, 2008. View at Publisher · View at Google Scholar · View at Scopus
  92. S. Ubol, P. Masrinoul, J. Chaijaruwanich, S. Kalayanarooj, T. Charoensirisuthikul, and J. Kasisith, “Differences in global gene expression in peripheral blood mononuclear cells indicate a significant role of the innate responses in progression of dengue fever but not dengue hemorrhagic fever,” The Journal of Infectious Diseases, vol. 197, no. 10, pp. 1459–1467, 2008. View at Publisher · View at Google Scholar · View at Scopus
  93. J. Chen, M. M.-L. Ng, and J. J. H. Chu, “Activation of TLR2 and TLR6 by dengue NS1 protein and its implications in the immunopathogenesis of dengue virus infection,” PLoS Pathogens, vol. 11, no. 7, Article ID e1005053, 2015. View at Publisher · View at Google Scholar · View at Scopus
  94. P. R. Beatty, H. Puerta-Guardo, S. S. Killingbeck, D. R. Glasner, K. Hopkins, and E. Harris, “Dengue virus NS1 triggers endothelial permeability and vascular leak that is prevented by NS1 vaccination,” Science Translational Medicine, vol. 7, no. 304, Article ID 304ra141, 2015. View at Publisher · View at Google Scholar · View at Scopus
  95. S. Torres, J. C. Hernández, D. Giraldo et al., “Differential expression of Toll-like receptors in dendritic cells of patients with dengue during early and late acute phases of the disease,” PLoS Neglected Tropical Diseases, vol. 7, no. 2, Article ID e2060, 2013. View at Publisher · View at Google Scholar · View at Scopus
  96. S. Pagni and A. Fernandez-Sesma, “Evasion of the human innate immune system by dengue virus,” Immunologic Research, vol. 54, no. 1–3, pp. 152–159, 2012. View at Publisher · View at Google Scholar · View at Scopus
  97. J. L. Muñoz-Jordán, M. Laurent-Rolle, J. Ashour et al., “Inhibition of alpha/beta interferon signaling by the NS4B protein of flaviviruses,” Journal of Virology, vol. 79, no. 13, pp. 8004–8013, 2005. View at Publisher · View at Google Scholar · View at Scopus
  98. J. L. Miller, B. J. M. deWet, L. Martinez-Pomares et al., “The mannose receptor mediates dengue virus infection of macrophages,” PLoS Pathogens, vol. 4, no. 2, article e17, 2008. View at Publisher · View at Google Scholar · View at Scopus
  99. M.-F. Wu, S.-T. Chen, A.-H. Yang et al., “CLEC5A is critical for dengue virus-induced inflammasome activation in human macrophages,” Blood, vol. 121, no. 1, pp. 95–106, 2013. View at Publisher · View at Google Scholar · View at Scopus
  100. E. Schaeffer, V. Flacher, V. Papageorgiou et al., “Dermal CD14+ dendritic cell and macrophage infection by dengue virus is stimulated by interleukin-4,” Journal of Investigative Dermatology, vol. 135, no. 7, pp. 1743–1751, 2015. View at Publisher · View at Google Scholar
  101. M.-F. Wu, S.-T. Chen, and S.-L. Hsieh, “Distinct regulation of dengue virus-induced inflammasome activation in human macrophage subsets,” Journal of Biomedical Science, vol. 20, no. 1, article 36, 2013. View at Publisher · View at Google Scholar · View at Scopus
  102. T. Dong, E. Moran, N. Vinh Chau et al., “High pro-inflammatory cytokine secretion and loss of high avidity cross-reactive cytotoxic T-cells during the course of secondary dengue virus infection,” PLoS ONE, vol. 2, no. 12, Article ID e1192, 2007. View at Publisher · View at Google Scholar · View at Scopus
  103. F. Baeke, T. Takiishi, H. Korf, C. Gysemans, and C. Mathieu, “Vitamin D: modulator of the immune system,” Current Opinion in Pharmacology, vol. 10, no. 4, pp. 482–496, 2010. View at Publisher · View at Google Scholar · View at Scopus
  104. M. Hewison, “Vitamin D and the intracrinology of innate immunity,” Molecular and Cellular Endocrinology, vol. 321, no. 2, pp. 103–111, 2010. View at Publisher · View at Google Scholar · View at Scopus
  105. C. L. Greiller and A. R. Martineau, “Modulation of the immune response to respiratory viruses by vitamin D,” Nutrients, vol. 7, no. 6, pp. 4240–4270, 2015. View at Publisher · View at Google Scholar · View at Scopus
  106. A. K. Coussens, A. R. Martineau, and R. J. Wilkinson, “Anti-inflammatory and antimicrobial actions of vitamin D in combating TB/HIV,” Scientifica, vol. 2014, Article ID 903680, 13 pages, 2014. View at Publisher · View at Google Scholar
  107. S. Christakos, D. V. Ajibade, P. Dhawan, A. J. Fechner, and L. J. Mady, “Vitamin D: metabolism,” Endocrinology and Metabolism Clinics of North America, vol. 39, no. 2, pp. 243–253, 2010. View at Publisher · View at Google Scholar · View at Scopus
  108. S. Christakos, P. Dhawan, Q. Shen, X. Peng, B. Benn, and Y. Zhong, “New insights into the mechanisms involved in the pleiotropic actions of 1,25dihydroxyvitamin D3,” Annals of the New York Academy of Sciences, vol. 1068, no. 1, pp. 194–203, 2006. View at Publisher · View at Google Scholar · View at Scopus
  109. A. S. Dusso and A. J. Brown, “Mechanism of vitamin D action and its regulation,” American Journal of Kidney Diseases, vol. 32, no. 2, supplement 2, pp. S13–S24, 1998. View at Publisher · View at Google Scholar · View at Scopus
  110. J. S. Adams and M. Hewison, “Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity,” Nature Clinical Practice Endocrinology and Metabolism, vol. 4, no. 2, pp. 80–90, 2008. View at Publisher · View at Google Scholar · View at Scopus
  111. R. F. Chun, J. S. Adams, and M. Hewison, “Back to the future: a new look at ‘old’ vitamin D,” The Journal of Endocrinology, vol. 198, no. 2, pp. 261–269, 2008. View at Publisher · View at Google Scholar · View at Scopus
  112. M. Hewison, “Vitamin D and the immune system: new perspectives on an old theme,” Endocrinology and Metabolism Clinics of North America, vol. 39, no. 2, pp. 365–379, 2010. View at Publisher · View at Google Scholar · View at Scopus
  113. M. Hewison, “Vitamin D and innate immunity,” Current Opinion in Investigational Drugs, vol. 9, no. 5, pp. 485–490, 2008. View at Google Scholar
  114. M. Hewison, “Vitamin D and innate and adaptive immunity,” Vitamins and Hormones, vol. 86, pp. 23–62, 2011. View at Publisher · View at Google Scholar · View at Scopus
  115. M. Etminani-Esfahani, H. Khalili, N. Soleimani et al., “Serum vitamin D concentration and potential risk factors for its deficiency in HIV positive individuals,” Current HIV Research, vol. 10, no. 2, pp. 165–170, 2012. View at Publisher · View at Google Scholar · View at Scopus
  116. G. R. Campbell and S. A. Spector, “Vitamin D inhibits human immunodeficiency virus type 1 and Mycobacterium tuberculosis infection in macrophages through the induction of autophagy,” PLoS Pathogens, vol. 8, no. 5, Article ID e1002689, 2012. View at Publisher · View at Google Scholar · View at Scopus
  117. P. T. Liu, S. Stenger, H. Li et al., “Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response,” Science, vol. 311, no. 5768, pp. 1770–1773, 2006. View at Publisher · View at Google Scholar · View at Scopus
  118. Y. Zhao, B. Yu, X. Mao et al., “Effect of 25-hydroxyvitamin D3 on rotavirus replication and gene expressions of RIG-I signalling molecule in porcine rotavirus-infected IPEC-J2 cells,” Archives of Animal Nutrition, vol. 69, no. 3, pp. 227–235, 2015. View at Publisher · View at Google Scholar
  119. M. Reinholz and J. Schauber, “Vitamin D and innate immunity of the skin,” Deutsche Medizinische Wochenschrift, vol. 137, no. 46, pp. 2385–2389, 2012. View at Publisher · View at Google Scholar · View at Scopus
  120. I. Szymczak and R. Pawliczak, “The active metabolite of vitamin D3 as a potential immunomodulator,” Scandinavian Journal of Immunology, vol. 83, no. 2, pp. 83–91, 2016. View at Publisher · View at Google Scholar
  121. H. A. Bischoff-Ferrari, B. Dawson-Hughes, A. Platz et al., “Effect of high-dosage cholecalciferol and extended physiotherapy on complications after hip fracture: a randomized controlled trial,” Archives of Internal Medicine, vol. 170, no. 9, pp. 813–820, 2010. View at Publisher · View at Google Scholar · View at Scopus
  122. P. O. Lang, N. Samaras, D. Samaras, and R. Aspinall, “How important is vitamin D in preventing infections?” Osteoporosis International, vol. 24, no. 5, pp. 1537–1553, 2013. View at Publisher · View at Google Scholar · View at Scopus
  123. C. S. Maxwell, E. T. Carbone, and R. J. Wood, “Better newborn vitamin D status lowers RSV-associated bronchiolitis in infants,” Nutrition Reviews, vol. 70, no. 9, pp. 548–552, 2012. View at Publisher · View at Google Scholar · View at Scopus
  124. J. R. Sabetta, P. DePetrillo, R. J. Cipriani, J. Smardin, L. A. Burns, and M. L. Landry, “Serum 25-hydroxyvitamin D and the incidence of acute viral respiratory tract infections in healthy adults,” PLoS ONE, vol. 5, no. 6, Article ID e11088, 2010. View at Publisher · View at Google Scholar · View at Scopus
  125. L. Coelho, S. W. Cardoso, P. M. Luz et al., “Vitamin D3 supplementation in HIV infection: effectiveness and associations with antiretroviral therapy,” Nutrition Journal, vol. 14, article 81, 2015. View at Publisher · View at Google Scholar · View at Scopus
  126. C. Thota, T. Farmer, R. E. Garfield, R. Menon, and A. Al-Hendy, “Vitamin D elicits anti-inflammatory response, inhibits contractile-associated proteins, and modulates toll-like receptors in human myometrial cells,” Reproductive Sciences, vol. 20, no. 4, pp. 463–475, 2013. View at Publisher · View at Google Scholar · View at Scopus
  127. M. Zasloff, “Fighting infections with vitamin D,” Nature Medicine, vol. 12, no. 4, pp. 388–390, 2006. View at Publisher · View at Google Scholar · View at Scopus
  128. N. Modhiran, D. Watterson, D. A. Muller et al., “Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity,” Science Translational Medicine, vol. 7, no. 304, Article ID 304ra142, 2015. View at Publisher · View at Google Scholar · View at Scopus
  129. Y.-C. Chuang, H.-Y. Lei, H.-S. Liu, Y.-S. Lin, T.-F. Fu, and T.-M. Yeh, “Macrophage migration inhibitory factor induced by dengue virus infection increases vascular permeability,” Cytokine, vol. 54, no. 2, pp. 222–231, 2011. View at Publisher · View at Google Scholar · View at Scopus
  130. N. A. Dalrymple and E. R. MacKow, “Roles for endothelial cells in dengue virus infection,” Advances in Virology, vol. 2012, Article ID 840654, 8 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  131. A. Nimer and A. Mouch, “Vitamin D improves viral response in hepatitis C genotype 2-3 naïve patients,” World Journal of Gastroenterology, vol. 18, no. 8, pp. 800–805, 2012. View at Publisher · View at Google Scholar · View at Scopus
  132. G. R. Campbell and S. A. Spector, “Toll-like receptor 8 ligands activate a vitamin D mediated autophagic response that inhibits human immunodeficiency virus type 1,” PLoS Pathogens, vol. 8, no. 11, Article ID e1003017, 2012. View at Publisher · View at Google Scholar · View at Scopus
  133. P. T. Liu, M. Schenk, V. P. Walker et al., “Convergence of IL-1β and VDR activation pathways in human TLR2/1-induced antimicrobial responses,” PLoS ONE, vol. 4, no. 6, Article ID e5810, 2009. View at Publisher · View at Google Scholar · View at Scopus
  134. P. T. Liu, S. R. Krutzik, and R. L. Modlin, “Therapeutic implications of the TLR and VDR partnership,” Trends in Molecular Medicine, vol. 13, no. 3, pp. 117–124, 2007. View at Publisher · View at Google Scholar · View at Scopus
  135. T. S. Lisse, R. F. Chun, S. Rieger, J. S. Adams, and M. Hewison, “Vitamin D activation of functionally distinct regulatory miRNAs in primary human osteoblasts,” Journal of Bone and Mineral Research, vol. 28, no. 6, pp. 1478–1488, 2013. View at Publisher · View at Google Scholar · View at Scopus
  136. T. Mohri, M. Nakajima, S. Takagi, S. Komagata, and T. Yokoi, “MicroRNA regulates human vitamin D receptor,” International Journal of Cancer, vol. 125, no. 6, pp. 1328–1333, 2009. View at Publisher · View at Google Scholar · View at Scopus
  137. E. Tsitsiou and M. A. Lindsay, “microRNAs and the immune response,” Current Opinion in Pharmacology, vol. 9, no. 4, pp. 514–520, 2009. View at Publisher · View at Google Scholar · View at Scopus
  138. L. A. O'Neill, F. J. Sheedy, and C. E. McCoy, “MicroRNAs: the fine-tuners of Toll-like receptor signalling,” Nature Reviews Immunology, vol. 11, no. 3, pp. 163–175, 2011. View at Publisher · View at Google Scholar · View at Scopus
  139. S. Essa, N. Denzer, U. Mahlknecht et al., “VDR microRNA expression and epigenetic silencing of vitamin D signaling in melanoma cells,” The Journal of Steroid Biochemistry and Molecular Biology, vol. 121, no. 1-2, pp. 110–113, 2010. View at Publisher · View at Google Scholar · View at Scopus
  140. G. Disanto, G. K. Sandve, A. J. Berlanga-Taylor et al., “Vitamin d receptor binding, chromatin states and association with multiple sclerosis,” Human Molecular Genetics, vol. 21, no. 16, Article ID dds189, pp. 3575–3586, 2012. View at Publisher · View at Google Scholar · View at Scopus
  141. F. Pereira, A. Barbáchano, P. K. Singh, M. J. Campbell, A. Muñoz, and M. J. Larriba, “Vitamin D has wide regulatory effects on histone demethylase genes,” Cell Cycle, vol. 11, no. 6, pp. 1081–1089, 2012. View at Publisher · View at Google Scholar · View at Scopus
  142. E. L. Beckett, C. Martin, K. Duesing et al., “Vitamin D receptor genotype modulates the correlation between vitamin D and circulating levels of let-7a/b and vitamin D intake in an elderly cohort,” Journal of Nutrigenetics and Nutrigenomics, vol. 7, no. 4–6, pp. 264–273, 2014. View at Publisher · View at Google Scholar · View at Scopus
  143. A. Yoshimura, T. Naka, and M. Kubo, “SOCS proteins, cytokine signalling and immune regulation,” Nature Reviews Immunology, vol. 7, no. 6, pp. 454–465, 2007. View at Publisher · View at Google Scholar · View at Scopus
  144. I. Kinjyo, T. Hanada, K. Inagaki-Ohara et al., “SOCS1/JAB is a negative regulator of LPS-induced macrophage activation,” Immunity, vol. 17, no. 5, pp. 583–591, 2002. View at Publisher · View at Google Scholar · View at Scopus
  145. M. Peters-Golden, C. Canetti, P. Mancuso, and M. J. Coffey, “Leukotrienes: underappreciated mediators of innate immune responses,” Journal of Immunology, vol. 174, no. 2, pp. 589–594, 2005. View at Publisher · View at Google Scholar · View at Scopus
  146. M. J. Coffey, S. E. Wilcoxen, S. M. Phare, R. U. Simpson, M. R. Gyetko, and M. Peters-Golden, “Reduced 5-lipoxygenase metabolism of arachidonic acid in macrophages rrom 1,25-dihydroxyvitamin D3-deficient rats,” Prostaglandins, vol. 48, no. 5, pp. 313–329, 1994. View at Publisher · View at Google Scholar · View at Scopus
  147. Z. Wang, L. R. Filgueiras, S. Wang et al., “Leukotriene B4 enhances the generation of proinflammatory micrornas to promote MyD88-dependent macrophage activation,” The Journal of Immunology, vol. 192, no. 5, pp. 2349–2356, 2014. View at Publisher · View at Google Scholar · View at Scopus
  148. M. A. Kriegel, J. E. Manson, and K. H. Costenbader, “Does vitamin D affect risk of developing autoimmune disease?: a systematic review,” Seminars in Arthritis and Rheumatism, vol. 40, no. 6, pp. 512–531.e8, 2011. View at Publisher · View at Google Scholar · View at Scopus
  149. E. K. L. Chan, M. Satoh, and K. M. Pauley, “Contrast in aberrant microRNA expression in systemic lupus erythematosus and rheumatoid arthritis: Is microRNA-146 all we need?” Arthritis and Rheumatism, vol. 60, no. 4, pp. 912–915, 2009. View at Publisher · View at Google Scholar · View at Scopus
  150. S. W. Kim, J. M. Lee, J. H. Ha et al., “Association between vitamin D receptor polymorphisms and osteoporosis in patients with COPD,” International Journal of Chronic Obstructive Pulmonary Disease, vol. 10, no. 1, pp. 1809–1817, 2015. View at Publisher · View at Google Scholar · View at Scopus
  151. J. Rashedi, M. Asgharzadeh, S. R. Moaddab et al., “Vitamin D receptor gene polymorphism and vitamin D plasma concentration: correlation with susceptibility to tuberculosis,” Advanced Pharmaceutical Bulletin, vol. 4, supplement 2, pp. 607–611, 2014. View at Publisher · View at Google Scholar
  152. Y.-W. Huang, Y.-T. Liao, W. Chen et al., “Vitamin D receptor gene polymorphisms and distinct clinical phenotypes of hepatitis B carriers in Taiwan,” Genes & Immunity, vol. 11, no. 1, pp. 87–93, 2010. View at Publisher · View at Google Scholar · View at Scopus
  153. R. Lu, M. Maduro, F. Li et al., “Animal virus replication and RNAi-mediated antiviral silencing in Caenorhabditis elegans,” Nature, vol. 436, no. 7053, pp. 1040–1043, 2005. View at Publisher · View at Google Scholar · View at Scopus
  154. S. Wu, L. He, Y. Li et al., “MiR-146a facilitates replication of dengue virus by dampening interferon induction by targeting TRAF6,” The Journal of Infection, vol. 67, no. 4, pp. 329–341, 2013. View at Publisher · View at Google Scholar · View at Scopus
  155. S. Bala, M. Marcos, K. Kodys et al., “Up-regulation of MicroRNA-155 in macrophages contributes to increased tumor necrosis factor α (TNFα) Production via increased mRNA Half-life in alcoholic liver disease,” The Journal of Biological Chemistry, vol. 286, no. 2, pp. 1436–1444, 2011. View at Publisher · View at Google Scholar
  156. P. Wang, J. Hou, L. Lin et al., “Inducible microRNA-155 feedback promotes type I IFN signaling in antiviral innate immunity by targeting suppressor of cytokine signaling 1,” The Journal of Immunology, vol. 185, no. 10, pp. 6226–6233, 2010. View at Publisher · View at Google Scholar · View at Scopus
  157. M. Jiang, R. Broering, M. Trippler et al., “MicroRNA-155 controls Toll-like receptor 3- and hepatitis C virus-induced immune responses in the liver,” Journal of Viral Hepatitis, vol. 21, no. 2, pp. 99–110, 2014. View at Publisher · View at Google Scholar · View at Scopus
  158. P.-W. Xie, Y. Xie, X.-J. Zhang et al., “Inhibition of Dengue virus 2 replication by artificial micrornas targeting the conserved regions,” Nucleic Acid Therapeutics, vol. 23, no. 4, pp. 244–252, 2013. View at Publisher · View at Google Scholar · View at Scopus
  159. J. L. Umbach and B. R. Cullen, “The role of RNAi and microRNAs in animal virus replication and antiviral immunity,” Genes & Development, vol. 23, no. 10, pp. 1151–1164, 2009. View at Publisher · View at Google Scholar · View at Scopus
  160. B. L. Heiss, O. A. Maximova, and A. G. Pletnev, “Insertion of microRNA targets into the flavivirus genome alters its highly neurovirulent phenotype,” Journal of Virology, vol. 85, no. 4, pp. 1464–1472, 2011. View at Publisher · View at Google Scholar · View at Scopus
  161. R. A. Agis-Juárez, I. Galván, F. Medina et al., “Polypyrimidine tract-binding protein is relocated to the cytoplasm and is required during dengue virus infection in Vero cells,” The Journal of General Virology, vol. 90, part 12, pp. 2893–2901, 2009. View at Publisher · View at Google Scholar
  162. L. Jiang, H. Yao, X. Duan, X. Lu, and Y. Liu, “Polypyrimidine tract-binding protein influences negative strand RNA synthesis of dengue virus,” Biochemical and Biophysical Research Communications, vol. 385, no. 2, pp. 187–192, 2009. View at Publisher · View at Google Scholar · View at Scopus
  163. R. G. Fred, C. H. Bang-Berthelsen, T. Mandrup-Poulsen, L. G. Grunnet, and N. Welsh, “High glucose suppresses human islet insulin biosynthesis by inducing Mir-133a leading to decreased polypyrimidine tract binding protein-expression,” PLoS ONE, vol. 5, no. 5, Article ID e10843, 2010. View at Publisher · View at Google Scholar · View at Scopus
  164. P. A. Tambyah, C. S. Ching, S. Sepramaniam, J. M. Ali, A. Armugam, and K. Jeyaseelan, “microRNA expression in blood of dengue patients,” Annals of Clinical Biochemistry, 2015. View at Publisher · View at Google Scholar
  165. F. Taïbi, V. Metzinger-Le Meuth, Z. A. Massy, and L. Metzinger, “MiR-223: an inflammatory oncomiR enters the cardiovascular field,” Biochimica et Biophysica Acta (BBA)—Molecular Basis of Disease, vol. 1842, no. 7, pp. 1001–1009, 2014. View at Publisher · View at Google Scholar · View at Scopus
  166. S. Matsui and Y. Ogata, “Effects of miR-223 on expression of IL-1β and IL-6 in human gingival fibroblasts,” Journal of Oral Science, vol. 58, no. 1, pp. 101–108, 2016. View at Publisher · View at Google Scholar
  167. Y. Yuzefpolskiy, F. M. Baumann, L. A. Penny, G. P. Studzinski, V. Kalia, and S. Sarkar, “Vitamin D receptor signals regulate effector and memory CD8 T cell responses to infections in mice,” The Journal of Nutrition, vol. 144, no. 12, pp. 2073–2082, 2014. View at Publisher · View at Google Scholar · View at Scopus
  168. A. Waddell, J. Zhao, and M. T. Cantorna, “NKT cells can help mediate the protective effects of 1,25-dihydroxyvitamin D3 in experimental autoimmune encephalomyelitis in mice,” International Immunology, vol. 27, no. 5, pp. 237–244, 2015. View at Publisher · View at Google Scholar · View at Scopus
  169. L. Rolf, A.-H. Muris, R. Hupperts, and J. Damoiseaux, “Vitamin D effects on B cell function in autoimmunity,” Annals of the New York Academy of Sciences, vol. 1317, no. 1, pp. 84–91, 2014. View at Publisher · View at Google Scholar · View at Scopus