Advances in Virology
Volume 2016 (2016), Article ID 1016840, 14 pages
http://dx.doi.org/10.1155/2016/1016840
Review Article
Vitamin D-Regulated MicroRNAs: Are They Protective Factors against Dengue Virus Infection?
Grupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia (UdeA), Calle 70 No. 52-51, Medellín, Colombia
Received 22 December 2015; Revised 7 April 2016; Accepted 20 April 2016
Academic Editor: Subhash C. Verma
Copyright © 2016 John F. Arboleda and Silvio Urcuqui-Inchima. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Linked References
- B. A. Beutler, “TLRs and innate immunity,” Blood, vol. 113, no. 7, pp. 1399–1407, 2009. View at Publisher · View at Google Scholar · View at Scopus
- A. Dalpke, K. Heeg, H. Bartz, and A. Baetz, “Regulation of innate immunity by suppressor of cytokine signaling (SOCS) proteins,” Immunobiology, vol. 213, no. 3-4, pp. 225–235, 2008. View at Publisher · View at Google Scholar · View at Scopus
- B. E. E. Martina, “Dengue pathogenesis: a disease driven by the host response,” Science Progress, vol. 97, part 3, pp. 197–214, 2014. View at Google Scholar
- T. Pang, M. J. Cardosa, and M. G. Guzman, “Of cascades and perfect storms: the immunopathogenesis of dengue haemorrhagic fever-dengue shock syndrome (DHF/DSS),” Immunology and Cell Biology, vol. 85, no. 1, pp. 43–45, 2007. View at Publisher · View at Google Scholar · View at Scopus
- E. van Etten, K. Stoffels, C. Gysemans, C. Mathieu, and L. Overbergh, “Regulation of vitamin D homeostasis: implications for the immune system,” Nutrition Reviews, vol. 66, no. 2, pp. S125–S134, 2008. View at Publisher · View at Google Scholar · View at Scopus
- X. Guillot, L. Semerano, N. Saidenberg-Kermanac'h, G. Falgarone, and M.-C. Boissier, “Vitamin D and inflammation,” Joint Bone Spine, vol. 77, no. 6, pp. 552–557, 2010. View at Publisher · View at Google Scholar · View at Scopus
- V. V. Costa, C. T. Fagundes, D. G. Souza, and D. M. M. Teixeira, “Inflammatory and innate immune responses in dengue infection: protection versus disease induction,” The American Journal of Pathology, vol. 182, no. 6, pp. 1950–1961, 2013. View at Publisher · View at Google Scholar
- Z. R. Brenner, A. B. Miller, L. C. Ayers, and A. Roberts, “The role of vitamin D in critical illness,” Critical Care Nursing Clinics of North America, vol. 24, no. 4, pp. 527–540, 2012. View at Publisher · View at Google Scholar · View at Scopus
- S. Ahmed, J. L. Finkelstein, A. M. Stewart et al., “Micronutrients and dengue,” The American Journal of Tropical Medicine and Hygiene, vol. 91, no. 5, pp. 1049–1056, 2014. View at Publisher · View at Google Scholar · View at Scopus
- K. Alagarasu, T. Honap, A. P. Mulay, R. V. Bachal, P. S. Shah, and D. Cecilia, “Association of vitamin D receptor gene polymorphisms with clinical outcomes of dengue virus infection,” Human Immunology, vol. 73, no. 11, pp. 1194–1199, 2012. View at Publisher · View at Google Scholar · View at Scopus
- E. Sánchez-Valdéz, M. Delgado-Aradillas, J. A. Torres-Martínez, and J. M. Torres-Benítez, “Clinical response in patients with dengue fever to oral calcium plus vitamin D administration: study of 5 cases,” Proceedings of the Western Pharmacology Society, vol. 52, pp. 14–17, 2009. View at Google Scholar · View at Scopus
- H. Loke, D. Bethell, C. X. T. Phuong et al., “Susceptibility to dengue hemorrhagic fever in vietnam: evidence of an association with variation in the vitamin D receptor and FCγ receptor IIA genes,” The American Journal of Tropical Medicine and Hygiene, vol. 67, no. 1, pp. 102–106, 2002. View at Google Scholar · View at Scopus
- J. A. Beard, A. Bearden, and R. Striker, “Vitamin D and the anti-viral state,” Journal of Clinical Virology, vol. 50, no. 3, pp. 194–200, 2011. View at Publisher · View at Google Scholar · View at Scopus
- E. Borella, G. Nesher, E. Israeli, and Y. Shoenfeld, “Vitamin D: a new anti-infective agent?” Annals of the New York Academy of Sciences, vol. 1317, no. 1, pp. 76–83, 2014. View at Publisher · View at Google Scholar · View at Scopus
- A. A. Giangreco and L. Nonn, “The sum of many small changes: microRNAs are specifically and potentially globally altered by vitamin D3 metabolites,” The Journal of Steroid Biochemistry and Molecular Biology, vol. 136, no. 1, pp. 86–93, 2013. View at Publisher · View at Google Scholar · View at Scopus
- L. He and G. J. Hannon, “MicroRNAs: small RNAs with a big role in gene regulation,” Nature Reviews. Genetics, vol. 5, no. 7, pp. 522–531, 2004. View at Publisher · View at Google Scholar
- J. Han, Y. Lee, K.-H. Yeom, Y.-K. Kim, H. Jin, and V. N. Kim, “The Drosha-DGCR8 complex in primary microRNA processing,” Genes & Development, vol. 18, no. 24, pp. 3016–3027, 2004. View at Publisher · View at Google Scholar · View at Scopus
- L.-A. MacFarlane and P. R. Murphy, “MicroRNA: biogenesis, function and role in cancer,” Current Genomics, vol. 11, no. 7, pp. 537–561, 2010. View at Publisher · View at Google Scholar · View at Scopus
- Y. Zhang, D. Y. M. Leung, B. N. Richers et al., “Vitamin D inhibits monocyte/macrophage proinflammatory cytokine production by targeting MAPK phosphatase-1,” The Journal of Immunology, vol. 188, no. 5, pp. 2127–2135, 2012. View at Publisher · View at Google Scholar · View at Scopus
- Y. Chen, W. Liu, T. Sun et al., “1,25-dihydroxyvitamin D promotes negative feedback regulation of TLR signaling via targeting microRNA-155-SOCS1 in macrophages,” The Journal of Immunology, vol. 190, no. 7, pp. 3687–3695, 2013. View at Publisher · View at Google Scholar · View at Scopus
- E. Sonkoly, M. Ståhle, and A. Pivarcsi, “MicroRNAs and immunity: novel players in the regulation of normal immune function and inflammation,” Seminars in Cancer Biology, vol. 18, no. 2, pp. 131–140, 2008. View at Publisher · View at Google Scholar · View at Scopus
- S. R. S. Hadinegoro, “The revised WHO dengue case classification: does the system need to be modified?” Paediatrics and International Child Health, vol. 32, supplement 1, pp. 33–38, 2012. View at Publisher · View at Google Scholar · View at Scopus
- M. S. Mustafa, V. Rasotgi, S. Jain, and V. Gupta, “Discovery of fifth serotype of dengue virus (DENV-5): a new public health dilemma in dengue control,” Medical Journal Armed Forces India, vol. 71, no. 1, pp. 67–70, 2015. View at Publisher · View at Google Scholar · View at Scopus
- B.-A. Coller, A. D. T. Barrett, S. J. Thomas, J. Whitehorn, and C. P. Simmons, “The pathogenesis of dengue,” Vaccine, vol. 29, no. 42, pp. 7221–7228, 2011. View at Publisher · View at Google Scholar
- A. Wilder-Smith, E.-E. Ooi, S. G. Vasudevan, and D. J. Gubler, “Update on dengue: epidemiology, virus evolution, antiviral drugs, and vaccine development,” Current Infectious Disease Reports, vol. 12, no. 3, pp. 157–164, 2010. View at Publisher · View at Google Scholar · View at Scopus
- M. E. Wilson and L. H. Chen, “Dengue: update on epidemiology,” Current Infectious Disease Reports, vol. 17, no. 1, p. 457, 2015. View at Publisher · View at Google Scholar
- S. Bhatt, P. W. Gething, O. J. Brady et al., “The global distribution and burden of dengue,” Nature, vol. 496, no. 7446, pp. 504–507, 2013. View at Publisher · View at Google Scholar · View at Scopus
- O. J. Brady, P. W. Gething, S. Bhatt et al., “Refining the global spatial limits of dengue virus transmission by evidence-based consensus,” PLoS Neglected Tropical Diseases, vol. 6, no. 8, Article ID e1760, 2012. View at Publisher · View at Google Scholar · View at Scopus
- S. B. Halstead, “Controversies in dengue pathogenesis,” Paediatrics and International Child Health, vol. 32, no. 1, pp. 5–9, 2012. View at Publisher · View at Google Scholar · View at Scopus
- S. Yacoub, J. Mongkolsapaya, and G. Screaton, “The pathogenesis of dengue,” Current Opinion in Infectious Diseases, vol. 26, no. 3, pp. 284–289, 2013. View at Publisher · View at Google Scholar
- B. E. E. Martina, P. Koraka, and A. D. M. E. Osterhaus, “Dengue virus pathogenesis: an integrated view,” Clinical Microbiology Reviews, vol. 22, no. 4, pp. 564–581, 2009. View at Publisher · View at Google Scholar · View at Scopus
- J. Flipse, J. Wilschut, and J. M. Smit, “Molecular mechanisms involved in antibody-dependent enhancement of dengue virus infection in humans,” Traffic, vol. 14, no. 1, pp. 25–35, 2013. View at Publisher · View at Google Scholar · View at Scopus
- T. Kawai and S. Akira, “The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors,” Nature Immunology, vol. 11, no. 5, pp. 373–384, 2010. View at Publisher · View at Google Scholar · View at Scopus
- S.-J. L. Wu, G. Grouard-Vogel, W. Sun et al., “Human skin Langerhans cells are targets of dengue virus infection,” Nature Medicine, vol. 6, no. 7, pp. 816–820, 2000. View at Publisher · View at Google Scholar · View at Scopus
- Z. Kou, M. Quinn, H. Chen et al., “Monocytes, but not T or B cells, are the principal target cells for dengue virus (DV) infection among human peripheral blood mononuclear cells,” Journal of Medical Virology, vol. 80, no. 1, pp. 134–146, 2008. View at Publisher · View at Google Scholar · View at Scopus
- E. G. Acosta, A. Kumar, and R. Bartenschlager, “Revisiting dengue virus-host cell interaction: new insights into molecular and cellular virology,” Advances in Virus Research, vol. 88, pp. 1–109, 2014. View at Publisher · View at Google Scholar · View at Scopus
- S. Urcuqui-Inchima, C. Patiño, S. Torres, A.-L. Haenni, and F. J. Díaz, “Recent developments in understanding dengue virus replication,” Advances in Virus Research, vol. 77, pp. 1–39, 2010. View at Publisher · View at Google Scholar · View at Scopus
- D. G. Nielsen, “The relationship of interacting immunological components in dengue pathogenesis,” Virology Journal, vol. 6, article 211, 2009. View at Publisher · View at Google Scholar · View at Scopus
- Z. Liang, S. Wu, Y. Li et al., “Activation of toll-like receptor 3 impairs the dengue virus serotype 2 replication through induction of IFN-β in cultured hepatoma cells,” PLoS ONE, vol. 6, no. 8, Article ID e23346, 2011. View at Publisher · View at Google Scholar · View at Scopus
- A. M. A. Nasirudeen, H. H. Wong, P. Thien, S. Xu, K.-P. Lam, and D. X. Liu, “RIG-I, MDA5 and TLR3 synergistically play an important role in restriction of dengue virus infection,” PLoS Neglected Tropical Diseases, vol. 5, no. 1, article e926, 2011. View at Publisher · View at Google Scholar · View at Scopus
- S. Jensen and A. R. Thomsen, “Sensing of rna viruses: a review of innate immune receptors involved in recognizing RNA virus invasion,” Journal of Virology, vol. 86, no. 6, pp. 2900–2910, 2012. View at Publisher · View at Google Scholar · View at Scopus
- J. Morrison, S. Aguirre, and A. Fernandez-Sesma, “Innate immunity evasion by dengue virus,” Viruses, vol. 4, no. 3, pp. 397–413, 2012. View at Publisher · View at Google Scholar · View at Scopus
- A. Huerta-Zepeda, C. Cabello-Gutiérrez, J. Cime-Castillo et al., “Crosstalk between coagulation and inflammation during Dengue virus infection,” Thrombosis and Haemostasis, vol. 99, no. 5, pp. 936–943, 2008. View at Publisher · View at Google Scholar · View at Scopus
- M. Yu and S. J. Levine, “Toll-like receptor 3, RIG-I-like receptors and the NLRP3 inflammasome: key modulators of innate immune responses to double-stranded RNA viruses,” Cytokine & Growth Factor Reviews, vol. 22, no. 2, pp. 63–72, 2011. View at Publisher · View at Google Scholar · View at Scopus
- M. Yoneyama, M. Kikuchi, K. Matsumoto et al., “Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity,” Journal of Immunology, vol. 175, no. 5, pp. 2851–2858, 2005. View at Publisher · View at Google Scholar · View at Scopus
- B. E. E. B. Martina, P. Koraka, and A. D. M. E. Osterhaus, “Dengue virus pathogenesis: an integrated view,” Clinical Microbiology Reviews, vol. 22, no. 4, pp. 564–581, 2009. View at Publisher · View at Google Scholar · View at Scopus
- S. M. Stamatovic, R. F. Keep, S. L. Kunkel, and A. V. Andjelkovic, “Potential role of MCP-1 in endothelial cell tight junction ‘opening’: signaling via Rho and Rho kinase,” Journal of Cell Science, vol. 116, no. 22, pp. 4615–4628, 2003. View at Publisher · View at Google Scholar · View at Scopus
- Y.-R. Lee, M.-T. Liu, H.-Y. Lei et al., “MCP1, a highly expressed chemokine in dengue haemorrhagic fever/dengue shock syndrome patients, may cause permeability change, possibly through reduced tight junctions of vascular endothelium cells,” The Journal of General Virology, vol. 87, no. 12, pp. 3623–3630, 2006. View at Publisher · View at Google Scholar · View at Scopus
- J. F. Kelley, P. H. Kaufusi, and V. R. Nerurkar, “Dengue hemorrhagic fever-associated immunomediators induced via maturation of dengue virus nonstructural 4B protein in monocytes modulate endothelial cell adhesion molecules and human microvascular endothelial cells permeability,” Virology, vol. 422, no. 2, pp. 326–337, 2012. View at Publisher · View at Google Scholar · View at Scopus
- Y. Huang, H. Lei, H. Liu, Y. Lin, C. Liu, and T. Yeh, “Dengue virus infects human endothelial cells and induces IL-6 and IL-8 production,” The American Journal of Tropical Medicine and Hygiene, vol. 63, no. 1, pp. 71–75, 2000. View at Google Scholar
- H. Puerta-Guardo, A. Raya-Sandino, L. González-Mariscal et al., “The cytokine response of U937-derived macrophages infected through antibody-dependent enhancement of dengue virus disrupts cell apical-junction complexes and increases vascular permeability,” Journal of Virology, vol. 87, no. 13, pp. 7486–7501, 2013. View at Publisher · View at Google Scholar · View at Scopus
- D. Talavera, A. M. Castillo, M. C. Dominguez, A. Escobar Gutierrez, and I. Meza, “IL8 release, tight junction and cytoskeleton dynamic reorganization conducive to permeability increase are induced by dengue virus infection of microvascular endothelial monolayers,” The Journal of General Virology, vol. 85, no. 7, pp. 1801–1813, 2004. View at Publisher · View at Google Scholar · View at Scopus
- T.-T. Tsai, Y.-J. Chuang, Y.-S. Lin, S.-W. Wan, C.-L. Chen, and C.-F. Lin, “An emerging role for the anti-inflammatory cytokine interleukin-10 in dengue virus infection,” Journal of Biomedical Science, vol. 20, no. 1, article 40, 2013. View at Publisher · View at Google Scholar · View at Scopus
- P. Liu, M. Woda, F. A. Ennis, and D. H. Libraty, “Dengue virus infection differentially regulates endothelial barrier function over time through type I interferon effects,” Journal of Infectious Diseases, vol. 200, no. 2, pp. 191–201, 2009. View at Publisher · View at Google Scholar · View at Scopus
- C. Lee, O. Buznyk, L. Kuffova et al., “Cathelicidin LL-37 and HSV-1 corneal infection: peptide versus gene therapy,” Translational Vision Science & Technology, vol. 3, no. 3, article 4, 2014. View at Publisher · View at Google Scholar
- S. Tripathi, G. Wang, M. White, L. Qi, J. Taubenberger, and K. L. Hartshorn, “Antiviral activity of the human cathelicidin, LL-37, and derived peptides on seasonal and pandemic influenza A viruses,” PLoS ONE, vol. 10, no. 4, Article ID e0124706, 2015. View at Publisher · View at Google Scholar · View at Scopus
- P. Bergman, L. Walter-Jallow, K. Broliden, B. Agerberth, and J. Söderlund, “The antimicrobial peptide LL-37 inhibits HIV-1 replication,” Current HIV Research, vol. 5, no. 4, pp. 410–415, 2007. View at Publisher · View at Google Scholar · View at Scopus
- V. Tangpricha, S. E. Judd, T. R. Ziegler et al., “LL-37 concentrations and the relationship to vitamin D, immune status, and inflammation in HIV-infected children and young adults,” AIDS Research and Human Retroviruses, vol. 30, no. 7, pp. 670–676, 2014. View at Publisher · View at Google Scholar · View at Scopus
- A. Schögler, R. J. Muster, E. Kieninger et al., “Vitamin D represses rhinovirus replication in cystic fibrosis cells by inducing LL-37,” The European Respiratory Journal, vol. 47, no. 2, pp. 520–530, 2016. View at Publisher · View at Google Scholar
- W. Aguilar-Jiménez, W. Zapata, A. Caruz, and M. T. Rugeles, “High transcript levels of vitamin D receptor are correlated with higher mRNA expression of human beta defensins and IL-10 in mucosa of HIV-1-exposed seronegative individuals,” PLoS ONE, vol. 8, no. 12, Article ID e82717, 2013. View at Publisher · View at Google Scholar · View at Scopus
- M. Gal-Tanamy, L. Bachmetov, A. Ravid et al., “Vitamin D: an innate antiviral agent suppressing hepatitis C virus in human hepatocytes,” Hepatology, vol. 54, no. 5, pp. 1570–1579, 2011. View at Publisher · View at Google Scholar · View at Scopus
- H. Farnik, J. Bojunga, A. Berger et al., “Low vitamin D serum concentration is associated with high levels of hepatitis B virus replication in chronically infected patients,” Hepatology, vol. 58, no. 4, pp. 1270–1276, 2013. View at Publisher · View at Google Scholar · View at Scopus
- S. Yokoyama, S. Takahashi, Y. Kawakami et al., “Effect of vitamin D supplementation on pegylated interferon/ribavirin therapy for chronic hepatitis C genotype 1b: a randomized controlled trial,” Journal of Viral Hepatitis, vol. 21, no. 5, pp. 348–356, 2014. View at Publisher · View at Google Scholar · View at Scopus
- B. Terrier, F. Carrat, G. Geri et al., “Low 25-OH vitamin D serum levels correlate with severe fibrosis in HIV-HCV co-infected patients with chronic hepatitis,” Journal of Hepatology, vol. 55, no. 4, pp. 756–761, 2011. View at Publisher · View at Google Scholar · View at Scopus
- G. R. Campbell and S. A. Spector, “Autophagy induction by vitamin D inhibits both Mycobacterium tuberculosis and human immunodeficiency virus type 1,” Autophagy, vol. 8, no. 10, pp. 1523–1525, 2012. View at Publisher · View at Google Scholar · View at Scopus
- G. R. Campbell and S. A. Spector, “Hormonally active vitamin D3 (1α,25-dihydroxycholecalciferol) triggers autophagy in human macrophages that inhibits HIV-1 infection,” The Journal of Biological Chemistry, vol. 286, no. 21, pp. 18890–18902, 2011. View at Publisher · View at Google Scholar · View at Scopus
- H. Guan, C. Liu, Z. Chen et al., “1,25-dihydroxyvitamin D3 up-regulates expression of hsa-let-7a-2 through the interaction of VDR/VDRE in human lung cancer A549 cells,” Gene, vol. 522, no. 2, pp. 142–146, 2013. View at Publisher · View at Google Scholar · View at Scopus
- M. Escalera-Cueto, I. Medina-Martínez, R. M. Del Angel, J. Berumen-Campos, A. L. Gutiérrez-Escolano, and M. Yocupicio-Monroy, “Let-7c overexpression inhibits dengue virus replication in human hepatoma Huh-7 cells,” Virus Research, vol. 196, pp. 105–112, 2015. View at Publisher · View at Google Scholar · View at Scopus
- N. Fitch, A. B. Becker, and K. T. HayGlass, “Vitamin D [1,25(OH)2D3] differentially regulates human innate cytokine responses to bacterial versus viral pattern recognition receptor stimuli,” The Journal of Immunology, vol. 196, no. 7, pp. 2965–2972, 2016. View at Publisher · View at Google Scholar
- E.-A. Ye and J. J. Steinle, “miR-146a attenuates inflammatory pathways mediated by TLR4/NF-κB and TNFα to protect primary human retinal microvascular endothelial cells grown in high glucose,” Mediators of Inflammation, vol. 2016, Article ID 3958453, 9 pages, 2016. View at Publisher · View at Google Scholar
- K. Sadeghi, B. Wessner, U. Laggner et al., “Vitamin D3 down-regulates monocyte TLR expression and triggers hyporesponsiveness to pathogen-associated molecular patterns,” European Journal of Immunology, vol. 36, no. 2, pp. 361–370, 2006. View at Publisher · View at Google Scholar · View at Scopus
- H. Puerta-Guardo, F. Medina, S. I. De la Cruz Hernández, V. H. Rosales, J. E. Ludert, and R. M. del Angel, “The 1α,25-dihydroxy-vitamin D3 reduces dengue virus infection in human myelomonocyte (U937) and hepatic (Huh-7) cell lines and cytokine production in the infected monocytes,” Antiviral Research, vol. 94, no. 1, pp. 57–61, 2012. View at Publisher · View at Google Scholar
- Y. Qi, Y. Li, L. Zhang, and J. Huang, “MicroRNA expression profiling and bioinformatic analysis of dengue virus-infected peripheral blood mononuclear cells,” Molecular Medicine Reports, vol. 7, no. 3, pp. 791–798, 2013. View at Publisher · View at Google Scholar · View at Scopus
- V. Gonzalez-Pardo, N. D'Elia, A. Verstuyf, R. Boland, and A. Russo de Boland, “NFκB pathway is down-regulated by 1α,25(OH)2-vitamin D3 in endothelial cells transformed by Kaposi sarcoma-associated herpes virus G protein coupled receptor,” Steroids, vol. 77, no. 11, pp. 1025–1032, 2012. View at Publisher · View at Google Scholar · View at Scopus
- D. Bhaumik, G. K. Scott, S. Schokrpur, C. K. Patil, J. Campisi, and C. C. Benz, “Expression of microRNA-146 suppresses NF-κB activity with reduction of metastatic potential in breast cancer cells,” Oncogene, vol. 27, no. 42, pp. 5643–5647, 2008. View at Publisher · View at Google Scholar · View at Scopus
- Y. Chen, J. Zhang, X. Ge, J. Du, D. K. Deb, and Y. C. Li, “Vitamin D receptor inhibits nuclear factor κb activation by interacting with IκB kinase β protein,” The Journal of Biological Chemistry, vol. 288, no. 27, pp. 19450–19458, 2013. View at Publisher · View at Google Scholar · View at Scopus
- L. J. Dickie, L. D. Church, L. R. Coulthard, R. J. Mathews, P. Emery, and M. F. McDermott, “Vitamin D3 down-regulates intracellular Toll-like receptor 9 expression and Toll-like receptor 9-induced IL-6 production in human monocytes,” Rheumatology, vol. 49, no. 8, pp. 1466–1471, 2010. View at Publisher · View at Google Scholar
- H. Yan, Y. Zhou, Y. Liu, Y. Deng, S. Puthiyakunnon, and X. Chen, “miR-252 of the Asian tiger mosquito Aedes albopictus regulates dengue virus replication by suppressing the expression of the dengue virus envelope protein,” Journal of Medical Virology, vol. 86, no. 8, pp. 1428–1436, 2014. View at Publisher · View at Google Scholar · View at Scopus
- X. Zhu, Z. He, Y. Hu et al., “MicroRNA-30e∗ suppresses dengue virus replication by promoting NF-κB-dependent IFN production,” PLoS Neglected Tropical Diseases, vol. 8, no. 8, p. e3088, 2014. View at Publisher · View at Google Scholar
- R.-F. Chen, K. D. Yang, I.-K. Lee et al., “Augmented miR-150 expression associated with depressed SOCS1 expression involved in dengue haemorrhagic fever,” The Journal of Infection, vol. 69, no. 4, pp. 366–374, 2014. View at Publisher · View at Google Scholar · View at Scopus
- T.-C. Lee, Y.-L. Lin, J.-T. Liao et al., “Utilizing liver-specific microRNA-122 to modulate replication of dengue virus replicon,” Biochemical and Biophysical Research Communications, vol. 396, no. 3, pp. 596–601, 2010. View at Publisher · View at Google Scholar · View at Scopus
- A. M. Pham, R. A. Langlois, and B. R. tenOever, “Replication in cells of hematopoietic origin is necessary for dengue virus dissemination,” PLoS Pathogens, vol. 8, no. 1, Article ID e1002465, 2012. View at Publisher · View at Google Scholar · View at Scopus
- P. L. Boutz, G. Chawla, P. Stoilov, and D. L. Black, “MicroRNAs regulate the expression of the alternative splicing factor nPTB during muscle development,” Genes & Development, vol. 21, no. 1, pp. 71–84, 2007. View at Publisher · View at Google Scholar · View at Scopus
- J. A. Castillo, J. C. Castrillón, M. Diosa-Toro et al., “Complex interaction between dengue virus replication and expression of miRNA-133a,” BMC Infectious Diseases, vol. 16, no. 1, article 29, 2015. View at Publisher · View at Google Scholar
- W. Wen, Z. He, Q. Jing et al., “Cellular microRNA-miR-548g-3p modulates the replication of dengue virus,” The Journal of Infection, vol. 70, no. 6, pp. 631–640, 2015. View at Publisher · View at Google Scholar
- N. Wu, N. Gao, D. Fan, J. Wei, J. Zhang, and J. An, “miR-223 inhibits dengue virus replication by negatively regulating the microtubule-destabilizing protein STMN1 in EAhy926 cells,” Microbes and Infection, vol. 16, no. 11, pp. 911–922, 2014. View at Publisher · View at Google Scholar
- A. K. I. Falconar, “The dengue virus nonstructural-1 protein (NS1) generates antibodies to common epitopes on human blood clotting, integrin/adhesin proteins and binds to human endothelial cells: Potential implications in haemorrhagic fever pathogenesis,” Archives of Virology, vol. 142, no. 5, pp. 897–916, 1997. View at Publisher · View at Google Scholar · View at Scopus
- A. L. Rothman, “Immunity to dengue virus: a tale of original antigenic sin and tropical cytokine storms,” Nature Reviews Immunology, vol. 11, no. 8, pp. 532–543, 2011. View at Publisher · View at Google Scholar · View at Scopus
- T.-M. Yeh, S.-H. Liu, K.-C. Lin et al., “Dengue virus enhances thrombomodulin and ICAM-1 expression through the macrophage migration inhibitory factor induction of the MAPK and PI3K signaling pathways,” PLoS ONE, vol. 8, no. 1, Article ID e55018, 2013. View at Publisher · View at Google Scholar · View at Scopus
- K. Ellencrona, A. Syed, and M. Johansson, “Flavivirus NS5 associates with host-cell proteins zonula occludens-1 (ZO-1) and regulating synaptic membrane exocytosis-2 (RIMS2) via an internal PDZ binding mechanism,” Biological Chemistry, vol. 390, no. 4, pp. 319–323, 2009. View at Publisher · View at Google Scholar · View at Scopus
- M. D. de Kruif, T. E. Setiati, A. T. A. Mairuhu et al., “Differential gene expression changes in children with severe dengue virus infections,” PLoS Neglected Tropical Diseases, vol. 2, no. 4, article e215, 2008. View at Publisher · View at Google Scholar · View at Scopus
- S. Ubol, P. Masrinoul, J. Chaijaruwanich, S. Kalayanarooj, T. Charoensirisuthikul, and J. Kasisith, “Differences in global gene expression in peripheral blood mononuclear cells indicate a significant role of the innate responses in progression of dengue fever but not dengue hemorrhagic fever,” The Journal of Infectious Diseases, vol. 197, no. 10, pp. 1459–1467, 2008. View at Publisher · View at Google Scholar · View at Scopus
- J. Chen, M. M.-L. Ng, and J. J. H. Chu, “Activation of TLR2 and TLR6 by dengue NS1 protein and its implications in the immunopathogenesis of dengue virus infection,” PLoS Pathogens, vol. 11, no. 7, Article ID e1005053, 2015. View at Publisher · View at Google Scholar · View at Scopus
- P. R. Beatty, H. Puerta-Guardo, S. S. Killingbeck, D. R. Glasner, K. Hopkins, and E. Harris, “Dengue virus NS1 triggers endothelial permeability and vascular leak that is prevented by NS1 vaccination,” Science Translational Medicine, vol. 7, no. 304, Article ID 304ra141, 2015. View at Publisher · View at Google Scholar · View at Scopus
- S. Torres, J. C. Hernández, D. Giraldo et al., “Differential expression of Toll-like receptors in dendritic cells of patients with dengue during early and late acute phases of the disease,” PLoS Neglected Tropical Diseases, vol. 7, no. 2, Article ID e2060, 2013. View at Publisher · View at Google Scholar · View at Scopus
- S. Pagni and A. Fernandez-Sesma, “Evasion of the human innate immune system by dengue virus,” Immunologic Research, vol. 54, no. 1–3, pp. 152–159, 2012. View at Publisher · View at Google Scholar · View at Scopus
- J. L. Muñoz-Jordán, M. Laurent-Rolle, J. Ashour et al., “Inhibition of alpha/beta interferon signaling by the NS4B protein of flaviviruses,” Journal of Virology, vol. 79, no. 13, pp. 8004–8013, 2005. View at Publisher · View at Google Scholar · View at Scopus
- J. L. Miller, B. J. M. deWet, L. Martinez-Pomares et al., “The mannose receptor mediates dengue virus infection of macrophages,” PLoS Pathogens, vol. 4, no. 2, article e17, 2008. View at Publisher · View at Google Scholar · View at Scopus
- M.-F. Wu, S.-T. Chen, A.-H. Yang et al., “CLEC5A is critical for dengue virus-induced inflammasome activation in human macrophages,” Blood, vol. 121, no. 1, pp. 95–106, 2013. View at Publisher · View at Google Scholar · View at Scopus
- E. Schaeffer, V. Flacher, V. Papageorgiou et al., “Dermal CD14+ dendritic cell and macrophage infection by dengue virus is stimulated by interleukin-4,” Journal of Investigative Dermatology, vol. 135, no. 7, pp. 1743–1751, 2015. View at Publisher · View at Google Scholar
- M.-F. Wu, S.-T. Chen, and S.-L. Hsieh, “Distinct regulation of dengue virus-induced inflammasome activation in human macrophage subsets,” Journal of Biomedical Science, vol. 20, no. 1, article 36, 2013. View at Publisher · View at Google Scholar · View at Scopus
- T. Dong, E. Moran, N. Vinh Chau et al., “High pro-inflammatory cytokine secretion and loss of high avidity cross-reactive cytotoxic T-cells during the course of secondary dengue virus infection,” PLoS ONE, vol. 2, no. 12, Article ID e1192, 2007. View at Publisher · View at Google Scholar · View at Scopus
- F. Baeke, T. Takiishi, H. Korf, C. Gysemans, and C. Mathieu, “Vitamin D: modulator of the immune system,” Current Opinion in Pharmacology, vol. 10, no. 4, pp. 482–496, 2010. View at Publisher · View at Google Scholar · View at Scopus
- M. Hewison, “Vitamin D and the intracrinology of innate immunity,” Molecular and Cellular Endocrinology, vol. 321, no. 2, pp. 103–111, 2010. View at Publisher · View at Google Scholar · View at Scopus
- C. L. Greiller and A. R. Martineau, “Modulation of the immune response to respiratory viruses by vitamin D,” Nutrients, vol. 7, no. 6, pp. 4240–4270, 2015. View at Publisher · View at Google Scholar · View at Scopus
- A. K. Coussens, A. R. Martineau, and R. J. Wilkinson, “Anti-inflammatory and antimicrobial actions of vitamin D in combating TB/HIV,” Scientifica, vol. 2014, Article ID 903680, 13 pages, 2014. View at Publisher · View at Google Scholar
- S. Christakos, D. V. Ajibade, P. Dhawan, A. J. Fechner, and L. J. Mady, “Vitamin D: metabolism,” Endocrinology and Metabolism Clinics of North America, vol. 39, no. 2, pp. 243–253, 2010. View at Publisher · View at Google Scholar · View at Scopus
- S. Christakos, P. Dhawan, Q. Shen, X. Peng, B. Benn, and Y. Zhong, “New insights into the mechanisms involved in the pleiotropic actions of 1,25dihydroxyvitamin D3,” Annals of the New York Academy of Sciences, vol. 1068, no. 1, pp. 194–203, 2006. View at Publisher · View at Google Scholar · View at Scopus
- A. S. Dusso and A. J. Brown, “Mechanism of vitamin D action and its regulation,” American Journal of Kidney Diseases, vol. 32, no. 2, supplement 2, pp. S13–S24, 1998. View at Publisher · View at Google Scholar · View at Scopus
- J. S. Adams and M. Hewison, “Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity,” Nature Clinical Practice Endocrinology and Metabolism, vol. 4, no. 2, pp. 80–90, 2008. View at Publisher · View at Google Scholar · View at Scopus
- R. F. Chun, J. S. Adams, and M. Hewison, “Back to the future: a new look at ‘old’ vitamin D,” The Journal of Endocrinology, vol. 198, no. 2, pp. 261–269, 2008. View at Publisher · View at Google Scholar · View at Scopus
- M. Hewison, “Vitamin D and the immune system: new perspectives on an old theme,” Endocrinology and Metabolism Clinics of North America, vol. 39, no. 2, pp. 365–379, 2010. View at Publisher · View at Google Scholar · View at Scopus
- M. Hewison, “Vitamin D and innate immunity,” Current Opinion in Investigational Drugs, vol. 9, no. 5, pp. 485–490, 2008. View at Google Scholar
- M. Hewison, “Vitamin D and innate and adaptive immunity,” Vitamins and Hormones, vol. 86, pp. 23–62, 2011. View at Publisher · View at Google Scholar · View at Scopus
- M. Etminani-Esfahani, H. Khalili, N. Soleimani et al., “Serum vitamin D concentration and potential risk factors for its deficiency in HIV positive individuals,” Current HIV Research, vol. 10, no. 2, pp. 165–170, 2012. View at Publisher · View at Google Scholar · View at Scopus
- G. R. Campbell and S. A. Spector, “Vitamin D inhibits human immunodeficiency virus type 1 and Mycobacterium tuberculosis infection in macrophages through the induction of autophagy,” PLoS Pathogens, vol. 8, no. 5, Article ID e1002689, 2012. View at Publisher · View at Google Scholar · View at Scopus
- P. T. Liu, S. Stenger, H. Li et al., “Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response,” Science, vol. 311, no. 5768, pp. 1770–1773, 2006. View at Publisher · View at Google Scholar · View at Scopus
- Y. Zhao, B. Yu, X. Mao et al., “Effect of 25-hydroxyvitamin D3 on rotavirus replication and gene expressions of RIG-I signalling molecule in porcine rotavirus-infected IPEC-J2 cells,” Archives of Animal Nutrition, vol. 69, no. 3, pp. 227–235, 2015. View at Publisher · View at Google Scholar
- M. Reinholz and J. Schauber, “Vitamin D and innate immunity of the skin,” Deutsche Medizinische Wochenschrift, vol. 137, no. 46, pp. 2385–2389, 2012. View at Publisher · View at Google Scholar · View at Scopus
- I. Szymczak and R. Pawliczak, “The active metabolite of vitamin D3 as a potential immunomodulator,” Scandinavian Journal of Immunology, vol. 83, no. 2, pp. 83–91, 2016. View at Publisher · View at Google Scholar
- H. A. Bischoff-Ferrari, B. Dawson-Hughes, A. Platz et al., “Effect of high-dosage cholecalciferol and extended physiotherapy on complications after hip fracture: a randomized controlled trial,” Archives of Internal Medicine, vol. 170, no. 9, pp. 813–820, 2010. View at Publisher · View at Google Scholar · View at Scopus
- P. O. Lang, N. Samaras, D. Samaras, and R. Aspinall, “How important is vitamin D in preventing infections?” Osteoporosis International, vol. 24, no. 5, pp. 1537–1553, 2013. View at Publisher · View at Google Scholar · View at Scopus
- C. S. Maxwell, E. T. Carbone, and R. J. Wood, “Better newborn vitamin D status lowers RSV-associated bronchiolitis in infants,” Nutrition Reviews, vol. 70, no. 9, pp. 548–552, 2012. View at Publisher · View at Google Scholar · View at Scopus
- J. R. Sabetta, P. DePetrillo, R. J. Cipriani, J. Smardin, L. A. Burns, and M. L. Landry, “Serum 25-hydroxyvitamin D and the incidence of acute viral respiratory tract infections in healthy adults,” PLoS ONE, vol. 5, no. 6, Article ID e11088, 2010. View at Publisher · View at Google Scholar · View at Scopus
- L. Coelho, S. W. Cardoso, P. M. Luz et al., “Vitamin D3 supplementation in HIV infection: effectiveness and associations with antiretroviral therapy,” Nutrition Journal, vol. 14, article 81, 2015. View at Publisher · View at Google Scholar · View at Scopus
- C. Thota, T. Farmer, R. E. Garfield, R. Menon, and A. Al-Hendy, “Vitamin D elicits anti-inflammatory response, inhibits contractile-associated proteins, and modulates toll-like receptors in human myometrial cells,” Reproductive Sciences, vol. 20, no. 4, pp. 463–475, 2013. View at Publisher · View at Google Scholar · View at Scopus
- M. Zasloff, “Fighting infections with vitamin D,” Nature Medicine, vol. 12, no. 4, pp. 388–390, 2006. View at Publisher · View at Google Scholar · View at Scopus
- N. Modhiran, D. Watterson, D. A. Muller et al., “Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity,” Science Translational Medicine, vol. 7, no. 304, Article ID 304ra142, 2015. View at Publisher · View at Google Scholar · View at Scopus
- Y.-C. Chuang, H.-Y. Lei, H.-S. Liu, Y.-S. Lin, T.-F. Fu, and T.-M. Yeh, “Macrophage migration inhibitory factor induced by dengue virus infection increases vascular permeability,” Cytokine, vol. 54, no. 2, pp. 222–231, 2011. View at Publisher · View at Google Scholar · View at Scopus
- N. A. Dalrymple and E. R. MacKow, “Roles for endothelial cells in dengue virus infection,” Advances in Virology, vol. 2012, Article ID 840654, 8 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
- A. Nimer and A. Mouch, “Vitamin D improves viral response in hepatitis C genotype 2-3 naïve patients,” World Journal of Gastroenterology, vol. 18, no. 8, pp. 800–805, 2012. View at Publisher · View at Google Scholar · View at Scopus
- G. R. Campbell and S. A. Spector, “Toll-like receptor 8 ligands activate a vitamin D mediated autophagic response that inhibits human immunodeficiency virus type 1,” PLoS Pathogens, vol. 8, no. 11, Article ID e1003017, 2012. View at Publisher · View at Google Scholar · View at Scopus
- P. T. Liu, M. Schenk, V. P. Walker et al., “Convergence of IL-1β and VDR activation pathways in human TLR2/1-induced antimicrobial responses,” PLoS ONE, vol. 4, no. 6, Article ID e5810, 2009. View at Publisher · View at Google Scholar · View at Scopus
- P. T. Liu, S. R. Krutzik, and R. L. Modlin, “Therapeutic implications of the TLR and VDR partnership,” Trends in Molecular Medicine, vol. 13, no. 3, pp. 117–124, 2007. View at Publisher · View at Google Scholar · View at Scopus
- T. S. Lisse, R. F. Chun, S. Rieger, J. S. Adams, and M. Hewison, “Vitamin D activation of functionally distinct regulatory miRNAs in primary human osteoblasts,” Journal of Bone and Mineral Research, vol. 28, no. 6, pp. 1478–1488, 2013. View at Publisher · View at Google Scholar · View at Scopus
- T. Mohri, M. Nakajima, S. Takagi, S. Komagata, and T. Yokoi, “MicroRNA regulates human vitamin D receptor,” International Journal of Cancer, vol. 125, no. 6, pp. 1328–1333, 2009. View at Publisher · View at Google Scholar · View at Scopus
- E. Tsitsiou and M. A. Lindsay, “microRNAs and the immune response,” Current Opinion in Pharmacology, vol. 9, no. 4, pp. 514–520, 2009. View at Publisher · View at Google Scholar · View at Scopus
- L. A. O'Neill, F. J. Sheedy, and C. E. McCoy, “MicroRNAs: the fine-tuners of Toll-like receptor signalling,” Nature Reviews Immunology, vol. 11, no. 3, pp. 163–175, 2011. View at Publisher · View at Google Scholar · View at Scopus
- S. Essa, N. Denzer, U. Mahlknecht et al., “VDR microRNA expression and epigenetic silencing of vitamin D signaling in melanoma cells,” The Journal of Steroid Biochemistry and Molecular Biology, vol. 121, no. 1-2, pp. 110–113, 2010. View at Publisher · View at Google Scholar · View at Scopus
- G. Disanto, G. K. Sandve, A. J. Berlanga-Taylor et al., “Vitamin d receptor binding, chromatin states and association with multiple sclerosis,” Human Molecular Genetics, vol. 21, no. 16, Article ID dds189, pp. 3575–3586, 2012. View at Publisher · View at Google Scholar · View at Scopus
- F. Pereira, A. Barbáchano, P. K. Singh, M. J. Campbell, A. Muñoz, and M. J. Larriba, “Vitamin D has wide regulatory effects on histone demethylase genes,” Cell Cycle, vol. 11, no. 6, pp. 1081–1089, 2012. View at Publisher · View at Google Scholar · View at Scopus
- E. L. Beckett, C. Martin, K. Duesing et al., “Vitamin D receptor genotype modulates the correlation between vitamin D and circulating levels of let-7a/b and vitamin D intake in an elderly cohort,” Journal of Nutrigenetics and Nutrigenomics, vol. 7, no. 4–6, pp. 264–273, 2014. View at Publisher · View at Google Scholar · View at Scopus
- A. Yoshimura, T. Naka, and M. Kubo, “SOCS proteins, cytokine signalling and immune regulation,” Nature Reviews Immunology, vol. 7, no. 6, pp. 454–465, 2007. View at Publisher · View at Google Scholar · View at Scopus
- I. Kinjyo, T. Hanada, K. Inagaki-Ohara et al., “SOCS1/JAB is a negative regulator of LPS-induced macrophage activation,” Immunity, vol. 17, no. 5, pp. 583–591, 2002. View at Publisher · View at Google Scholar · View at Scopus
- M. Peters-Golden, C. Canetti, P. Mancuso, and M. J. Coffey, “Leukotrienes: underappreciated mediators of innate immune responses,” Journal of Immunology, vol. 174, no. 2, pp. 589–594, 2005. View at Publisher · View at Google Scholar · View at Scopus
- M. J. Coffey, S. E. Wilcoxen, S. M. Phare, R. U. Simpson, M. R. Gyetko, and M. Peters-Golden, “Reduced 5-lipoxygenase metabolism of arachidonic acid in macrophages rrom 1,25-dihydroxyvitamin D3-deficient rats,” Prostaglandins, vol. 48, no. 5, pp. 313–329, 1994. View at Publisher · View at Google Scholar · View at Scopus
- Z. Wang, L. R. Filgueiras, S. Wang et al., “Leukotriene B4 enhances the generation of proinflammatory micrornas to promote MyD88-dependent macrophage activation,” The Journal of Immunology, vol. 192, no. 5, pp. 2349–2356, 2014. View at Publisher · View at Google Scholar · View at Scopus
- M. A. Kriegel, J. E. Manson, and K. H. Costenbader, “Does vitamin D affect risk of developing autoimmune disease?: a systematic review,” Seminars in Arthritis and Rheumatism, vol. 40, no. 6, pp. 512–531.e8, 2011. View at Publisher · View at Google Scholar · View at Scopus
- E. K. L. Chan, M. Satoh, and K. M. Pauley, “Contrast in aberrant microRNA expression in systemic lupus erythematosus and rheumatoid arthritis: Is microRNA-146 all we need?” Arthritis and Rheumatism, vol. 60, no. 4, pp. 912–915, 2009. View at Publisher · View at Google Scholar · View at Scopus
- S. W. Kim, J. M. Lee, J. H. Ha et al., “Association between vitamin D receptor polymorphisms and osteoporosis in patients with COPD,” International Journal of Chronic Obstructive Pulmonary Disease, vol. 10, no. 1, pp. 1809–1817, 2015. View at Publisher · View at Google Scholar · View at Scopus
- J. Rashedi, M. Asgharzadeh, S. R. Moaddab et al., “Vitamin D receptor gene polymorphism and vitamin D plasma concentration: correlation with susceptibility to tuberculosis,” Advanced Pharmaceutical Bulletin, vol. 4, supplement 2, pp. 607–611, 2014. View at Publisher · View at Google Scholar
- Y.-W. Huang, Y.-T. Liao, W. Chen et al., “Vitamin D receptor gene polymorphisms and distinct clinical phenotypes of hepatitis B carriers in Taiwan,” Genes & Immunity, vol. 11, no. 1, pp. 87–93, 2010. View at Publisher · View at Google Scholar · View at Scopus
- R. Lu, M. Maduro, F. Li et al., “Animal virus replication and RNAi-mediated antiviral silencing in Caenorhabditis elegans,” Nature, vol. 436, no. 7053, pp. 1040–1043, 2005. View at Publisher · View at Google Scholar · View at Scopus
- S. Wu, L. He, Y. Li et al., “MiR-146a facilitates replication of dengue virus by dampening interferon induction by targeting TRAF6,” The Journal of Infection, vol. 67, no. 4, pp. 329–341, 2013. View at Publisher · View at Google Scholar · View at Scopus
- S. Bala, M. Marcos, K. Kodys et al., “Up-regulation of MicroRNA-155 in macrophages contributes to increased tumor necrosis factor α (TNFα) Production via increased mRNA Half-life in alcoholic liver disease,” The Journal of Biological Chemistry, vol. 286, no. 2, pp. 1436–1444, 2011. View at Publisher · View at Google Scholar
- P. Wang, J. Hou, L. Lin et al., “Inducible microRNA-155 feedback promotes type I IFN signaling in antiviral innate immunity by targeting suppressor of cytokine signaling 1,” The Journal of Immunology, vol. 185, no. 10, pp. 6226–6233, 2010. View at Publisher · View at Google Scholar · View at Scopus
- M. Jiang, R. Broering, M. Trippler et al., “MicroRNA-155 controls Toll-like receptor 3- and hepatitis C virus-induced immune responses in the liver,” Journal of Viral Hepatitis, vol. 21, no. 2, pp. 99–110, 2014. View at Publisher · View at Google Scholar · View at Scopus
- P.-W. Xie, Y. Xie, X.-J. Zhang et al., “Inhibition of Dengue virus 2 replication by artificial micrornas targeting the conserved regions,” Nucleic Acid Therapeutics, vol. 23, no. 4, pp. 244–252, 2013. View at Publisher · View at Google Scholar · View at Scopus
- J. L. Umbach and B. R. Cullen, “The role of RNAi and microRNAs in animal virus replication and antiviral immunity,” Genes & Development, vol. 23, no. 10, pp. 1151–1164, 2009. View at Publisher · View at Google Scholar · View at Scopus
- B. L. Heiss, O. A. Maximova, and A. G. Pletnev, “Insertion of microRNA targets into the flavivirus genome alters its highly neurovirulent phenotype,” Journal of Virology, vol. 85, no. 4, pp. 1464–1472, 2011. View at Publisher · View at Google Scholar · View at Scopus
- R. A. Agis-Juárez, I. Galván, F. Medina et al., “Polypyrimidine tract-binding protein is relocated to the cytoplasm and is required during dengue virus infection in Vero cells,” The Journal of General Virology, vol. 90, part 12, pp. 2893–2901, 2009. View at Publisher · View at Google Scholar
- L. Jiang, H. Yao, X. Duan, X. Lu, and Y. Liu, “Polypyrimidine tract-binding protein influences negative strand RNA synthesis of dengue virus,” Biochemical and Biophysical Research Communications, vol. 385, no. 2, pp. 187–192, 2009. View at Publisher · View at Google Scholar · View at Scopus
- R. G. Fred, C. H. Bang-Berthelsen, T. Mandrup-Poulsen, L. G. Grunnet, and N. Welsh, “High glucose suppresses human islet insulin biosynthesis by inducing Mir-133a leading to decreased polypyrimidine tract binding protein-expression,” PLoS ONE, vol. 5, no. 5, Article ID e10843, 2010. View at Publisher · View at Google Scholar · View at Scopus
- P. A. Tambyah, C. S. Ching, S. Sepramaniam, J. M. Ali, A. Armugam, and K. Jeyaseelan, “microRNA expression in blood of dengue patients,” Annals of Clinical Biochemistry, 2015. View at Publisher · View at Google Scholar
- F. Taïbi, V. Metzinger-Le Meuth, Z. A. Massy, and L. Metzinger, “MiR-223: an inflammatory oncomiR enters the cardiovascular field,” Biochimica et Biophysica Acta (BBA)—Molecular Basis of Disease, vol. 1842, no. 7, pp. 1001–1009, 2014. View at Publisher · View at Google Scholar · View at Scopus
- S. Matsui and Y. Ogata, “Effects of miR-223 on expression of IL-1β and IL-6 in human gingival fibroblasts,” Journal of Oral Science, vol. 58, no. 1, pp. 101–108, 2016. View at Publisher · View at Google Scholar
- Y. Yuzefpolskiy, F. M. Baumann, L. A. Penny, G. P. Studzinski, V. Kalia, and S. Sarkar, “Vitamin D receptor signals regulate effector and memory CD8 T cell responses to infections in mice,” The Journal of Nutrition, vol. 144, no. 12, pp. 2073–2082, 2014. View at Publisher · View at Google Scholar · View at Scopus
- A. Waddell, J. Zhao, and M. T. Cantorna, “NKT cells can help mediate the protective effects of 1,25-dihydroxyvitamin D3 in experimental autoimmune encephalomyelitis in mice,” International Immunology, vol. 27, no. 5, pp. 237–244, 2015. View at Publisher · View at Google Scholar · View at Scopus
- L. Rolf, A.-H. Muris, R. Hupperts, and J. Damoiseaux, “Vitamin D effects on B cell function in autoimmunity,” Annals of the New York Academy of Sciences, vol. 1317, no. 1, pp. 84–91, 2014. View at Publisher · View at Google Scholar · View at Scopus