Adapted Lethality: What We Can Learn from Guinea Pig-Adapted Ebola Virus Infection Model

Figure 4

Complement activity in the intact and prevaccinated guinea pigs infected with lethal GPA-EBOV-8mc strain or nonlethal wild-type EBOV Mayinga strain. Animals infected with nonlethal influenza virus A/Aichi/2/68 (H3N2) strain, intact animals, and guinea pigs vaccinated with inactivated nonlethal Mayinga strain EBOV while not infected were used as different controls of complement activity. Slow lagging dynamics of complement activity in guinea pigs infected with nonlethal Mayinga strain EBOV is contrasting to the rapid onset/drop peak of complement activity in the intact and prevaccinated animals infected with a lethal 8mc strain GPA-EBOV.