Herpes Simplex Virus Latency: The DNA Repair-Centered Pathway

Figure 2

Illustration of HSV1 entry into latency and reactivation as proposed in the DNA repair-centered pathway. Note that DNA damage response proteins are not activated following entry of HSV1 into neurons, a condition that permits virus entry into latency. Note also that reactivation occurs following an accumulation of DNA damage in the latently infected cell. Reactivation results in HSV1 replication in the neuron as illustrated here.