HBV Core Promoter Inhibition by Tubulin Polymerization Inhibitor (SRI-32007)

Figure 3

Activity of SRI-32007 in the HBV infectious virus assay in HepG2-NTCP cells. HepG2-NTCP cells were treated with different concentrations of Myrcludex B (a) and SRI-32007 (b) either 0.5 hours before infection or 72 hours postinfection with HBV. HBe Ag levels (mean ± standard deviation) in the culture supernatant as measured by ELISA seven days postinfection normalized to the untreated virus controls are shown in the figure.

(a)

(b)