In Vitro Comparison of the Internal Ribosomal Entry Site Activity from Rodent Hepacivirus and Pegivirus and Construction of Pseudoparticles

Figure 1

Predicted RNA secondary structures within HCV, RHV, RHV1, RHV2, RHV3, RHV-rn1, and RPgV 5′ UTR. The sequence corresponding to the mir-122 binding sites within the 5′ UTR is highlighted in orange; the first binding sites are represented by filled circles and the second by the outline. HCV contains two mir-122 binding sites and RHV, RHV1, and RHV-rn1 contain one predicted binding site. RHV2/3 and RPgV do not contain a mir-122 binding site. The nucleotides corresponding to the AUG start codon are highlighted by filled green circles.