The BioFire® RP2.1 Panel Did Not Identify Concurrent Respiratory Virus Infection in Adults with Variable SARS-CoV-2 Disease Severity and Infection Duration

Figure 1

Viral load correlations with infectious viral titer and disease severity. (a, d) Viral loads for cohorts 1 and 2, determined by qRT-PCR as SARS-CoV-2 N1 RNA copies per NP swab. The red dashed line indicates limit of detection at 2,273.5 N1 copies/swab. (b, e) Infectious virus titers for cohorts 1 and 2, determined by plaque assay as plaque-forming units (PFU) per ml. The red dashed line indicates limit of detection at 12 PFU/ml. (c, f) Correlation between viral load and infectious virus titer for cohorts 1 and 2. Statistical correlation was determined by the Spearman nonparametric test. (g, h) Correlation between viral loads and COVID-19 severity for cohorts 1 and 2. Statistical correlation was determined by the Spearman nonparametric test. The red dashed line indicates the limit of detection. (i, j) Cohort 1 viral load and disease severity in patients with pneumonia compared to patients without pneumonia. Statistical association was determined by the Mann–Whitney nonparametric test (). The red dashed line indicates limit of detection.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)

(i)

(j)