In-Silico Exploration of Plant Metabolites as Potential Remedies of Norovirus

Table 4

Toxicity parameter of selected chemicals.

Toxicity parameter	Metabolites name
	Avicularin	Asiatic acid	Curcumin	Guaijaverin
AMES toxicity	No	No	No	No
Max. Tolerated dose (log mg/kg/day)	0.576	0.078	0.081	0.494
hERG I inhibitor	No	No	No	No
hERG II inhibitors	No	No	No	Yes
Oral rat acute toxicity, LD50 (mol/kg)	2.543	2.592	1.833	2.585
Hepatotoxicity	No	No	No	No
Skin sensitisation	No	No	No	No
Minnow toxicity (log mM)	6.668	1.106	−0.081	5.071