Metal Chelates of Sulfafurazole Azo Dye Derivative: Synthesis, Structure Affirmation, Antimicrobial, Antitumor, DNA Binding, and Molecular Docking Simulation
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Bioinorganic Chemistry and Applications publishes research in all aspects of bioinorganic chemistry, including bioorganometallic chemistry and applied bioinorganic chemistry, and applications in fields such as medicine and immunology.
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Chief Editor, Professor Fanizzi, is based at the Università del Salento. His research interests and current projects are related to the study of transition metals (Platinum in particular), coordination organometallic and bioinorganic chemistry, and the applications of high field NMR Spectroscopy.
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More articlesDiscovery of New Ligand with Quinoline Scaffold as Potent Allosteric Inhibitor of HIV-1 and Its Copper Complexes as a Powerful Catalyst for the Synthesis of Chiral Benzimidazole Derivatives, and in Silico Anti-HIV-1 Studies
In this paper, the novel Schiff base ligand containing quinoline moiety and its novel copper chelate complexes were successfully prepared. The catalytic activity of the final complex in the organic reaction such as synthesis of chiral benzimidazoles and anti-HIV-1 activity of Schiff base ligand and the products of this reaction were investigated. In addition, green chemistry reactions using microwaves, powerful catalyst synthesis, green recovery and reusability, and separation of products with economic, safe, and clean methods (green chemistry) are among the advantages of this protocol. The potency of these compounds as anti-HIV-1 agents was investigated using molecular docking into integrase (IN) enzyme with code 1QS4 and the GROMACS software for molecular dynamics simulation. The final steps were evaluated in case of RMSD, RMSF, and Rg. The results revealed that the compound VII exhibit a good binding affinity to integrase ( = −10.99 kcal/mol) during 100 ns simulation time, and the analysis of RMSD suggested that compound VII was stable in the binding site of integrase.
Biosynthesis-Based Al2O3 Nanofiller from Cymbopogon citratus Leaf/Jute/Hemp/Epoxy-Based Hybrid Composites with Superior Mechanical Properties
Metallic nanoparticles (NPs) manufactured by ecofriendly strategies have also received much interest because of their elastic scattering properties and performance in nanomaterials. Aluminium oxide nanomaterials stand out among nanomaterials due to their tremendous uses in ceramic products, fabrics, therapeutic agents, catalyst supports, sewage sludge, and biosensors. The current paper investigates the effect of the nanoparticle composition and layer sequential on the mechanical characteristics of jute (J)-hemp (H) incorporated with an aluminium oxide polymer composite. NaOH is used to change the physical aspects of both plant fibres. A total of 20 specimens were tested with varying stacking sequences and padding weight ratios. Mechanical properties like a nanocomposite’s tension, bending, and ILSS was measured. Stacked series and flowability substantially impact the nanocomposite. The Group 3 nanocomposite with 2% Al2O3 has the highest tensile strength, 54.28% of the Group 1 and 2 combinations. The stack series significantly influences the material properties of nanomaterials. Because of the alternating layers of natural fabrics, Group 4 specimens have the maximum flexural strength. Group 3 composite materials have the highest ILSS because they have hemp on the outermost surface. It has been discovered that Group 4 material with a 2% Al2O3 concentration is possibly the most substantial material. The existence of Al2O3 nanoparticles in the green synthesis was confirmed by XRD analysis.
Biosynthesis of Iron Oxide Nanoparticles Using Leaf Extract of Ruellia tuberosa: Mechanical and Dynamic Mechanical Behaviour Kevlar-Based Hybrid Epoxy Composites
One of the more enticing, ecologically responsible, as well as safe and sustainable methodologies is eco-friendly nanomaterial synthesis. Vegetation materials will be used as reductants instead of toxic substances for synthesising nanoparticles. The current study used Ruellia tuberosa (RT) leaf extract digest to synthesise FeO nanomaterials, which were then characterised using XRD. Following that, microbially produced FeO molecules were mixed with a Kevlar-based polymeric matrix to study the blended consequences. To examine the interbreeding, the current experimental analyses were performed, including both static and dynamic mechanical characteristics. The addition of FeO nanofillers improved the elastic modulus, tensile strength, and storage modulus of the nanocomposite. Impact force uptake has been raised to a certain extent by the addition of nanoparticles. The findings of this research show that incorporating FeO nanofillers into Kevlar fabrics is a promising technique for increasing the mechanical characteristics of hybrid laminated composites. As per DMA evaluation, the sample without nanomaterials had a more volcanic lava response, which is a useful thing for body systems for missile use. Another critical aspect of a nanoparticles-filled nanocomposite that must be addressed is the relatively uniform scattering of padding as well as the development of interfacial adhesion in such a combination. The presence of FeO fillers in polymeric composites is confirmed by XRD analysis.
5-Fluorouracil-Loaded PLGA Nanoparticles: Formulation, Physicochemical Characterisation, and In VitroAnti-Cancer Activity
The major goal of this investigation was to prepare a drug delivery of polymeric nanoparticles (NPs) from 5-fluorouracil (FU) that could be delivered intravenously and improve the therapeutic index of the FU. In order to achieve this, interfacial deposition method was used to prepare FU entrapped poly-(lactic-co-glycolic acid) nanoparticles (FU-PLGA-NPs). The influence of various experimental settings on the effectiveness of FU integration into the NPs was assessed. Our findings show that the technique used to prepare the organic phase and the ratio of the organic phase to the aqueous phase had the greatest impact on the effectiveness of FU integration into NPs. The results show that the preparation process produced spherical, homogenous, negatively charged particles with a nanometric size of 200 nm that are acceptable for intravenous delivery. A quick initial release over 24 h and then slow and steady release of FU from the formed NPs, exhibiting a biphasic pattern. Through the human small cell lung cancer cell line (NCI-H69), the in vitro anti-cancer potential of the FU-PLGA-NPs was evaluated. It was then associated to the in vitro anti-cancer potential of the marketed formulation Fluracil®. Investigations were also conducted into Cremophor-EL (Cre-EL) potential activity on live cells. The viability of NCI-H69 cells was drastically reduced when they were exposed to 50 µg·mL−1 Fluracil®. Our findings show that the integration of FU in NPs significantly increases the drug cytotoxic effect in comparison to Fluracil®, with this potential effect being particularly important for extended incubation durations.
Bioinorganic Nanoparticles for the Remediation of Environmental Pollution: Critical Appraisal and Potential Avenues
Nowadays, environmental pollution has become a critical issue for both developed and developing countries. Because of excessive industrialization, burning of fossil fuels, mining and exploration, extensive agricultural activities, and plastics, the environment is being contaminated rapidly through soil, air, and water. There are a variety of approaches for treating environmental toxins, but each has its own set of restrictions. As a result, various therapies are accessible, and approaches that are effective, long-lasting, less harmful, and have a superior outcome are extensively demanded. Modern research advances focus more on polymer-based nanoparticles, which are frequently used in drug design, drug delivery systems, environmental remediation, power storage, transformations, and other fields. Bioinorganic nanomaterials could be a better candidate to control contaminants in the environment. In this article, we focused on their synthesis, characterization, photocatalytic process, and contributions to environmental remediation against numerous ecological hazards. In this review article, we also tried to explore their recent advancements and futuristic contributions to control and prevent various pollutants in the environment.
Optimization of Precious Metals Recovery from Electronic Waste by Chromobacterium violaceum Using Response Surface Methodology (RSM)
An effective recovery technology will be valuable in the future because the concentration of the precious metal contained in the source can be a key driver in recycling technology. This study aims to use response surface methodology (RSM) through Minitab software to discover the optimum oxygen level (mgL−1), e-waste pulp density (% w/v), and glycine concentration (mgL−1) for the maximum recovery of gold (Au) and silver (Ag). The method of precious metals recovery used for this study was taken from the bioleaching using 2 L of batch stirred tank reactor (BSTR). A Box-Behnken of RSM experimental statistical designs was used to optimize the experimental procedure. The result of the RSM optimization showed that the highest recovery was achieved at an oxygen concentration of 0.56 mgL−1, a pulp density of 1.95%, and a glycine concentration of 2.49 mgL−1, which resulted in the recovery of 62.40% of Au. The pulp density and glycine concentration greatly impact how much Au is bioleached by C. violaceum. As a result, not all of the variables analyzed seem crucial for getting the best precious metals recovery, and some adjustments may be useful in the future.