Bioinorganic Chemistry and Applications
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Acceptance rate31%
Submission to final decision59 days
Acceptance to publication24 days
CiteScore9.600
Journal Citation Indicator1.050
Impact Factor4.724

Article of the Year 2021

Nanoparticles for Oral Cancer Diagnosis and Therapy

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 Journal profile

Bioinorganic Chemistry and Applications publishes research in all aspects of bioinorganic chemistry, including bioorganometallic chemistry and applied bioinorganic chemistry, and applications in fields such as medicine and immunology.

 Editor spotlight

Chief Editor, Professor Fanizzi, is based at the Università del Salento. His research interests and current projects are related to the study of transition metals (Platinum in particular), coordination organometallic and bioinorganic chemistry, and the applications of high field NMR Spectroscopy.

 Special Issues

We currently have a number of Special Issues open for submission. Special Issues highlight emerging areas of research within a field, or provide a venue for a deeper investigation into an existing research area.

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Research Article

Green Synthesis of Silver Nanoparticles Using Thespesia populnea Bark Extract for Efficient Removal of Methylene Blue (MB) Degradation via Photocatalysis with Antimicrobial Activity and for Anticancer Activity

The green synthesis method was used to effectively fabricate Ag-NPs by using Thespesia populnea bark extract. The structural, morphological, elemental composition, and optical properties of as-synthesized Ag-NPs were characterized by powder X-ray diffraction (P-XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDAX), transmission electron microscopy (TEM), and UV-Vis spectroscopy. Their photocatalytic efficiency as a photocatalyst was examined by degradation of methylene blue (MB) dye under direct sunlight irradiation. After 120 minutes of sunlight irradiation, Ag-NPs show photocatalytic degradation efficiency (DE percent) of 92%. The hydroxyl and superoxide radicals were found to be responsible for biodegradation. To the best of our acquaintance, this is the first research to use Ag-NPs as a photocatalyst for the efficient degradation of MB dye and its antimicrobial activity by using Thespesia populnea bark extract. The cytotoxic viability against SK-MEL cell line with a median inhibitory concentration (IC50) of 45 μL/mg proved its potent anticancer property. Based on the findings, the study revealed the significance of as-synthesized green Ag-NPs over other physically/chemically prepared Ag-NPs.

Research Article

Effect of Cu Doping on ZnO Nanoparticles as a Photocatalyst for the Removal of Organic Wastewater

Environmental problems with chemical and biological water pollution have become a major concern for society. Providing people with safe and affordable water is a grand challenge of the 21st century. The study investigates the photocatalytic degradation capabilities of hydrothermally prepared pure and Cu-doped ZnO nanoparticles (NPs) for the elimination of dye pollutants. A simple, cost-effective hydrothermal process is employed to synthesize the Cu-doped ZnO NPs. The photocatalytic dye degradation activity of the synthesized Cu-doped ZnO NPs is tested by using methylene blue (MB) dye. In addition, the parameters that affect photodegradation efficiency, such as catalyst concentration, starting potential of hydrogen (pH), and dye concentration, were also assessed. The dye degradation is found to be directly proportional to the irradiation time, as 94% of the MB dye is degraded in 2 hrs. Similarly, the dye degradation shows an inverse relation to the MB dye concentration, as the degradation reduced from 94% to 20% when the MB concentration increases from 5 ppm to 80 ppm. The synthesized cost-effective and environmentally friendly Cu-doped ZnO NPs exhibit improved photocatalytic activity against MB dye and can therefore be employed in wastewater treatment materials.

Research Article

Cross-Disciplinary Application for Qualitative Magnesium Corrosion Assays

At the moment, unserviceable magnesium implants make a good case in point for further responsible study in this field. Whether we are willing to admit it or not, existing methods for corrosion monitoring are exposed to susceptibility and instability. Interdisciplinary theories and the existing corrosion experiments were combined based on their various merits for developing an accurate and precise corroding experiment for Mg/Mg alloys. We used the water-soluble tetrazolium-8 (WST-8) reagent to further complete the immersion experiment. The color change of the solution reflects the rationale of corrosion, followed by monitoring the degree of corrosion. The feasibility of this idea will be demonstrated.

Research Article

Synthesis, Characterization, PXRD Studies, Theoretical Calculation, and Antitumor Potency Studies of a Novel N,O-Multidentate Chelating Ligand and Its Zr(IV), V(IV), Ru(III), and Cd(II) Complexes

A new series of Zr(IV), V(IV), Ru(III), and Cd(II) complexes with the ligand N-((5-hydroxy-4-oxo-4H-pyran-3-yl)methylene)-2-(p-tolylamino)acetohydrazide (H2L) have been prepared. FT-IR, 1H-NMR, electronic spectra, powder X-ray, and thermal behavior methods were applied to elucidate the structural composition of new compounds. Geometry optimization for all synthesized compounds was conducted using the Gaussian09 program via the DFT method, to obtain optimal structures and essential parameters. Moreover, the antibacterial and antitumor activity of the ligand and its complexes were studied, where the Cd(II) complex acquires probably the best antibacterial activity followed by the Ru(III) complex towards bacterial species than others when using ampicillin and gentamicin were used as standard drugs. The complexes exhibited interestingly antitumor potential against the MCF-7 breast cancer cell line. The cytotoxicity of the new complexes has been arranged to follow the order: Ru(III) complex > Cd(II) complex > Zr(IV) complex > V(IV) complex > ligand. Molecular docking was performed on the active site of ribosyltransferase and obtained good results. Structure-based molecular docking is used to identify a potential therapeutic inhibitor for NUDT5.

Research Article

Development Mode of Recreation Belt around the City: Ecological Authenticity or Fashion Creativity?

The recreational belt around the city has low population density, good ecological environment, and rich natural and cultural landscapes, which can meet the tourism needs of urban residents to get close to nature and experience culture. Particularly in today’s increasingly normal epidemic prevention and control, outing and microtourism have become the first choice of urban public tourism and an important part of rural tourism development. In the process of developing rural tourism, there are two distinct voices: one is to pay attention to the local complex and strive to let people “see mountains and water and remember nostalgia.” In the era of cultural tourism integration, we should promote rural tourism with culture, highlight rural culture with rural tourism, and give full play to the bridge between cultural tourism and rural cultural innovation. In view of this situation, this paper discusses the theme orientation of the advanced development of the recreational belt around the city through three studies. In Study 1, tourists’ perceptions of local complex and rural cultural creation were compared through field investigation. In Study 2, brand trust was used as a calibration variable to further test the robustness of the conclusion. Study 3 analyzed the “distortion” mechanism of rural cultural creation and tested the intermediary effect of psychological distance. At the same time, it discusses the evolution model of the recreational space system around the city. The development of recreation space shows that the recreation space around the city is the product of the agglomeration of population and economic activities, and its occurrence and development process is closely related to the expansion of urban space and the change of human living space. This paper analyzes the spatial process of the development of recreation around the city, focuses on the types of recreation space that continue to appear in the development and evolution of modern recreation space, and then tries to find the context of the gradual development and evolution of recreation around the city with the process of urbanization and excavate the organic connection between the recreational space and the city and its surrounding areas in the process of development and evolution. It is found that (1) tourists’ perception of local culture is further distorted, which leads to a further reduction in tourists’ perception of “local culture” and “recreation,” and (2) the increase in psychological distance is the key psychological mechanism for tourists to perceive “lost property.”

Research Article

Preparation of an Intelligent pH Film Based on Biodegradable Polymers for Monitoring the Food Quality and Reducing the Microbial Contaminants

Hydrogel refers to a three-dimensional cross-linked polymeric network made of synthetic or natural polymers that can hold water in its porous structure. The inclusion of hydrophilic groups in the polymer chains, such as amino, carboxyl, and hydroxyl groups, contributes to the hydrogel’s water-holding ability. At physiological temperature and pH, these polymeric materials do not dissolve in water, but they do swell significantly in aqueous media. Hydrogel can be manufactured out of almost any water-soluble polymer, and it comes in a variety of chemical compositions and bulk physical properties. Hydrogel can also be made in a variety of ways. Hydrogel comes in a variety of physical shapes, including slabs, microparticles, nanoparticles, coatings, and films. Due to its ease of manufacture and self-application in clinical and fundamental applications, hydrogel has been widely exploited as a drug carrier. Contact lenses, artificial corneas, wound dressing, suture coating, catheters, and electrode sensors are some of the biomedical applications of hydrogels. The pigment color changes were observed from colorless to pale pink followed by dark reddish-pink. Anthocyanin was produced in large quantities and tested using a UV-visible spectrophotometer. At 450–550 nm, the largest peak (absorbance) was detected, indicating the presence of anthocyanin. The FTIR analysis of this study shows the different stretches of bonds at different peaks: 2918.309 (-C-H alkane stretch), 2812.12 (-C-H aldehyde weak intensity), 192320.37/cm (C-O bend), 21915.50, 2029.08/cm (-C=C arene group), 1906.94/cm (=C-H aromatics), 1797.78/cm (=C-H), 1707.94 (-C=O ketene), 1579.70, 1382.96 (C-H alkane strong bend), 889.18/cm (C-H aromatics plane bend), and 412.77/cm (-C-CI strong bond). The spectra of the PVA/chitosan film depict the peak’s formation: 1571.88, 1529.55, 1500.62/cm (C-H alkene strong bend), 1492.90, 1483.26, 1467.83/cm (C-H alkene strong bond), 670.48, 443.63, 412.77/cm (-O-H carboxylic acids with great intensity), 1708.93 (-C=O ketone), and 1656.0/cm (alkenyl C=C stretch strong bond).

Bioinorganic Chemistry and Applications
 Journal metrics
See full report
Acceptance rate31%
Submission to final decision59 days
Acceptance to publication24 days
CiteScore9.600
Journal Citation Indicator1.050
Impact Factor4.724
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Article of the Year Award: Outstanding research contributions of 2021, as selected by our Chief Editors. Read the winning articles.