7th International Symposium on Applied Bioinorganic Chemistry Guanajuato, Mexico, April 2003View this Special Issue
A. Myari, N. Hadjiliadis, A. Garoufis, "1H NMR Study of the Enantioselective Binding of - and -[Ru(bpy)2(m-bpy-GHK)]Cl2 to the Deoxynucleotide Duplex d(5'-C1G2C3G4A5A6T7T8C9G10C11G12-3')2", Bioinorganic Chemistry and Applications, vol. 3, Article ID 765234, 9 pages, 2005. https://doi.org/10.1155/BCA.2005.109
1H NMR Study of the Enantioselective Binding of - and -[Ru(bpy)2(m-bpy-GHK)]Cl2 to the Deoxynucleotide Duplex d(5'-C1G2C3G4A5A6T7T8C9G10C11G12-3')2
The interaction of the diastereomeric complexes Λ- and , (GHK = glycine-histidine-lysine) to the deoxynucleotide duplex d(5'-CGCGAATTCGCG-3')2 was studied by means of 1H NMR spectroscopy. The diastereomers interact with the oligonucleotide duplex differently. The is characterized by major groove binding close to the central part of the oligonucleotide, with both the peptide and the bipyridine ligand of the complex involved in the binding. The binds loosely, approaching the helix from the minor groove. The NMR analysis shows that the peptide (GHK) binding has a determinative role in the interactions of both diastereomers with the oligonucleotide.
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