Synthesis, Spectroscopic and Physicochemical Characterization and Biological Activity of Co(II) and Ni(II) Coordination Compounds with 4-Aminoantipyrine Thiosemicarbazone

Abstract

We describe the synthesis and characterization of cobalt(II) and nickel(II) coordination compounds of 4[N-(furan-2’-aldimine)amino]antipyrine thiosemicarbazone (FFAAPTS) and 4[N-(4'-nitrobenzalidene) amino]antipyrine thiosemicarbazone (4'-NO₂BAAPTS). All the isolated compounds have the general composition MX₂(L)(H₂O) (M = Co²⁺ or Ni²⁺; X = Cl, Br, NO₃, NCS or CH₃COO; L = FFAAPTS or 4'-NO₂BAAPTS) and M(ClO₄)₂(L)₂ (M = Co²⁺ or Ni²⁺; L = FFAAPTS or 4'-NO₂BAAPTS). Infrared spectral studies indicate that both the thiosemicarbazones coordinate in their neutral form and they act as {N,N,S} tridentate chelating ligands. Room temperature magnetic measurements and electronic spectral studies suggest the distorted octahedral geometries of the prepared complexes. Thermogravimetric studies are also reported and the possible structures of the complexes are proposed. Antibacterial and antifungal properties of these metal-coordination compounds have also been studied.