Protective Effect of <i>Meso</i>-Tetrakis-(3,5-di-<i>tert</i>- butyl-4-hydroxyphenyl)porphyrin on the In Vivo Impact of Trimethyltin Chloride on the Antioxidative Defense System

Milaeva, Elena R.; Tyurin, Vladimir Yu.; Gracheva, Yulia A.; Dodochova, Margarita A.; Pustovalova, Lydia M.; Chernyshev, Victor N.

doi:https://doi.org/10.1155/BCA/2006/64927

Bioinorganic Chemistry and Applications

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Volume 2006 | Article ID 064927 | https://doi.org/10.1155/BCA/2006/64927

Protective Effect of Meso-Tetrakis-(3,5-di-tert- butyl-4-hydroxyphenyl)porphyrin on the In Vivo Impact of Trimethyltin Chloride on the Antioxidative Defense System

Elena R. Milaeva,¹Vladimir Yu. Tyurin,¹Yulia A. Gracheva,¹Margarita A. Dodochova,²Lydia M. Pustovalova,²and Victor N. Chernyshev²

Received19 Jun 2006

Revised15 Aug 2006

Accepted10 Oct 2006

Published27 Dec 2006

Abstract

The in vivo effect of trimethyltin chloride (Me3SnCl), free base meso-tetrakis(3,5-di-tert-butyl-4-hydroxyphenyl)porphyrin (R′4PH2) and their equimolar mixture, on the enzymatic activity of catalase (CAT), superoxide dismutase (SOD), and on the total content of free sulfhydryl groups has been studied in rat liver and kidney. It was demonstrated that the simultaneous treatment of tested animals with the combination of Me3SnCl and R′4PH2 reduced the toxic impact of Me3SnCl.

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Copyright © 2006 Elena R. Milaeva et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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