Regioselective Synthesis of <em>Bis</em>(2-halo-3-pyridyl) Dichalcogenides (E = S, Se and Te): Directed Ortho-Lithiation of 2-halopyridines

Bhasin, K. K.; Singh, Neelam; Doomra, Shivani; Arora, Ekta; Ram, Ganga; Singh, Sukhjinder; Nagpal, Yogesh; Mehta, S. K.; Klapotke, T. M.

doi:https://doi.org/10.1155/2007/69263

Bioinorganic Chemistry and Applications

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Volume 2007 | Article ID 069263 | https://doi.org/10.1155/2007/69263

Regioselective Synthesis of Bis(2-halo-3-pyridyl) Dichalcogenides (E = S, Se and Te): Directed Ortho-Lithiation of 2-halopyridines

K. K. Bhasin,¹Neelam Singh,²Shivani Doomra,¹Ekta Arora,¹Ganga Ram,¹Sukhjinder Singh,¹Yogesh Nagpal,¹S. K. Mehta,¹and T. M. Klapotke³

Academic Editor: Govindasamy Mugesh

Received20 Jul 2006

Revised26 Dec 2006

Accepted16 Jan 2007

Published25 Mar 2007

Abstract

A novel method for the preparation of hitherto unknown symmetrical bis(2-halo-3-pyridyl) dichalcogenides (E = S, Se and Te) by the oxidation of intermediate 2-halo-3-pyridyl chalcogenolate, prepared by lithiation of 2-halo pyridines using lithium diisopropylamine is being reported. All the newly synthesized compounds have been characterized through elemental analysis employing various spectroscopic techniques, namely, NMR (H1, C13, S77e), infrared, mass spectrometry, and X-ray crystal structures in representative cases.

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Copyright © 2007 K. K. Bhasin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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