Table of Contents Author Guidelines Submit a Manuscript
Bioinorganic Chemistry and Applications
Volume 2007, Article ID 98732, 15 pages
http://dx.doi.org/10.1155/2007/98732
Research Article

Complexes of Pd(II) and Pt(II) with 9-Aminoacridine: Reactions with DNA and Study of Their Antiproliferative Activity

1Departamento de Química Inorgànica, Facultat de Química, Universitat de Barcelona, Martí i Franquès 1-11, Barcelona 08028, Spain
2Departamento de Bioquímica i Biologia Molecular, Facultat de Biología, Universitat de Barcelona, avenue Diagonal 645, Barcelona 08028, Spain
3Departamento de Cristal.lografia, Mineralogia i Dipòsits Minerals, Facultat de Geología, Universitat de Barcelona, C/ Martí i Franquès s/n, Barcelona 08028, Spain

Received 16 March 2007; Accepted 10 May 2007

Academic Editor: Giovanni Natile

Copyright © 2007 X. Riera et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [32 citations]

The following is the list of published articles that have cited the current article.

  • Jose Ruiz, Julia Lorenzo, Consuelo Vicente, Gregorio Lopez, Jose Maria Lopez-de-Luzuriaga, Miguel Monge, Francesc X. Aviles, Delia Bautista, Virtudes Moreno, and Antonio Laguna, “New palladium(II) and platinum(II) complexes with 9-aminoacridine: Structures, luminiscence, theoretical calculations, and antitumor activity,” Inorganic Chemistry, vol. 47, no. 15, pp. 6990–7001, 2008. View at Publisher · View at Google Scholar
  • A. Garoufis, S.K. Hadjikakou, and N. Hadjiliadis, “Palladium coordination compounds as anti-viral, anti-fungal, anti-microbial and anti-tumor agents,” Coordination Chemistry Reviews, vol. 253, no. 9-10, pp. 1384–1397, 2009. View at Publisher · View at Google Scholar
  • M. Helena Garcia, Tania S. Morais, Pedro Florindo, M. Fatima M. Piedade, Virtudes Moreno, Carlos Ciudad, and Veronica Noe, “Inhibition of cancer cell growth by ruthenium(II) cyclopentadienyl derivative complexes with heteroaromatic ligands,” Journal Of Inorganic Biochemistry, vol. 103, no. 3, pp. 354–361, 2009. View at Publisher · View at Google Scholar
  • Natalia Miklášová, Eva Fischer-Fodor, Peter Lönnecke, Maria Perde Schrepler, Piroska Virag, Corina Tatomir, Valentin Ioan Cernea, Evamarie Hey-Hawkins, and Luminita Silaghi-Dumitrescu, “Antiproliferative effect and genotoxicity of novel synthesized palladium complexes with organoarsenic ligands,” Journal of Inorganic Biochemistry, vol. 103, no. 12, pp. 1739–1747, 2009. View at Publisher · View at Google Scholar
  • N. A. Kas'yanenko, E. V. Levykina, O. S. Erofeeva, N. A. Ivanova, and I. A. Efimenko, “Effects of palladium acido complexes [L (n) ] (m) [PdX4] on the conformation of DNA in vitro,” Journal Of Structural Chemistry, vol. 50, no. 5, pp. 996–1006, 2009. View at Publisher · View at Google Scholar
  • Julio Benitez, Lucia Guggeri, Isabel Tomaz, Joao Costa Pessoa, Virtudes Moreno, Julia Lorenzo, Francesc X. Aviles, Beatriz Garat, and Dinorah Gambino, “A novel vanadyl complex with a polypyridyl DNA intercalator as ligand: A potential anti-protozoa and anti-tumor agent,” Journal Of Inorganic Biochemistry, vol. 103, no. 10, pp. 1386–1394, 2009. View at Publisher · View at Google Scholar
  • José Ruiz, Consuelo Vicente, Concepción de Haro, and Delia Bautista, “A novel ruthenium(ii) arene based intercalator with potent anticancer activity,” Dalton Transactions, no. 26, pp. 5071, 2009. View at Publisher · View at Google Scholar
  • Burcu Turanli-Yildiz, Tugba Sezgin, Z. Petek Çakar, Canan Uslan, B. Sebnem Sesalan, and Ahmet Gül, “The use of novel photobleachable phthalocyanines to image DNA,” Synthetic Metals, vol. 161, no. 15-16, pp. 1720–1724, 2011. View at Publisher · View at Google Scholar
  • Virtudes Moreno, Mercè Font-Bardia, Teresa Calvet, Julia Lorenzo, Francesc X. Avilés, M. Helena Garcia, Tânia S. Morais, Andreia Valente, and M. Paula Robalo, “DNA interaction and cytotoxicity studies of new ruthenium(II) cyclopentadienyl derivative complexes containing heteroaromatic ligands,” Journal of Inorganic Biochemistry, vol. 105, no. 2, pp. 241–249, 2011. View at Publisher · View at Google Scholar
  • Mihaela Badea, Elica Iosub, Carmen Mariana Chifiriuc, Luminita Marutescu, Emilia Elena Iorgulescu, Veronica Lazar, Dana Marinescu, Coralia Bleotu, and Rodica Olar, “Thermal, spectral, electrochemical and biologic characterization of new Pd(II) complexes with ligands bearing biguanide moieties,” Journal of Thermal Analysis and Calorimetry, vol. 111, no. 3, pp. 1753–1761, 2012. View at Publisher · View at Google Scholar
  • Ana Isabel Tomaz, Tamás Jakusch, Tânia S. Morais, Fernanda Marques, Rodrigo F.M. de Almeida, Filipa Mendes, Éva A. Enyedy, Isabel Santos, João Costa Pessoa, Tamás Kiss, and M. Helena Garcia, “[RuII(η5-C5H5)(bipy)(PPh3)]+, a promising large spectrum antitumor agent: Cytotoxic activity and interaction with human serum albumin,” Journal of Inorganic Biochemistry, vol. 117, pp. 261–269, 2012. View at Publisher · View at Google Scholar
  • Hanaa A. El-Boraey, “Coordination behavior of tetraaza [N4] ligand towards Co(II), Ni(II), Cu(II), Cu(I) and Pd(II) complexes: Synthesis, spectroscopic characterization and anticancer activity,” Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, vol. 97, pp. 255–262, 2012. View at Publisher · View at Google Scholar
  • Maria Tomé, Concepción López, Asensio González, Bahadir Ozay, Josefina Quirante, Mercè Font-Bardía, Teresa Calvet, Carme Calvis, Ramon Messeguer, Laura Baldomá, and Josefa Badía, “Trans- and cis-2-phenylindole platinum(II) complexes as cytotoxic agents against human breast adenocarcinoma cell lines,” Journal of Molecular Structure, vol. 1048, pp. 88–97, 2013. View at Publisher · View at Google Scholar
  • Zohreh Derikvand, Marilyn M. Olmstead, Brandon Q. Mercado, Ardeshir Shokrollahi, and Mehdi Shahriyari, “Solid and solution states studies of three new supramolecular compounds of zinc(II), nickel(II) and uranyl(VI) with chelidamic acid and 9-aminoacridine,” Inorganica Chimica Acta, 2013. View at Publisher · View at Google Scholar
  • Daniel Talancón, Concepción López, Mercè Font-Bardía, Teresa Calvet, Josefina Quirante, Carme Calvis, Ramon Messeguer, Roldán Cortés, Marta Cascante, Laura Baldomà, and Josefa Badia, “Diastereomerically pure platinum(II) complexes as antitumoral agents.,” Journal of Inorganic Biochemistry, vol. 118, pp. 1–12, 2013. View at Publisher · View at Google Scholar
  • Joan Albert, Silvia Garcia, Jaume Granell, Albert Llorca, Maria Victoria Lovelle, Virtudes Moreno, Andreu Presa, Laura Rodriguez, Josefina Quirante, Carme Calvis, Ramon Messeguer, Josefa Badia, and Laura Baldoma, “Cyclopalladated benzophenone imines: Synthesis, cytotoxicity against human breast adenocarcinoma cell lines and DNA interaction,” Journal Of Organometallic Chemistry, vol. 724, pp. 289–296, 2013. View at Publisher · View at Google Scholar
  • Andreia Valente, Ana Margarida Santos, Leonor Côrte-Real, M. Paula Robalo, Virtudes Moreno, Mercè Font-Bardia, Teresa Calvet, Julia Lorenzo, and M. Helena Garcia, “New iron(II) cyclopentadienyl derivative complexes: synthesis and antitumor activity against human leukemia cancer cells,” Journal of Organometallic Chemistry, 2014. View at Publisher · View at Google Scholar
  • Eva Fischer-Fodor, Ana-Maria Vălean, Piroska Virag, Petru Ilea, Corina Tatomir, Florica Imre-Lucaci, Maria Perde Schrepler, Ludovic Tibor Krausz, Lucian Barbu Tudoran, Calin George Precup, Iulia Lupan, Evamarie Hey-Hawkins, and Luminita Silaghi-Dumitrescu, “Gallium phosphinoarylbisthiolato complexes counteract drug resistance of cancer cells,” Metallomics, vol. 6, no. 4, pp. 833, 2014. View at Publisher · View at Google Scholar
  • Nadia El-wakiel, Mai El-keiy, and Mohamed Gaber, “Synthesis, spectral, antitumor, antioxidant and antimicrobial studies on Cu(II), Ni(II) and Co(II) complexes of 4-[(1H-Benzoimidazol-2-ylimino)-methyl]-benzene-1,3-diol,” Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, vol. 147, pp. 117–123, 2015. View at Publisher · View at Google Scholar
  • Helena Guiset Miserachs, Micaella Cipriani, Jordi Grau, Marta Vilaseca, Julia Lorenzo, Andrea Medeiros, Marcelo A. Comini, Dinorah Gambino, Lucía Otero, and Virtudes Moreno, “Antitumor and antiparasitic activity of novel ruthenium compounds with polycyclic aromatic ligands,” Journal of Inorganic Biochemistry, 2015. View at Publisher · View at Google Scholar
  • P. Banerjee, P. Majumder, S. Halder, M. G. B. Drew, S. Bhattacharya, and S. Mazumder, “Comparative anti-proliferative activity of some new 2-(arylazo)phenolate–palladium (II) complexes and cisplatin against some human cancer cell lines,” Free Radical Research, pp. 1–16, 2015. View at Publisher · View at Google Scholar
  • Leila Tabrizi, and Hossein Chiniforoshan, “New water-soluble palladium(II) complexes of lidocaine and phenylcyanamide derivative ligands: cytotoxicity and cellular response mechanisms,” Investigational New Drugs, 2016. View at Publisher · View at Google Scholar
  • Md Nur Alam, and Fazlul Huq, “Comprehensive review on tumour active palladium compounds and structure-activity relationships,” Coordination Chemistry Reviews, 2016. View at Publisher · View at Google Scholar
  • Barbara Mavroidi, Marina Sagnou, Kostas Stamatakis, Maria Paravatou-Petsotas, Maria Pelecanou, and Constantinos Methenitis, “Palladium(II) and platinum(II) complexes of derivatives of 2-(4’ aminophenyl)benzothiazole as potential anticancer agents,” Inorganica Chimica Acta, 2016. View at Publisher · View at Google Scholar
  • Ehsan Zareian Jahromi, Adeleh Divsalar, Ali Akbar Saboury, Sara Khaleghizadeh, Hassan Mansouri-Torshizi, and Irena Kostova, “Palladium complexes: new candidates for anti-cancer drugs,” Journal of the Iranian Chemical Society, 2016. View at Publisher · View at Google Scholar
  • A.M. Nassar, “Bioactive Palladium azomethine chelates, a review of recent research,” Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry, pp. 00–00, 2016. View at Publisher · View at Google Scholar
  • Fawaz A. Saad, Jabir H. Al-Fahemi, Hoda El-Ghamry, Abdalla M. Khedr, Marwa G. Elghalban, and Nashwa M. El-Metwaly, “Elaborated spectral, modeling, QSAR, docking, thermal, antimicrobial and anticancer activity studies for new nanosized metal ion complexes derived from sulfamerazine azodye,” Journal of Thermal Analysis and Calorimetry, 2017. View at Publisher · View at Google Scholar
  • Mohamed Gaber, Hoda A. El-Ghamry, and Mohamed A. Mansour, “Pd(II) and Pt(II) chalcone complexes. Synthesis, spectral characterization, molecular modeling, biomolecular docking, antimicrobial and antitumor activities,” Journal of Photochemistry and Photobiology A: Chemistry, 2017. View at Publisher · View at Google Scholar
  • Sanaa M. Emam, Ibrahim E.T. El Sayed, Mohamed I. Ayad, and Heba M. Hathout, “Synthesis, characterization and anticancer activity of new Schiff bases bearing neocryptolepine,” Journal of Molecular Structure, 2017. View at Publisher · View at Google Scholar
  • Fawaz A. Saad, and Abdalla M. Khedr, “Greener solid state synthesis of nano-sized mono and homo bi-nuclear Ni(II), Co(II), Mn(II), Hg(II), Cd(II) and Zn(II) complexes with new sulfa ligand as a potential antitumour and antimicrobial agents,” Journal of Molecular Liquids, 2017. View at Publisher · View at Google Scholar
  • M Ángeles Martínez, M. Pilar Carranza, Anna Massaguer, Lucia Santos, Juan A. Organero, Cristina Aliende, Rafael de Llorens, Iteng Ng-Choi, Lidia Feliu, Marta Planas, Ana M. Rodríguez, Blanca R. Manzano, Gustavo Espino, and Félix A. Jalón, “Synthesis and Biological Evaluation of Ru(II) and Pt(II) Complexes Bearing Carboxyl Groups as Potential Anticancer Targeted Drugs,” Inorganic Chemistry, 2017. View at Publisher · View at Google Scholar
  • Jabir H. Al-Fahemi, Abdalla M. Khedr, Ismail Althagafi, Nashwa M. El-Metwaly, Fawaz A. Saad, and Hanadi A. Katouah, “Green synthesis approach for novel benzenesulfonamide nanometer complexes with elaborated spectral, theoretical and biological treatments,” Applied Organometallic Chemistry, pp. e4460, 2018. View at Publisher · View at Google Scholar