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Bioinorganic Chemistry and Applications
Volume 2008, Article ID 436458, 7 pages
Research Article

Synthesis and Antimicrobial Activity of Silver Citrate Complexes

Elchem Consulting Ltd., Edmonton, AB, Canada T5X 6B3

Received 1 September 2008; Accepted 6 October 2008

Academic Editor: Ming Yang

Copyright © 2008 Stojan Djokić. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Formation of silver citrate/citric acid complexed solutions was investigated. Although, silver citrate is minimally soluble in water, it can successfully be dissolved in citric acid solutions. The maximum concentration of Ag(I) in solution is estimated at 23 to 25 g/L if the concentration of citric acid is at least 4 mol/L or higher. The dissolution of silver citrate in citric acid solutions was attributed to the formation of silver citrate complexes of a general formula [Ag3(C6H5O7)𝑛+1]3𝑛−. The silver citrate/citric acid solutions, containing more than about 13 g/L Ag+ ion, have exhibited a decrease in Ag(I) concentration in solution over time, due to crystallization. The crystallization product was attributed to the formation of [Ag3C6H5O7]𝑥⋅𝑛H2O. Importantly, the diluted silver citrate/citric acid complexed solutions have exhibited very strong bacteriostatic and bactericidal activities.