Synthesis, Characterization, and Biological Activity Studies of Copper(II) Mixed Compound with Histamine and Nalidixic Acid

Scheme 1

Synthesis, characterization and crystal structure of a copper(II) mixed complex with histamine and nalidixic acid, a compound of the quinolone family, [Cu(hsm)(nal)H₂O]Cl∙3H₂O is reported. Biological studies performed with this compound revealed that it interacts with DNA in vivo inducing the SOB response on Bacillus subtilis, however nuclease activity is not observed in vitro experiments