Synthesis, Characterization, and Biological Activity Studies of Copper(II) Mixed Compound with Histamine and Nalidixic Acid

Table 2

Expermental melting temperatures (Tm) and difference with the CT-DNA Tm (ΔTm) values as determined from the thermal denaturation profiles of CT-DNA and its interactions with the [Cu(hsm)(nal)H₂O]Cl⋅3H₂O or [Cu(phen)(nal)H₂O]NO₃⋅3H₂O complexes.

	[Cu(hsm)(nal)H2O]Cl⋅3H2O /CT-DNA		[Cu(phen)(nal)H2O]NO3⋅3H2O /CT-DNA
r	Tm (°C)	ΔTm	Tm (°C)	ΔTm
0.0	82.7	—	82.7	—
0.096	83.5	0.8	83.4	0.7
0.28	84.9	2.2
0.48	84.6	1.9	87.5	4.8
0.77	86	3.3	83.7	1
0.96	86.9	4.2