Synthesis, Novel Crystal Structure, and <svg style="vertical-align:-4.698pt;width:13.15px;" id="M1" height="21.9375" version="1.1" viewBox="0 0 13.15 21.9375" width="13.15" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg"><g transform="matrix(.022,-0,0,-.022,.062,16.025)"><path id="x1D6FD" d="M558 587q0 -32 -14 -61t-40 -53.5t-48.5 -41t-54.5 -36.5q144 -51 144 -174q0 -55 -43.5 -108t-104.5 -87q-77 -42 -131 -42q-31 0 -54 20t-31 47l11 18q48 -29 108 -29q79 0 119.5 43t40.5 109t-44.5 107.5t-119.5 50.5l22 47q34 1 65 21q96 61 96 157q0 42 -24 67.5
t-62 25.5q-24 0 -43.5 -9t-35 -29.5t-27 -44t-22.5 -63t-19.5 -75.5t-18.5 -91q-57 -294 -68 -380q-26 -190 -35 -200q-26 -31 -97 -37l-4 26q19 9 48 170l77 413q23 121 52.5 187.5t83.5 114.5q70 62 148 62q51 0 88.5 -34t37.5 -91z" /></g></svg>-Amyloid Binding Property of Re(I) <svg style="vertical-align:-4.62599pt;width:125px;" id="M2" height="24.3375" version="1.1" viewBox="0 0 125 24.3375" width="125" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg"><g transform="matrix(.022,-0,0,-.022,.062,18.513)"><path id="x28" d="M300 -147l-18 -23q-106 71 -159 185.5t-53 254.5v1q0 139 53 252.5t159 186.5l18 -24q-74 -62 -115.5 -173.5t-41.5 -242.5q0 -130 41.5 -242.5t115.5 -174.5z" /></g><g transform="matrix(.022,-0,0,-.022,7.819,18.513)"><path id="x74" d="M298 36l-68 -35q-25 -13 -42 -13q-98 0 -98 119v290h-69l-4 11l28 29h45v72l65 67l14 -2v-137h113q8 -8 6 -21t-12 -19h-107v-256q0 -96 59 -96q29 0 61 17z" /></g><g transform="matrix(.022,-0,0,-.022,14.745,18.513)"><path id="x72" d="M181 342h2q63 107 121 107q24 0 41 -16t17 -34q0 -34 -32 -49q-17 -7 -26 2q-21 20 -43 20q-20 0 -42 -22t-38 -63v-183q0 -50 12.5 -62t69.5 -16v-26h-230v26q47 5 58 17t11 61v207q0 49 -9 60.5t-53 16.5v23q74 12 141 40v-109z" /></g><g transform="matrix(.022,-0,0,-.022,23.196,18.513)"><path id="x69" d="M135 536q-20 0 -35 15.5t-15 35.5q0 22 15 37t36 15t35.5 -15t14.5 -37q0 -21 -15 -36t-36 -15zM252 0h-220v26q48 5 59 17t11 63v206q0 47 -9 58t-54 18v24q78 12 142 39v-345q0 -51 11.5 -63t59.5 -17v-26z" /></g><g transform="matrix(.022,-0,0,-.022,29.204,18.513)"><path id="x63" d="M390 111l17 -21q-34 -45 -80 -73.5t-89 -28.5q-91 0 -146 62t-55 147q0 118 101 195q74 57 149 57h1q59 0 90 -27q16 -14 16 -30q0 -15 -12 -29t-21 -14q-8 0 -19 11q-44 41 -101 41q-52 0 -87.5 -42.5t-35.5 -117.5q0 -49 15 -87t39 -58t49 -30t48 -10q33 0 60.5 12
t60.5 43z" /></g><g transform="matrix(.022,-0,0,-.022,38.753,18.513)"><path id="x61" d="M433 39l-85 -51q-27 0 -47 20q-16 16 -24 44q-5 -3 -24 -16.5t-27 -18.5t-23 -13.5t-25 -12t-19 -3.5q-52 0 -86 36.5t-34 85.5q0 71 81 99q128 43 155 65v17q0 54 -23 83.5t-62 29.5q-28 0 -45 -19t-29 -66q-7 -23 -29 -23q-15 0 -29 13t-14 30t31 40q25 19 68.5 40.5
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" /></g><g transform="matrix(.022,-0,0,-.022,91.229,18.513)"><path id="x79" d="M478 437v-26q-39 -6 -53 -17.5t-35 -54.5q-12 -24 -26.5 -59.5l-44 -107.5l-55.5 -134q-86 -205 -103 -270q-6 -25 -32 -25q-21 0 -38.5 15t-17.5 33q0 19 25 37q40 24 75 88q18 34 31 69q7 20 -2 45q-67 191 -114 306q-17 43 -31.5 56.5t-54.5 18.5v26h202l1 -26
q-35 -5 -42 -16t4 -39l90 -250q57 137 92 249q10 28 0 39.5t-52 16.5v26h181z" /></g><g transform="matrix(.022,-0,0,-.022,101.653,18.513)"><path id="x6C" d="M238 0h-223v26q48 5 60 17t12 61v473q0 50 -10.5 60.5t-58.5 15.5v24q73 8 148 35v-608q0 -49 11.5 -61t60.5 -17v-26z" /></g><g transform="matrix(.022,-0,0,-.022,107.324,18.513)"><path id="x29" d="M275 270q0 -296 -211 -440l-19 23q75 62 116.5 174t41.5 243t-42 243t-116 173l19 24q211 -144 211 -440z" /></g><g transform="matrix(.016,-0,0,-.016,115.1,7.75)"><path id="x2B" d="M535 230h-212v-233h-58v233h-213v50h213v210h58v-210h212v-50z" /></g></svg> EHIDA Analogue

<table>ORTEP drawing of the Re(CO)<sub>3</sub>(L).</table>

Bioinorganic Chemistry and Applications

fig4

Figure 4

Figure 4: Synthesis, Novel Crystal Structure, and <svg style="vertical-align:-4.698pt;width:13.15px;" id="M1" height="21.9375" version="1.1" viewBox="0 0 13.15 21.9375" width="13.15" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg"><g transform="matrix(.022,-0,0,-.022,.062,16.025)"><path id="x1D6FD" d="M558 587q0 -32 -14 -61t-40 -53.5t-48.5 -41t-54.5 -36.5q144 -51 144 -174q0 -55 -43.5 -108t-104.5 -87q-77 -42 -131 -42q-31 0 -54 20t-31 47l11 18q48 -29 108 -29q79 0 119.5 43t40.5 109t-44.5 107.5t-119.5 50.5l22 47q34 1 65 21q96 61 96 157q0 42 -24 67.5
t-62 25.5q-24 0 -43.5 -9t-35 -29.5t-27 -44t-22.5 -63t-19.5 -75.5t-18.5 -91q-57 -294 -68 -380q-26 -190 -35 -200q-26 -31 -97 -37l-4 26q19 9 48 170l77 413q23 121 52.5 187.5t83.5 114.5q70 62 148 62q51 0 88.5 -34t37.5 -91z" /></g></svg>-Amyloid Binding Property of Re(I) <svg style="vertical-align:-4.62599pt;width:125px;" id="M2" height="24.3375" version="1.1" viewBox="0 0 125 24.3375" width="125" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg"><g transform="matrix(.022,-0,0,-.022,.062,18.513)"><path id="x28" d="M300 -147l-18 -23q-106 71 -159 185.5t-53 254.5v1q0 139 53 252.5t159 186.5l18 -24q-74 -62 -115.5 -173.5t-41.5 -242.5q0 -130 41.5 -242.5t115.5 -174.5z" /></g><g transform="matrix(.022,-0,0,-.022,7.819,18.513)"><path id="x74" d="M298 36l-68 -35q-25 -13 -42 -13q-98 0 -98 119v290h-69l-4 11l28 29h45v72l65 67l14 -2v-137h113q8 -8 6 -21t-12 -19h-107v-256q0 -96 59 -96q29 0 61 17z" /></g><g transform="matrix(.022,-0,0,-.022,14.745,18.513)"><path id="x72" d="M181 342h2q63 107 121 107q24 0 41 -16t17 -34q0 -34 -32 -49q-17 -7 -26 2q-21 20 -43 20q-20 0 -42 -22t-38 -63v-183q0 -50 12.5 -62t69.5 -16v-26h-230v26q47 5 58 17t11 61v207q0 49 -9 60.5t-53 16.5v23q74 12 141 40v-109z" /></g><g transform="matrix(.022,-0,0,-.022,23.196,18.513)"><path id="x69" d="M135 536q-20 0 -35 15.5t-15 35.5q0 22 15 37t36 15t35.5 -15t14.5 -37q0 -21 -15 -36t-36 -15zM252 0h-220v26q48 5 59 17t11 63v206q0 47 -9 58t-54 18v24q78 12 142 39v-345q0 -51 11.5 -63t59.5 -17v-26z" /></g><g transform="matrix(.022,-0,0,-.022,29.204,18.513)"><path id="x63" d="M390 111l17 -21q-34 -45 -80 -73.5t-89 -28.5q-91 0 -146 62t-55 147q0 118 101 195q74 57 149 57h1q59 0 90 -27q16 -14 16 -30q0 -15 -12 -29t-21 -14q-8 0 -19 11q-44 41 -101 41q-52 0 -87.5 -42.5t-35.5 -117.5q0 -49 15 -87t39 -58t49 -30t48 -10q33 0 60.5 12
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" /></g><g transform="matrix(.022,-0,0,-.022,91.229,18.513)"><path id="x79" d="M478 437v-26q-39 -6 -53 -17.5t-35 -54.5q-12 -24 -26.5 -59.5l-44 -107.5l-55.5 -134q-86 -205 -103 -270q-6 -25 -32 -25q-21 0 -38.5 15t-17.5 33q0 19 25 37q40 24 75 88q18 34 31 69q7 20 -2 45q-67 191 -114 306q-17 43 -31.5 56.5t-54.5 18.5v26h202l1 -26
q-35 -5 -42 -16t4 -39l90 -250q57 137 92 249q10 28 0 39.5t-52 16.5v26h181z" /></g><g transform="matrix(.022,-0,0,-.022,101.653,18.513)"><path id="x6C" d="M238 0h-223v26q48 5 60 17t12 61v473q0 50 -10.5 60.5t-58.5 15.5v24q73 8 148 35v-608q0 -49 11.5 -61t60.5 -17v-26z" /></g><g transform="matrix(.022,-0,0,-.022,107.324,18.513)"><path id="x29" d="M275 270q0 -296 -211 -440l-19 23q75 62 116.5 174t41.5 243t-42 243t-116 173l19 24q211 -144 211 -440z" /></g><g transform="matrix(.016,-0,0,-.016,115.1,7.75)"><path id="x2B" d="M535 230h-212v-233h-58v233h-213v50h213v210h58v-210h212v-50z" /></g></svg> EHIDA Analogue 

Bioinorganic Chemistry and Applications

Synthesis, Novel Crystal Structure, and -Amyloid Binding Property of Re(I) EHIDA Analogue

Figure 4