DNA Oxidative Cleavage Induced by the Novel Peptide Derivatives of 3-(quinoxalin-6-yl)alanine in Combination with Cu(II) or Fe(II) Ions

Figure 9

Result of the DNA treatment with the Fe(II) complexes of the studied compounds in the presence and absence of hydrogen peroxide. Lane 1, untreated DNA; lane 2, DNA treated with EcoRI endonuclease; lane 3, DNA + DFQa-Gly + H₂O₂; lane 4, DNA + Fe–DFQa-Gly; lane 5, DNA + Fe–DFQa-Gly + H₂O₂; lane 6, DNA + DPPZa-Gly + H₂O₂; lane 7, DNA + Fe–DPPZa-Gly; lane 8, DNA + Fe–DPPZa-Gly + H₂O₂; lane 9, DNA + DPQa-Gly + H₂O₂; lane 10, DNA + Fe–DPQa-Gly; lane 11, DNA + Fe–DPQa-Gly + H₂O₂; lane 12, DNA + Fe(II) + H₂O₂.