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Bioinorganic Chemistry and Applications
Volume 2009, Article ID 914105, 6 pages
Research Article

Synthesis, Characterization, Antibacterial and Anti-Inflammatory Activities of Enoxacin Metal Complexes

1Department of Chemistry, University of Karachi, Karachi-75270, Pakistan
2Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan
3PCMD, International Centre of Chemical Sciences, University of Karachi, Karachi-75270, Pakistan

Received 27 January 2009; Revised 25 March 2009; Accepted 4 May 2009

Academic Editor: Patrick Bednarski

Copyright © 2009 Saeed Arayne et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The present work comprises the synthesis of enoxacin (Heno) complexes with various transition metals. Two types of complexes and were obtained. The complexes were characterized by different physicochemical, spectroscopic, and elemental analysis. Results suggest that enoxacin interacts with the metals as a monoanionic bidentate ligand. These complexes were also tested for their antibacterial activity against eleven (11) different microorganisms, and the results were compared with the parent drug. Moreover all the metal complexes were also tested for their ability to scavenge reactive oxygen species where by and complexes exhibited potential to mediate anti-inflammatory response.