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Bioinorganic Chemistry and Applications
Volume 2009 (2009), Article ID 979680, 6 pages
Research Article

Synthesis, Spectroscopic and Thermal Characterization of Copper(II) and Iron(III) Complexes of Folic Acid and Their Absorption Efficiency in the Blood

1Department of Chemistry, Faculty of Science, Ain Shams University, Cairo, Egypt
2Department of Biochemistry, Genetic Engineering and Biotechnology Research Institute (GEBRI), Menoufia University, Sadat City, Egypt

Received 10 March 2009; Revised 27 April 2009; Accepted 5 June 2009

Academic Editor: Igor Fritsky

Copyright © 2009 E. Hamed et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The absorption efficiency of any drug in blood is of prime importance. Compounds having the general formula: , where ( or Fe(III), or 1 , , or 3 with respect), were prepared, and their absorption efficiency in rodent's blood was determined. The obtained compounds were characterized by elemental analysis, infrared as well as thermogravimetric analysis and polarization of light. The results suggest that the two folate complexes were formed in 1 : 2 molar ratio (metal : folic acid) which acted as a bidentate ligand through both carboxylic groups. Polarization of light proved that the folate complexes have symmetric geometry. Biological application proved that Cu(II) and Fe(III) complexes were absorbed more efficiently in rodent blood than folic acid itself.