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Bioinorganic Chemistry and Applications
Volume 2010, Article ID 168030, 10 pages
http://dx.doi.org/10.1155/2010/168030
Research Article

Synthesis, Structure, and Antiproliferative Activity of Three Gallium(III) Azole Complexes

1Department of Chemistry, University of Patras, 265 04 Patras, Greece
2Laboratory of Inorganic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis, 157 71 Zografou, Greece
3Institute of Materials Science, NCSR “Demokritos”, 153 10 Aghia Paraskevi Attikis, Greece
4“Theagenion” Cancer Hospital, Al. Simeonides str. 2, 540 07 Thessaloniki, Greece
5Department of Chemistry, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece
6The National Hellenic Research Foundation, 48, Vas. Constantinou Ave, 116 35 Athens, Greece

Received 25 March 2010; Accepted 1 May 2010

Academic Editor: Spyros Perlepes

Copyright © 2010 Stergios Zanias et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

As part of our interest into the bioinorganic chemistry of gallium, gallium(III) complexes of the azole ligands 2,1,3-benzothiadiazole (btd), 1,2,3-benzotriazole (btaH), and 1-methyl-4,5-diphenylimidazole (L) have been isolated. Reaction of btaH or btd with or resulted in the mononuclear complexes (1) and (2), respectively, while treatment of with L resulted in the anionic complex (3). All three complexes were characterized by single-crystal X-ray crystallography and IR spectroscopy, while their antiproliferative activities were investigated against a series of human and mouse cancer cell lines.